Conductive tissue engineering scaffold as well as preparation method and application thereof

A tissue engineering scaffold and conductive technology, applied in the field of biomedical materials, can solve the problems of low conductivity, poor mechanical properties and poor stability of conductive composite materials, and achieve high porosity, long-term electroactivity and good stability Effect

Inactive Publication Date: 2018-07-20
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned tissue engineering materials and methods have the problems of poor mechanical properties, poor stability and low conductivity of conductive composite materials.
[0008] Therefore, there is no ideal conductive tissue engineering scaffold in the prior art to meet the actual clinical needs

Method used

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  • Conductive tissue engineering scaffold as well as preparation method and application thereof
  • Conductive tissue engineering scaffold as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The selection and preparation method of embodiment 1 material

[0043] 1. Design of conductive fiber structure

[0044] 1. The preparation of the conductive fiber of the "shell-core" structure of the present invention

[0045] (1) Preparation of silkworm silk fibroin, desericin:

[0046] Weigh 50g of silkworm silk (including sericin), boil 2L of three-distilled water in an induction cooker, add 1g of anhydrous sodium carbonate after the water boils, put the weighed silkworm silk into the boiling water, and start timing when the water boils Keep the water boiling for 30 minutes, but pay attention to the overflow of boiling water, and stir it with a glass rod from time to time during the process. After the first pass of cooking, the silk is taken out of the water, washed in triple distilled water for 3-4 times, and then the above operation is repeated three times in total. After the last de-sericin removal, it is repeatedly eluted to neutrality with triple distilled wa...

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PUM

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Abstract

The invention discloses a conductive tissue engineering scaffold. The scaffold is made of a biocompatible material, conductive fiber or a network formed by the conductive fiber is arranged in the scaffold in an oriented manner, and the conductive fiber consists of a polypyrrole conductive casing and a silk fibroin core. The scaffold has good stability, excellent mechanical performance and lastingelectrical activity, oriented conductivity can be realized, electrical stimulation can promote growth and differentiation of cells, and the oriented fiber arrangement structure can perform oriented guide on nerve axon growth and promote nerve regeneration.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a conductive tissue engineering scaffold and its preparation method and application. Background technique [0002] Peripheral nerve injury is a common clinical problem that often leads to permanent disability. The typical symptoms of peripheral nerve injury are sensory and motor deficits, which may lead to complete paralysis or intractable neuropathic pain. Unlike nerves in the central nervous system, peripheral nerves can regenerate spontaneously to some extent. At present, autologous nerve transplantation is still the "gold standard", but the disadvantages of secondary surgery, limited availability, and size mismatch limit the widespread use of autologous nerve transplantation. Therefore, neural tissue engineering is a promising approach, and the preparation of a biological nerve conduit graft that can replace autologous nerve grafts is very valuable, but still...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/22A61L27/18A61L27/34D06M15/37C08G73/06D01D5/00D06M101/10
CPCA61L27/50A61L27/18A61L27/227A61L27/34A61L2430/32C08G73/0611D01D5/0015D06M15/37D06M2101/10C08L89/00C08L79/04
Inventor 杨宇民赵亚红李贵才顾晓松凌珏
Owner NANTONG UNIVERSITY
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