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Preparation and application of a kind of indole derivative

A technology of indole derivatives and extracts, applied in the field of microbial herbicides, can solve problems such as endangering human health, endangering the safety of agricultural products, environmental pollution and weed resistance, etc., and achieves low product cost, good herbicidal activity, and short cycle Effect

Active Publication Date: 2020-11-10
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for a long time, the application of chemical pesticides has caused a series of problems such as environmental pollution and increased weed resistance.
At the same time, excessive pesticide residues will also endanger the safety of agricultural products, and even endanger human health

Method used

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  • Preparation and application of a kind of indole derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Indole-like derivatives of chlamydosporin are shown in formula (1) (the Arabic numerals in the structure are the positions of carbon atoms),

[0023] .

Embodiment 2

[0024] Example 2: Fermentative production and separation and purification of chlamydosporin-like indole derivatives:

[0025] 1) Fermentation culture

[0026] Strain culture: According to the conventional culture method of microorganisms, pick a small amount of strains preserved in the agar-malt extract medium Fusarium chlamydosporum QJP1 was inoculated on the surface of a PDA plate, cultured at 28°C for 3 days, and was used as a strain for large-scale fermentation culture.

[0027] Cut off the appropriate amount of bacteria on the surface of the PDA plate, inoculate it into a sterilized Erlenmeyer flask filled with rice culture medium, and let it stand at room temperature for 30 days. Add ethyl acetate to sterilize and set aside.

[0028] The rice medium is 100 g / bottle of rice, 0.6 g / bottle of peptone, and 100 mL / bottle of artificial seawater.

[0029] 2) Separation and purification of compounds

[0030] The above-mentioned rice culture medium was ultrasonically extrac...

Embodiment 3

[0033] Embodiment 3: Herbicidal activity test

[0034] The agar mixed powder method established by Luo Xiaoyong et al. [Journal of Qingdao Agricultural University, 2007; 24(4): 267-270] is used for rapid determination of the herbicidal activity of compounds, which has high sensitivity, simple operation, short determination time and good repeatability , It can be widely screened with large throughput, and it is easy to observe the growth status of indicating plants. Luo Xiaoyong et al. used this method to quickly measure the herbicidal activity of 40 kinds of garden plant leaves. Zhang Lijuan [Plant Protection, 2016; 42:63-66.] and Su Fansheng [Applied Chemistry, 2014; 31:290-295.] used barnyardgrass as the test weed, and used the agar mixed powder method to quickly determine the corn stalk and herbicidal activity of imidazoles. Zhang Yun [Acta Microbiology, 2015; 55(3): 292-298.] and Li Shuai [Journal of Agricultural and Food Chemistry, 2014; 62(14): 8997-9001.] took Amarant...

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Abstract

The invention discloses preparation and application of a chlamydosporin type indole derivative. The derivative has a structure shown as a formula (I), has better herbicidal activity, has 95.8 percentof growth inhibition rate on [Echinochloa crusgalli (L.) Beauv.] radicles at a concentration of 5 mug / mL and also has 81.8 percent of growth inhibition rate on amaranthus retroflexus coleoptiles as aconcentration of 10 mug / mL. Therefore, the derivative can be taken as a leading compound with an herbicidal effect or a new pesticide ingredient. The derivative shown as the formula (I) is preserved in the China Microbial Culture Collection Management Center on December 9, 2016, with the preservation number of CGMCC No. 13198 and is prepared by fermentation, culture, extraction and separation, andthe chemical structure of the derivative is identified by nuclear magnetic resonance and mass spectrometry and other technologies.

Description

technical field [0001] The invention relates to a microbial herbicide, in particular to the preparation and application of a chlamydosporin-like indole derivative. Background technique [0002] Weeds have always been a major problem that plagues agricultural production, affects crop yields, or disrupts ecological balance. barnyard grass [ Echinochloa crusgalli (L.) Beauv .] is the most important weed in paddy fields and one of the 18 kinds of malignant weeds in the world. It is widely distributed and highly competitive. It mainly relies on herbicides for control in production. Amaranthus retroflexus ( Amaranthus retroflexus ) is a common weed in farmland, orchard, roadside and wasteland, and often pollutes crop seeds. If it is not effectively controlled, the yields of corn, soybeans, spring wheat, rapeseed and vegetables will be significantly damaged. [0003] In recent years, chemically synthesized pesticides have been widely used to control weeds in crops. But fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/18A01N43/38A01P13/00C12P17/10C12R1/77
CPCA01N43/38C07D209/18C12P17/10
Inventor 肖琳杜丰玉周远明王兆富
Owner QINGDAO AGRI UNIV
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