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Temperature-sensitive glucan-based hydrogel and preparation method thereof

A temperature-sensitive hydrogel and dextran technology, which is used in medical science, bandages, etc., can solve the problems of low porosity, poor mechanical properties, and poor air permeability of ordinary hydrogels, and achieve controllable drugs. Release, high mechanical properties, good biocompatibility

Active Publication Date: 2018-07-24
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, ordinary hydrogels have low porosity, poor gas permeability, low drug loading, and poor mechanical properties, and a biosafe way to improve the performance of existing hydrogels is urgently needed

Method used

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  • Temperature-sensitive glucan-based hydrogel and preparation method thereof
  • Temperature-sensitive glucan-based hydrogel and preparation method thereof
  • Temperature-sensitive glucan-based hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Preparation of porous thermosensitive dextran-based hydrogel

[0038] (1) Prepare an aqueous ammonium persulfate solution with a mass fraction of 5%, and then use 4.5ml of deionized water to prepare a solution containing 6.6% N-isopropylacrylamide and 0.33% N,N-methyleneacrylamide mixture. After the resulting mixed solution was mixed on a rotary oscillator, 135 μL of the configured ammonium persulfate aqueous solution was quickly added and quickly mixed on a rotary oscillator. The volume ratio of the added ammonium persulfate solution to the mixed solution was 3:100 .

[0039] (2) Add tetramethylethylenediamine to the solution obtained in step (1), and the volume ratio of tetraethylenediamine to the solution obtained in step (1) is 2:100. The obtained solution was quickly mixed on a rotary oscillator, quickly poured into a mold, and left to stand for 30 minutes to obtain a temperature-sensitive hydrogel.

[0040] (3) Take the formed hydrogel out of the mold...

Embodiment 2

[0042] Example 2 Preparation of porous thermosensitive dextran-based hydrogel

[0043] (1) Prepare an aqueous solution of ammonium persulfate with a mass fraction of 5%, and use 4.5ml of deionized water to prepare a mass fraction of 6.6% N-isopropylacrylamide, 0.33% N,N-methyleneacrylamide and 1 % NaHCO 3 mixed solution. After the resulting mixed solution was mixed on a rotary oscillator, 135 μL of the configured ammonium persulfate aqueous solution was quickly added and quickly mixed on a rotary oscillator. The volume ratio of the added ammonium persulfate solution to the mixed solution was 3:100 .

[0044] (2) Add tetramethylethylenediamine to the solution obtained in step (1), and the volume ratio of tetraethylenediamine to the solution obtained in step (1) is 2:100. The obtained solution was quickly mixed on a rotary oscillator, quickly poured into a mold, and left to stand for 30 minutes to obtain a temperature-sensitive hydrogel.

[0045] (3) Take the formed hydrogel...

Embodiment 3

[0047]Example 3 Preparation of porous thermosensitive dextran-based hydrogel

[0048] (1) Use 0.1ml of deionized water to prepare a potassium persulfate solution with a mass fraction of 3%, and use 10ml of deionized water to prepare a mixture containing 5% of carbityl acrylate and 0.1% of N-methylolacrylamide solution. After the resulting mixed solution was mixed on a rotary oscillator, the configured potassium persulfate solution was quickly added and quickly mixed on a rotary oscillator.

[0049] (2) Add tetramethylethylenediamine to the solution obtained in step (1), and the volume ratio of tetraethylenediamine to the solution obtained in step (1) is 0.8:100. The obtained solution was quickly mixed on a rotary oscillator, then quickly poured into a mold, and left to stand for 10 minutes to obtain a temperature-sensitive hydrogel.

[0050] (3) Take the formed hydrogel out of the mold, put it into a mixed solution containing 0.2%wt tannic acid, 1%wt dextran and 0.3%wt cipro...

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Abstract

The invention belongs to the technical field of medical functional dressing and in particular relates to temperature-sensitive glucan-based hydrogel and a preparation method thereof. The temperature-sensitive glucan-based hydrogel takes tannic acid as a crosslinking agent, and is double-network gel formed by temperature-sensitive hydrogel and glucan. The temperature-sensitive glucan-based hydrogelhas temperature-sensitive and antibacterial properties and can realize controllable release of drugs; the drug release is flexibly controlled along partial temperature changes of parts with inflammations; the hydrogel can be used for adsorbing wound percolate and has good biocompatibility and surface lubrication performance; secondary injuries to wounds are not easily caused in a clinical replacement manner; the hydrogel also has biodegradability and does not cause environment pollution.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to a temperature-sensitive dextran-based hydrogel and a preparation method thereof. Background technique [0002] Traditional wound dressings such as gauze, cotton wool, etc. are easy to stick to the wound site, and it is easy to cause secondary damage to the wound granulation tissue when the dressing is replaced or removed. Wound dressings should provide and maintain a moist environment around the wound, be able to exchange gases, and at the same time act as a barrier to foreign pollutants and microorganisms. Ideal wound dressing materials should be non-toxic, non-adhesive, not cause allergic reactions in the body, and have antibacterial properties, swelling and absorption properties, etc. [0003] Hydrogel is a polymer network system with a network cross-linked structure, soft in nature, capable of maintaining a certain shape, absorbing a large amount of water and hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L26/0085A61L2300/412A61L2300/41A61L2300/404A61L2300/402A61L2300/602C08L5/02C08L33/26
Inventor 方艳古蕾姜岷马江锋信丰学陈晓
Owner NANJING UNIV OF TECH
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