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PH sensitive corn protein-based compound membrane and preparation method thereof

A zein and sensitive technology, which is applied in the field of composite materials and drug carrier materials, can solve the problems of complex preparation process of drug composite membranes and lack of stimuli responsiveness

Inactive Publication Date: 2018-07-27
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of the above-mentioned drug composite membrane is relatively complicated, and it is not stimuli-responsive.

Method used

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  • PH sensitive corn protein-based compound membrane and preparation method thereof
  • PH sensitive corn protein-based compound membrane and preparation method thereof
  • PH sensitive corn protein-based compound membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 2 g of zein into a round bottom flask, add 12 mL of aqueous methanol (70% alcohol concentration), and stir at room temperature for 9 min to obtain a uniform zein dispersion. Weigh 0.2 g nano-SiO 2 , added to the zein dispersion, and ultrasonically dispersed for 6 minutes. After adding 0.8mL glycerin to it, raise the temperature to 60°C, and after magnetic stirring for 2 hours, apply the film-forming solution on the tinplate sheet, let it stand for cooling for 15 minutes, dry at 50°C for 1 hour, and peel off the film. The pH-sensitive zein-based composite membrane was obtained by storing in the medium for 18 h.

[0030] Take 0.5 g of dried zein-based composite film, dissolve it in 7 mL of 70% ethanol aqueous solution, add 1.5 mg of the drug molecule riboflavin, raise the temperature to 70 °C, stir for 2 h with magnetic force, and coat the film-forming solution separately. On the cleaned tinplate (12cm×5cm), let it stand for cooling for 10 minutes, bake in a const...

Embodiment 2

[0032] Weigh 2.5 g of zein into a round bottom flask, add 20 mL of 70% ethanol aqueous solution, and stir at room temperature for 15 min to obtain a uniform zein dispersion. Weigh 0.25g nano-SiO 2 , added to the above zein dispersion, and ultrasonically dispersed for 10 min. After adding 0.2 mL of glycerin and 0.7 g of polyethylene glycol to the reaction liquid, the temperature was raised to 65°C, and after magnetic stirring for 3 h, the film-forming liquid was coated on a tinplate sheet, left to cool for 20 min, and dried at a constant temperature of 65°C for 1.5 h, peeling off, and storing the film in a humidity-controlled box for 20 hours to obtain a pH-sensitive zein-based composite film.

[0033] Take 0.5 g of dried zein-based composite film, dissolve it in 7 mL of 70% ethanol aqueous solution, add 3 mg of the drug molecule riboflavin, raise the temperature to 70 °C, stir magnetically for 2 h, and coat the film-forming solution separately. On the cleaned tinplate (12cm×...

Embodiment 3

[0035] Weigh 3 g of zein into a round bottom flask, add 15 mL of ethanol aqueous solution, and stir at room temperature for 20 min to obtain a uniform zein dispersion. Weigh 0.4 g nano-SiO 2 , added to the above zein dispersion, and ultrasonically dispersed for 12 minutes. After adding 1.4 mL of glycerin to it, the temperature was raised to 70°C, and after magnetic stirring for 3.5 h, the film-forming solution was coated on a tinplate sheet, left to cool for 26 min, dried at a constant temperature of 60°C for 3 h, peeled off, and the film was placed in a humidity control box. Stored in medium for 28 hours, a pH-sensitive zein-based composite film was obtained.

[0036] Take 0.5 g of dried zein-based composite film, dissolve it in 7 mL of 70% ethanol aqueous solution, add 5 mg of the drug molecule riboflavin, raise the temperature to 70 °C, stir for 2 h with magnetic force, and coat the film-forming solution separately. On the cleaned tinplate (12cm×5cm), let it stand for cooli...

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Abstract

The invention discloses a pH sensitive corn protein-based compound membrane which is prepared by taking natural polymer corn protein as a base material, introducing in nano silicon dioxide and a biocompatible plasticizer and through simple mixing and hybridization and a solution casting method. The compound membrane has the good transparency, compactness and pH sensibility. The compound membrane is dissolved again and drug molecules are added, casting is conducted again, and a drug-carrying membrane is obtained; and the drug-carrying membrane has the pH sensibility, the accumulative release rate is greatly different under different pH conditions: rapid drug administration can be achieved under an alkalescent condition, and a slow-release effect is achieved under an acidic condition. Due tothe fact that the pH value of saliva of human is between 6.6 and 7.6, the compound membrane can be used as a carrier for curing skin injuries or dental ulcers.

Description

technical field [0001] The invention relates to a method for preparing protein film materials, in particular to the preparation of a pH-sensitive corn protein-based composite film; it has certain application prospects in the field of preparing drug-loaded films (such as oral ulcer films), and belongs to composite materials, The field of drug carrier materials. Background technique [0002] Film preparation is a thin-film dosage form made by dissolving or uniformly dispersing drugs in film-forming materials. It can be directly attached to the surface of skin wounds or oral ulcers, so that the drugs can directly contact the lesion and improve the utilization rate of the drugs. The commonly used film-forming materials mainly include biodegradable synthetic polymers and natural polymers, among which natural polymers are widely favored by people because of their renewability, good biocompatibility, safety, reliability, and biodegradability. For example: CN200610013183.6 disclose...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/42A61K47/52A61P1/02A61P17/02A61K31/525
CPCA61K9/006A61K9/7007A61K31/525A61K47/42A61K47/52A61P1/02A61P17/02
Inventor 何玉凤郭君慧王建凤王荣民杨艳
Owner NORTHWEST NORMAL UNIVERSITY
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