A method and system for analyzing metagenomic data

A data analysis system and metagenomics technology, which is applied in the field of metagenomics data analysis methods and systems, can solve the problems of many false positives, poor specificity, shortened analysis time, etc., and achieve the elimination of false positive results, reduced calculation, and control Calculate the effect of time
CN108334750BActive Publication Date: 2019-02-12SIMCERE DIAGNOSTICS CO LTD +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SIMCERE DIAGNOSTICS CO LTD
Publication Date
2019-02-12

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Abstract

The invention relates to a metagenomic data analysis method and system. The data analysis method and system of the present invention obtains the preliminary species identification result of the sample based on the k-mer algorithm, and based on the preliminary species identification result, extracts part or all of the supporting sequences, uses the blast algorithm to verify the preliminary species identification result, and judges Whether the preliminary species identification result is a reported detected species. The method and system of the present invention can reduce false positives, quickly and accurately obtain the reported species of the sample in a short period of time, and are compatible with a variety of mainstream sequencing platforms, and are suitable for second-generation sequencing technology and third-generation sequencing technology; The method and system of the present invention can also accurately identify and map the drug-resistant genes and drug-resistant mutation sites of samples to report detection species. Furthermore, the system of the present invention can be used to identify pathogenic microorganisms, especially endocarditis pathogens, and overcome the defect that they are difficult to cultivate.
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Description

technical field

[0001] The present invention relates to the field of bioinformatics, in particular to a metagenomic data analysis method and system. Background technique

[0002] Metagenome, also known as community genome, refers to the sum of the genetic material of all tiny organisms in a specific niche. Metagenomics (metagenomics) refers to the discipline that directly applies genomics technology to the study of microbial communities in niches without the need to isolate and cultivate a single strain.

[0003] Unlike previous microbiological analysis methods, metagenomics analysis does not need to screen the cultures of each microbial community, but directly determines the nucleic acid sequences of all microorganisms in the sample to analyze the growth of the microbial community. Metagenomics analysis can avoid the bias caused by changes in microbial sequences due to environmental changes, and is especially suitable for identifying microorganisms that are difficult to cu...

Claims

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