Novel affine thiophilic silicon ball chromatography material and preparation method and application thereof
A chromatographic material and affinity technology, applied in the field of chromatographic materials, can solve the problems of high production cost, low mechanical strength, and difficult storage, and achieve the effects of easy storage, strong mechanical properties, and simple steps
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preparation example Construction
[0021] The invention provides a preparation method of a novel affinity thiophilic silica sphere chromatographic material. The preparation method comprises: in the presence of a strong base, sulfamide, tris(2,3-epoxypropylene base) isocyanate (TEPIC) and amide silicon balls are copolymerized in the first organic solvent to obtain a copolymerized material
[0022] Through the above technical scheme, the novel affinity sulfurophilic silica sphere chromatographic material provided by the present invention has strong mechanical properties, is easy to store, has good dispersibility, and can have good specific enrichment and separation capabilities for compounds containing disulfide bonds, not only that , the preparation method of the present invention has simple steps, easy-to-obtain raw materials, and controllable reaction process, which is very favorable for popularization and application. The novel affinity sulfurophilic silica sphere chromatographic material of the present inv...
preparation example 1
[0052] The particle size range is 5μm, and the specific surface area range is 125-500m 2 / g silica porous silicon spheres were washed with NaOH (0.1mol / L), water, HCl (0.1mol / L), water and methanol in turn for 30min; the washed silicon spheres (5.0μm) were placed in an oven at 60 Dry for 12 hours; place the dried silicon spheres in a mixed solution of 3-aminopropyltrimethoxysilane and toluene (3-aminopropyltrimethoxysilane / toluene v / v 1:12) at 90°C Temperature, contact reaction 12h. After the reaction, the silicon spheres were rinsed with methanol, and oven-dried at 60° C. for 12 hours to obtain amide silicon spheres.
preparation example 2
[0054] Silicon amide spheres were prepared according to the method of Preparation Example 1, except that 3-aminopropyltrimethoxysilane / toluene v / v was 1:2.
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