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Preparation method of nitrochloroform capsule

A technology for chloropicrin and capsules, applied in the field of preparation of chloropicrin capsule dosage forms, can solve the problems of loss, unstable release of chloropicrin, etc., and achieves low production cost, saving application cost, significant environmental benefits and economical benefits effect of benefit

Active Publication Date: 2018-08-03
DALIAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention mainly solves the problem that a large amount of chloropicrin is lost during injection and application, and the release of chloropicrin is unstable and uncontrollable after being made into capsules

Method used

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  • Preparation method of nitrochloroform capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Accurately weigh and quantify sodium alginate and place it in a beaker, add distilled water and stir on a magnetic stirrer for 24 hours to fully dissolve to obtain a sodium alginate solution with a mass fraction of 1.5%, which is set aside. Add quantitative Tween-60 (mass ratio to sodium alginate solution: 1:100) to the sodium alginate solution, stir evenly, add quantitative chloropicrin to it according to the oil-water ratio of 1:3, use a high-speed emulsifying disperser Disperse at 4000r / min for 20min and mix evenly to make chloropicrin emulsion. Anhydrous calcium chloride and distilled water were used to prepare a calcium chloride solution with a mass concentration of 2% as a coagulation bath for subsequent use. Draw the prepared emulsion with a 100mL syringe and drop the emulsion into the calcium chloride solution through a needle tube under constant pressure. The process of granulation is always accompanied by stirring. After the granulation is completed, the caps...

Embodiment 2

[0015] Accurately weigh and quantify sodium alginate and gelatin (mass ratio: 3:1) into a beaker, add distilled water and stir on a magnetic stirrer for 24 hours to fully dissolve to obtain a sodium alginate composite wall material solution with a mass fraction of 2%, and set aside. Prepare a calcium lactate solution with a concentration of 2.0% as a coagulation bath for later use. Add a certain amount of Tween-60 to the sodium alginate solution (the mass ratio of the wall material solution is 1:100), stir evenly, add a certain amount of chloropicrin to it according to the oil-water ratio of 1:4, and use a high-speed emulsifying disperser 5000r / min high-speed emulsification to make chloropicrin emulsion. Draw the prepared emulsion with a 100mL syringe and drop the emulsion into the calcium lactate solution through the injection needle (30mL) under constant pressure, and stir at a low speed during the granulation process. After the granulation is finished, the spherical capsul...

Embodiment 3

[0017] The difference from Example 2 is that the concentration of the composite wall material is 1.5% (wherein the mass ratio of gelatin to sodium alginate is 1:3), the emulsifier is Tween 80, the emulsification speed is 4500r / min, and the emulsification time is 30min. Extrude with a 2mL needle tube, the concentration of calcium chloride in the coagulation bath is 2.0%, and the solidification time is 30min. The average particle diameter of the obtained capsules is 3mm.

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Abstract

The invention discloses a preparation method of a nitrochloroform capsule. The preparation method comprises the following steps: (1) taking sodium alginate solid or the sodium alginate solid and an auxiliary material to obtain a wall material water solution with the mass concentration of 0.5 to 3.5 percent, and standing for 24 hours for later use; (2) putting a core material nitrochloroform into the wall material water solution, adding a proper amount of emulgator tween 80 or tween 60, tween 20 and octenyl succinic acid modified starch, and performing high-speed emulsion dispersion for 30 to 60min to obtain emulsified liquid; (3) preparing the obtained emulsified liquid into the nitrochloroform capsule by adopting a piercing-solidifying method. The product is used for solving the existingproblem that in a process of applying nitrochloroform, the drug loss amount is great and the application environment is bad; in a process of applying the nitrochloroform capsule, peculiar smell is avoided, and a person applying the drug does not need special safeguard procedures, the production process of the capsule is simple and convenient, the production is low, the drug volatilization amount can be reduced by a capsule coating technology, the drug application cost is reduced, and remarkable environmental benefit and economic benefit are achieved.

Description

technical field [0001] The invention relates to a preparation method of a chloropicrin capsule dosage form. Background technique [0002] As a commonly used soil fumigant, chloropicrin (trichloropicrin) is widely used in strawberry, vegetables, ginger and other crops to control soil-borne diseases and insect pests, and its effect of inhibiting diseases and insect pests is remarkable. At present, the application method of chloropicrin is mainly to use manual injection of agents into the soil. Since chloropicrin is highly volatile and has a strong lacrimal effect, liquid injection application will cause part of the chloropicrin to be lost into the atmosphere. This will not only reduce the effectiveness of pesticides in controlling diseases and insect pests, but also make the pesticide application environment harsh, causing harm to the environment and human beings. In order to improve the application environment and reduce the loss of chloropicrin, the dosage forms of capsules...

Claims

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Application Information

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IPC IPC(8): A01N47/08A01N25/34A01N25/18A01P5/00A01P7/04A01P3/00
CPCA01N25/18A01N25/34A01N47/08
Inventor 谭凤芝曹亚峰刘兆丽李沅汪源浩陈永利刘晓东
Owner DALIAN POLYTECHNIC UNIVERSITY
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