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Antibacterial hydrophilic polyurethane foam medical dressing

A hydrophilic polyurethane and hydrophilic technology, which is applied in the field of medical and sanitary materials, can solve the problems of complex production process, poor safety of inorganic antibacterial agents, poor antibacterial durability, etc., to overcome complex process, low manufacturing cost, and small amount of addition Effect

Active Publication Date: 2018-08-03
INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to disclose a kind of antibacterial hydrophilic polyurethane foam medical dressing in order to overcome the existing complex manufacturing process of antibacterial polyurethane foam dressing, poor antibacterial persistence, and poor safety of inorganic antibacterial agents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Synthesis of Isocyanate Terminated Hydrophilic Prepolymer

[0014] Dry polyethylene glycol (PEG2000) in vacuum at 120°C for 24 hours, weigh 50g of dehydrated PEG2000, 3g of glycerin, 10g of TDI, stir under N2 protection, and react at 50°C until the NCO content is 8%. The end-capped hydrophilic prepolymer is denoted as A1.

[0015] Dry polyethylene glycol (PEG1000) in vacuum at 120°C for 24 hours to remove water, weigh 50g of dehydrated PEG1000, 3g of glycerol, 20g of TDI, stir under N2 protection, and react at 50°C until the NCO content is 7%. The end-capped hydrophilic prepolymer is denoted as A2.

[0016] Dry polyethylene glycol (PEG2000) in vacuum at 120°C for 24 hours to remove water, weigh 50g of dehydrated PEG2000, 3g of glycerol, 15g of TDI, stir under N2 protection, and react at 50°C until the NCO content is 10%. The end-capped hydrophilic prepolymer is denoted as A3.

[0017] Dry polyethylene glycol (PEG1000) in vacuum at 120°C for 24 hours to rem...

Embodiment 2

[0018] Example 2: Preparation of functional foaming mixture

[0019] Weigh 15g of surfactant L64, 5g of foam stabilizer L580, 0.5g of cationic polymer polyhexamethyleneguanidine hydrochloride (PHMG), add 80g of deionized water, stir and dissolve to form a colorless and transparent solution, and obtain functional foam bubble mixture B1;

[0020] Weigh 15g of surfactant F68, 5g of foam stabilizer L580, 0.8g of cationic polymer polyhexamethylene biguanide hydrochloride (PHMB), add 80g of deionized water, stir and dissolve to form a colorless transparent solution, and obtain a functional foam bubble mixture B2;

[0021] Weigh 20g of surfactant L64, 8g of foam stabilizer L580, 0.4g of cationic polymer polyhexamethyleneguanidine hydrochloride (PHMG), add 72g of deionized water, stir and dissolve to form a colorless and transparent solution, and obtain functional foam Soak mixture B3.

Embodiment 3

[0022] Embodiment 3: preparation of antibacterial hydrophilic polyurethane foam

[0023] Add the synthesized isocyanate-terminated hydrophilic prepolymer A1 into a high-speed disperser, stir at a speed of 4000rpm, then add a certain amount of functional foaming mixture B1, the mass ratio of A1 to B1 is 0.5:1, and continue to stir and disperse 10S, pour the dispersion mixture into a mold for foaming, and then mature the foamed material at 60°C for 2 hours to obtain an antibacterial hydrophilic polyurethane foam. The foam absorbs 15 times of its own weight. The antibacterial performance of the material was evaluated by direct contact method. After 7 days, the antibacterial rate of the material against Escherichia coli was 75%, that of Staphylococcus aureus was 83%, and that of Candida albicans was 80%.

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Abstract

An antibacterial hydrophilic polyurethane foam medical dressing is prepared by mixing a component A and a component B according to a mass ratio of 0.5-1 to 3-1 and foaming, wherein the component A isan isocyanate terminated hydrophilic prepolymer; the component B is a functional foaming mixture formed by mixing 1-10% of a surfactant, 0.9-10% of a foam stabilizer, 0.1-10% of a cationic polymeric antibacterial agent and 70-98% of water. The antibacterial hydrophilic polyurethane foam medical dressing has the characteristics of simple preparation technology and strong operability. The prepared antibacterial hydrophilic polyurethane foam medical dressing has a good antibacterial property, maintains the antibacterial property thereof for a long time, has a good hydrophilic liquid-absorbing property and is a novel functional medical wound dressing.

Description

technical field [0001] The invention relates to an antibacterial hydrophilic polyurethane foam medical dressing, which belongs to the technical field of medical sanitary materials. Background technique [0002] Medical wound dressing is an important biomedical material used to cover sores, wounds or other injuries. It can cover skin wounds to protect the wound, avoid secondary damage to the skin, and provide a favorable environment for wound healing. Its research and development has always been a hot issue. With the development of medical treatment technology and the needs of patients, people have higher requirements for the performance of dressings. Traditional cotton gauze dressings generally have many problems in the process of use, such as single product types and functions, no series of products, and functional defects. [0003] As a kind of functional dressing, polyurethane foam dressing is mainly suitable for wound care with a lot of exudate, such as leg ulcers, pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/42A61L15/44A61L15/46
CPCA61L15/26A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/206A61L2300/404C08L75/08
Inventor 孙复钱张鹏舒泉水
Owner INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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