Biodegradable compound type guided bone regeneration barrier membrane and preparation method thereof

Abstract

The invention belongs to the technical field of medical materials, and discloses a biodegradable compound type guided bone regeneration barrier membrane and a preparation method thereof. The biodegradable compound type guided bone regeneration barrier membrane comprises a biomedical magnesium rod and polylactic acid membranes pressed on the upper and lower faces of the magnesium rod. The method comprises the steps that the magnesium rod is clamped between two polylactic acid membranes, placed on a 180-DEG C hot pressboard, and conducted with hot pressing for 20 seconds. The biodegradable compound type guided bone regeneration barrier membrane and the preparation method thereof have the advantages that the novel bio-barrier membrane with good biocompatibility, capacity of selectively guiding the regeneration of tissues, certain mechanical strength, biodegradability, degradation rate coordinating with a process of bone tissue regeneration and other characteristics, the preparation technology is simple, and the cost is low.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a biodegradable composite guiding bone regeneration barrier film and a preparation method thereof. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: [0003] Guide Bone Regeneration (GBR) specifically refers to the use of barrier membranes to create a relatively closed space for bone tissue to heal, avoiding the entry of faster-growing epithelial cells or connective tissue in the bone defect area, which is conducive to promoting bone regeneration. Defect repair and regeneration, clinically used to rebuild periodontal support tissue, reduce tooth loss and promote long-term success rate of implant restoration, etc. To achieve guided bone regeneration, a barrier membrane must be used. [0004] The barrier membrane needs to meet: (1) selective filtration ability, only body fluid and nutrients nee...

AI Technical Summary

Problems solved by technology

[0008] (1) The strength of the existing degradable barrier film is small, and the space support ability is poor;

[0009] (2) The non-degradability of the existing non-degradable barrier membrane requires a second removal operation

[0010] (3) The complex preparation process and high cost of existing barrier membranes limit its clinical application

[0013] (1) The low tensile strength of the degradable barrier film leads to its poor mechanical strength, weak ability to maintain space, and frequent film collapse and displacement;

[0014] (2) The non-degradable barrier membrane cannot be absorbed by the body, and it is inevitable to be removed by secondary surgery, which will increase the pain of the patient

In clinical application, there are a large proportion of complications, such as mucosal dehiscence, membrane exposure, infection, etc., which directly lead to osteogenesis failure;

[0015] (3) The preparation process of the existing barrier film is complicated and the cost is high

Images