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Sponge material as well as preparation method and application thereof

A sponge and cross-linking reaction technology, applied in medical science, bandages, etc., can solve problems such as difficulty in maintaining the cross-linking reaction of polyvinyl alcohol and chitosan, difficulty in reflecting the treatment effect of the affected area, and hindering the smooth progress of the foaming process. Excellent therapeutic effect, high water absorption, high porosity effect

Active Publication Date: 2018-08-10
BEIJING YINGJIA MEDICAL MATERIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In related technologies, polyvinyl alcohol solution and chitosan solution are mostly used for homogeneous crosslinking reaction, but in this case, chitosan can only be added in a very low amount, and the addition of a large amount of chitosan will significantly Increasing the viscosity of the reaction system hinders the smooth progress of the foaming process. At the same time, increasing the proportion of chitosan also makes it difficult to maintain the crosslinking reaction between polyvinyl alcohol and chitosan in a homogeneous system.
Adopt the method of related technology, if increase the consumption of chitosan, will cause a large amount of chitosan not to participate in the cross-linking reaction, the product after curing is in actual use, the chitosan that does not participate in the cross-linking reaction will be Very easy to fall off directly or block the foaming channel
Under the situation that the dosage of chitosan is limited in the related art, the obtained product is difficult to reflect the therapeutic effect to the affected part again

Method used

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  • Sponge material as well as preparation method and application thereof
  • Sponge material as well as preparation method and application thereof

Examples

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preparation example Construction

[0047] The specific embodiment of the present invention provides a method for preparing a sponge material, including:

[0048] A catalyst and a crosslinking agent are added to the polyvinyl alcohol solution, stirred for crosslinking reaction and foaming, chitosan solid is added, and stirring is continued for crosslinking reaction and foaming, and a sponge material is obtained by curing.

[0049] Both polyvinyl alcohol and chitosan have hydroxyl groups in their molecular chains, and both have the ability to undergo condensation reactions with crosslinking agents. When solid powdered chitosan is added to the polyvinyl alcohol foaming system, it will also dissolve on the surface of its particles, and the local microscopic dissolution will undergo a homogeneous crosslinking reaction with the crosslinking agent, making polyvinyl alcohol and chitosan macroscopically Hybrid foaming becomes possible.

[0050] Chitosan powder is added during the foaming process of polyvinyl alcohol. When the...

Embodiment 1

[0097] A method for preparing sponge material includes:

[0098] a. Dissolve polyvinyl alcohol (polymerization degree 400; alcoholysis degree 88%) in water at 70° C. and a stirring speed of 200 rpm to prepare an aqueous solution of polyvinyl alcohol with a mass concentration of 10%;

[0099] b. Add dilute H to the polyvinyl alcohol aqueous solution 2 SO 4 Aqueous solution (mass fraction of 36%, H 2 SO 4 The dosage is 7% of the total mass of polyvinyl alcohol solution and chitosan solids) and formaldehyde (the dosage is 60% of the total mass of polyvinyl alcohol solution and chitosan solids), at 65°C and 1000rpm stirring speed. Cross-linking reaction and foaming for 60 minutes;

[0100] c. Add chitosan (molecular weight 10 2 ; Deacetylation degree is 50%) solid (particle size is 80 mesh, the mass ratio of polyvinyl alcohol and chitosan solid is 1:0.1), at 65 ℃, 1000rpm stirring speed, continue to stir for cross-linking reaction and hair Soak for 60min;

[0101] d. Pour the reaction so...

Embodiment 2

[0103] A method for preparing sponge material includes:

[0104] a. Dissolve polyvinyl alcohol (polymerization degree of 2600; alcoholysis degree of 99%) in water at 95° C. and a stirring speed of 50 rpm to prepare a polyvinyl alcohol aqueous solution with a mass concentration of 40%;

[0105] b. Add dilute H to the polyvinyl alcohol aqueous solution 2 SO 4 Aqueous solution (mass fraction of 36%, H 2 SO 4 The dosage is 3% of the total mass of polyvinyl alcohol solution and chitosan solids) and formaldehyde (the dosage is 20% of the total mass of polyvinyl alcohol solution and chitosan solids), at 20°C and 200 rpm stirring speed. Cross-linking reaction and foaming for 20 minutes;

[0106] c. Add chitosan (molecular weight 10 6 ; Deacetylation degree is 95%) solid (particle size is 140 mesh, the mass ratio of polyvinyl alcohol and chitosan solid is 1:0.4), at 20 ℃, 200 rpm stirring speed, continue to stir for cross-linking reaction and hair Soak for 20min;

[0107] d. Pour the reaction...

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Abstract

The invention provides a sponge material as well as a preparation method and application thereof. The preparation method of the sponge material has a simple process; the specific addition reaction sequence is used; after the polyvinyl alcohol crosslinking to a certain degree, chitosan solids are added for further reaction; the consumption proportion of the chitosan can be obviously improved; the chitosan can sufficiently take part in the crosslinking reaction; the condition of excessive chitosan falling in the obtained sponge material cannot be caused; the comprehensive performance such as porosity, water absorption rate, moisture preservation rate and ventilation rate of the obtained sponge material can be sufficiently ensured; meanwhile, the obtained sponge material can achieve an excellent treatment effect on the affected part. The sponge material has high chitosan content ratio, high porosity, high water absorption rate, high moisture preservation rate, high ventilation rate and excellent comprehensive performance. The sponge material can be used as medical dressing; the excellent treatment effect can be achieved on the affected part.

Description

Technical field [0001] The invention relates to the technical field of polymer foaming materials, in particular to a sponge material and a preparation method and application thereof. Background technique [0002] In recent years, many materials and treatment methods have been invented for the treatment of trauma. Among them, the negative pressure sealing drainage treatment technology has been widely recognized and used. The core material of this treatment method is polyvinyl alcohol foam (PVA FOAM, PVF or polyvinyl alcohol foam) with good strength, elasticity, softness and biocompatibility. Under negative pressure, it exerts even pressure on the wound surface to stop bleeding. The negative pressure causes the secretions of the wound surface to be drained into the collection bottle through the open pore structure of the sponge, thereby playing the role of cleaning the wound surface. This treatment method reduces the frequency of dressing changes, accelerates wound healing, and r...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L5/08C08J9/08A61L26/00
CPCA61L26/0014A61L26/0023A61L26/0066A61L26/0085A61L2300/232A61L2300/412C08J9/08C08J2203/02C08J2329/04C08J2405/08C08L5/08C08L29/04
Inventor 朱铁桥
Owner BEIJING YINGJIA MEDICAL MATERIAL CO LTD