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Quzhou fructus aurantii, Quzhou fructus aurantii extract and application of medicine composition containing Quzhou fructus aurantii or Quzhou fructus aurantii extract to maintenance of functions of islet cells

A technology of islet cells and compositions, which is applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of patients with poor curative effect, islet cell function damage, and poor curative effect, and achieve the protection of islet cells , strong pharmacological effect, and low production cost

Active Publication Date: 2018-08-17
衢州市人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the drugs that can promote insulin secretion are sulfonylureas and glinides, but these drugs have a variety of adverse reactions, such as hypoglycemia, gastrointestinal reactions, cardiovascular risks, etc. Sabotaging patients with poor outcomes
[0004] At present, there have been literature reports and patent applications on the use of mature Changshan Huyou peel extract as a medicinal substance to treat diabetes and hyperlipidemia, but the curative effect is not good

Method used

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  • Quzhou fructus aurantii, Quzhou fructus aurantii extract and application of medicine composition containing Quzhou fructus aurantii or Quzhou fructus aurantii extract to maintenance of functions of islet cells
  • Quzhou fructus aurantii, Quzhou fructus aurantii extract and application of medicine composition containing Quzhou fructus aurantii or Quzhou fructus aurantii extract to maintenance of functions of islet cells

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Embodiment approach

[0022] According to a preferred embodiment of the present invention, the extract of Fructus Aurantii Fructus is the alcohol extract of Fructus Aurantii Fructus that is prepared by heating and reflux extraction, and the extraction method includes:

[0023] (1) After the decoction pieces of Fructus Aurantii Fructus are pulverized, reflux extraction is carried out with an alcohol solvent to obtain an extract;

[0024] (2) separating the solid and liquid of the extract, and reclaiming the alcohol solvent to obtain a concentrated solution;

[0025] (3) drying the concentrated solution to obtain the extract of Fructus Fructus Quercis.

[0026] According to the present invention, in step (1), the particle size of the pulverized product of Fructus aurantii Fructus can be selected within a wide range.

[0027] Wherein, the amount of the alcohol solvent can be selected within a wide range, preferably, relative to each kilogram of Fructus Fructus Fructus Fructus, the amount of the alcoh...

preparation example 1

[0054] This preparation example is used to illustrate the preparation of Quci Fructus Alcohol Extract

[0055] Weigh 1 kg of Fructus Aurantii medicinal material, crush it, add 15 times the amount of 80% ethanol (15000 mL), soak for 1 h, heat and reflux for extraction 3 times, each time for 2 h, combine the extracts, cool and filter, recover the solvent from the filtrate, and dry. That is, the alcohol extract of Fructus Fructus Fructus Citrus Fructus (A1).

preparation example 2

[0057] This preparation example is used to illustrate the preparation of Fructus Aurantii Fructus Water Extract

[0058] Weigh 1kg of the medicinal material of Fructus Aurantii, crush it, add 15 times the amount of water, soak for 1 hour, heat and reflux for extraction 3 times, 2 hours each time, combine the extracts, cool and filter, concentrate and dry to obtain the Fructus Aurantii water extract object (A2).

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Abstract

The invention relates to the field of treatment of functions of islet cells and particularly relates to Quzhou fructus aurantii, a Quzhou fructus aurantii extract and application of a medicine composition containing Quzhou fructus aurantii or Quzhou fructus aurantii extract to protection of islet cells, recovery of the functions of the islet cells, acceleration of insulin secretion or increase ofthe number of the islet cells. The invention creatively develops new medicinal application of Quzhou fructus aurantii and also develops a new application field. The Quzhou fructus aurantii has the effects of protecting the islet cells, accelerating the insulin secretion, recovering the depleted islet cells and increasing the number of the islet cells, has strong pharmacological effects, and is safe and non-toxic; the product is safe, is rich and cheap in raw material resources, free of toxic and side effects, simple in preparation process route, low in production cost and convenient to use, can be prepared into the conventional preparations such as oral preparations and tablets and the like, and is used as an islet cell protection agent which is extremely promising and has good developmentvalue.

Description

technical field [0001] The present invention relates to the field of pancreatic islet cell function therapy, in particular to the preparation of islet cell protection, recovery of islet cell function, promotion of Use in drugs that secrete insulin or increase the number of islet cells. Background technique [0002] Diabetes Mellitus (DM) is a chronic endocrine and metabolic disease caused by genetic and environmental factors and characterized by elevated blood sugar levels, mainly including insulin-dependent type 1 diabetes (Type1Diabetes Mellitus, T1DM), non- Insulin-dependent type 2 diabetes (Type2DiabetesMellitus, T2DM) and gestational diabetes (Gestational Diabetes Mellitus, GDM) three types. Among them, the incidence of T2DM accounts for more than 90% of the diabetic population. The study found that although insulin resistance is considered to be the most important factor in the process of T2DM, in contrast, the damage of islet cell function can aggravate the process ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A61P5/50A61P3/10
CPCA61K36/752A61P3/10A61P5/50
Inventor 楼丽君张峰王思为
Owner 衢州市人民医院
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