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Application of sanshool in preparation of external preparation for repairing skin photodamage

A kind of sanshool and the technology of its use, which are applied in the field of preparation of external preparations for repairing skin photodamage by sanshool

Active Publication Date: 2020-05-08
四川昇嘉科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no report that sanshool is used to repair skin photodamage

Method used

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  • Application of sanshool in preparation of external preparation for repairing skin photodamage
  • Application of sanshool in preparation of external preparation for repairing skin photodamage
  • Application of sanshool in preparation of external preparation for repairing skin photodamage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1, the preparation of the Chinese prickly ash extract containing sanshool

[0019] Take 2 kg of dried Zanthoxylum bungeanum peel and crush it, use 16 kg of ethanol solution with a volume fraction of 85% to cold extract the Zanthoxylum bungeanum peel powder for 48 hours, extract 3 times, combine the extracts, discard the drug residues, and concentrate the extracts under reduced pressure Obtain concentrated solution, the volume of concentrated solution is 1 / 5~1 / 4 of leaching liquid, obtains the hydroxyl sanshool mixture; Dilute the obtained hydroxyl sanshool mixture with water to ethanol solution volume fraction and be 20%, pass HP-20 type Macroporous adsorption resin column chromatography was used for separation and purification. The weight ratio of dried Zanthoxylum bungeanum fruit to the volume of macroporous adsorption resin was 1Kg: 0.7L, and the sample was dynamically adsorbed. The adsorption speed was controlled at 2.5BV per hour. After the adsorption was...

Embodiment 2

[0021] A cosmetic for repairing skin photodamage, which is composed of the following raw materials in the following weight ratio: 73% deionized water, 8% 1,3-propanediol, 3.5% pentylene glycol, cyclopentasiloxane 3%, polydimethylsiloxane 3%, pepper extract containing sanshool 2%, maltooligosaccharide glucoside 2%, triglyceride 2%, pentaerythritol tetraester 2%, caprylyl glycol / glycerin / poly Acrylic Copolymer 1.5%.

[0022] Preparation method: Mix and stir deionized water, 1,3-propanediol, pentanediol and maltooligosaccharide glucoside in the formula and heat to 85-90°C; add cyclopentasiloxane, dimethicone Methyl siloxane, triglyceride, pentaerythritol tetraester and caprylyl glycol / glycerin / polyacrylic acid copolymer continue heating and stirring, and after cooling to room temperature, add the pepper extract containing sanshool in the formula and stir and mix evenly.

[0023] How to use: Take an appropriate amount and apply it to the skin directly, once a day, without washing...

Embodiment 3

[0025] A cosmetic for repairing skin photodamage, which is composed of raw materials in the following weight ratio: 74% deionized water, 8% 1,3-propanediol, 3.5% pentylene glycol, cyclopentasiloxane 3%, polydimethylsiloxane 3%, pepper extract containing sanshool 1%, maltooligosaccharide glucoside 2%, triglyceride 2%, pentaerythritol tetraester 2%, caprylyl glycol / glycerin / poly Acrylic Copolymer 1.5%.

[0026] Preparation method: Mix and stir deionized water, 1,3-propanediol, pentanediol and maltooligosaccharide glucoside in the formula and heat to 85-90°C; add cyclopentasiloxane, dimethicone Methyl siloxane, triglyceride, pentaerythritol tetraester and caprylyl glycol / glycerin / polyacrylic acid copolymer continue heating and stirring, and after cooling to room temperature, add the pepper extract containing sanshool in the formula and stir and mix evenly.

[0027] How to use: Take an appropriate amount and apply it to the skin directly, once a day, without washing, and apply mo...

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PUM

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Abstract

The invention provides applications of sanshool, or an isomer of sanshool, or an extracted product containing sanshool in preparation of drugs or cosmetics used for preventing and / or treating skin light injuries. It is shown by experiment results that sanshool is capable of increasing the propagation activity of fibroblasts, inhibiting expression of MMP-1 and MMP-3, reducing extracellular matrix degradation, and relieving skin light injury symptoms obviously, can be used in preparation of drugs or cosmetics used for preventing and / or treating skin light injuries, and is promising in market application prospect.

Description

technical field [0001] The invention relates to the use of sanshool in preparing an external preparation for repairing skin photodamage. Background technique [0002] Ultraviolet radiation, especially medium-wave ultraviolet (UVB) can cause a series of damage to the skin, and induce a series of acute and chronic reactions such as erythema, blisters, inflammation, roughness, thickening, pigmentation, telangiectasia, and photoaging of the skin. The thickness of the epidermis of photodamaged skin varies, accompanied by focal atrophy or hyperplasia, and different degrees of melanosis. In the dermis, the arrangement of elastic fibers is disordered, the hyperplasia of mucopolysaccharides and the proliferative ability of fibroblasts are weakened. Photodamaged skin diseases are a type of skin diseases caused directly or indirectly by sunlight, especially ultraviolet radiation, mainly including: ①photoaging; ②photosensitive skin diseases, such as: polymorphous light eruption (polymo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/16A61K36/758A61P17/16A61K8/42A61K8/9789A61Q19/00
CPCA61K8/42A61K8/9789A61K31/16A61K36/758A61K2800/782A61P17/16A61Q19/004
Inventor 蒋献柯博文郝丹
Owner 四川昇嘉科技有限公司