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Chemical immunization luminometer probe cleaning fluid and preparation method thereof

An immunoluminescence and cleaning solution technology, applied in the field of immunological instruments, can solve problems such as affecting test results, sample residues, patient or hospital damage, etc., and achieve the effects of convenient process control, simple preparation process, and long-term storage.

Inactive Publication Date: 2018-09-14
SUZHOU YOUJUN ENVIRONMENTAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the instrument is used for continuous sample addition, it is unavoidable that the instrument probe will cause some samples to remain on the probe due to continuous sampling and sample addition, especially after detecting high-concentration samples and then testing low-concentration samples. Cause low-concentration sample test results to deviate, thereby affecting the test results and causing damage to patients or hospitals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A chemical immunoluminescence instrument probe cleaning solution, which is composed of the following components in proportion by weight: 45 parts of triethanolamine, 25 parts of dipotassium hydrogen phosphate, 30 parts of potassium citrate, 12 parts of sodium chloride, zinc sulfate 15 parts, 21 parts of calcium chloride, 15 parts of polyethylene glycol, 10 parts of sodium lauryl sulfonate, 6 parts of polyoxyethylene lauryl ether, 8 parts of nitrilotriacetic acid, 0.7 parts of Tween-80, ampicillin 0.7 parts of penicillin, 0.3 parts of sodium azide, and 160 parts of deionized water.

[0018] A preparation method of a chemiluminescence instrument probe cleaning solution, comprising the following steps:

[0019] Step 1. Heat deionized water to 41°C, slowly add polyethylene glycol, sodium lauryl sulfonate, lauryl polyoxyethylene ether, and nitrilotriacetic acid in sequence, stir and dissolve at a stirring speed of 60rpm, and wait until After the reagent was completely disso...

Embodiment 2

[0024] A chemical immunoluminescence instrument probe cleaning solution, which is composed of the following components in proportion by weight: 39 parts of triethanolamine, 21 parts of dipotassium hydrogen phosphate, 28 parts of potassium citrate, 13 parts of sodium chloride, zinc sulfate 14 parts, 17 parts of calcium chloride, 10 parts of polyethylene glycol, 9 parts of sodium lauryl sulfonate, 5 parts of polyoxyethylene lauryl ether, 7 parts of nitrilotriacetic acid, 0.7 parts of Tween-80, ampicillin 0.5 parts of penicillin, 0.2 parts of sodium azide, and 140 parts of deionized water.

[0025] A preparation method of a chemiluminescence instrument probe cleaning solution, comprising the following steps:

[0026] Step 1. Heat deionized water to 39°C, slowly add polyethylene glycol, sodium lauryl sulfonate, lauryl polyoxyethylene ether, and nitrilotriacetic acid in sequence, stir and dissolve at a stirring speed of 70rpm, and wait until After the reagent was completely dissol...

Embodiment 3

[0031] A chemical immunoluminescence instrument probe cleaning solution, which is composed of the following components in proportion by weight: 39 parts of triethanolamine, 28 parts of dipotassium hydrogen phosphate, 31 parts of potassium citrate, 15 parts of sodium chloride, zinc sulfate 15 parts, calcium chloride 19 parts, polyethylene glycol 9 parts, sodium lauryl sulfonate 10 parts, lauryl polyoxyethylene ether 5 parts, nitrilotriacetic acid 6 parts, Tween-80 0.6 parts, ampicillin 0.5 parts of penicillin, 0.3 parts of sodium azide, and 120 parts of deionized water.

[0032] A preparation method of a chemiluminescence instrument probe cleaning solution, comprising the following steps:

[0033] Step 1: Heat deionized water to 40°C, slowly add polyethylene glycol, sodium lauryl sulfonate, lauryl polyoxyethylene ether, nitrilotriacetic acid in sequence, stir and dissolve at a stirring speed of 70rpm, wait until After the reagent was completely dissolved, it was placed at 21°C...

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PUM

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Abstract

The invention discloses chemical immunization luminometer probe cleaning fluid and a preparation method thereof. The chemical immunization luminometer probe cleaning fluid is prepared from the following components in parts by weight: 33-55 parts of triethanolamine, 19-35 parts of dipotassium phosphate, 21-40 parts of potassium citrate, 9-19 parts of sodium chloride, 11-20 parts of zinc sulfate, 11-28 parts of calcium chloride, 3-19 parts of polyethylene glycol, 6-15 parts of sodium dodecyl sulfate, 3-9 parts of polyoxyethylene lauryl ether, 2-12 parts of nitrilotriacetic acid, 0.5-1 part of tween-80, 0.2-1 part of ampicillin, 0.1-0.4 part of sodium azide and 100-200 parts of deionized water. By synergistic effect of the various components, the prepared chemical immunization luminometer probe cleaning fluid is simple in preparation process, easy to product and suitable for being stored for a long time, and process control is facilitated; and the cleaning fluid can clean probe residues within a short time, and the detecting result is not affected.

Description

technical field [0001] The invention relates to the technical field of immunological instruments, in particular to a cleaning solution for a chemical immunoluminescent instrument probe and a preparation method thereof. Background technique [0002] Immunoassay is widely used in clinical diagnosis, environmental monitoring, forensic diagnosis and other technical fields due to its fast detection speed, high sensitivity and good specificity. Immunoassay was first applied to radioimmunoassay, but it was greatly restricted due to its disadvantages such as environmental pollution and potential harm to personnel; furthermore, the promotion of enzyme immunoassay technology has been widely used. The process is complicated, prone to human error, and takes too long. In addition, its detection sensitivity and enzyme storage have always been the reasons that hinder its further development. Recently, the advent of the automatic chemiluminescence instrument has solved the above problems w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D1/83C11D3/37C11D3/33C11D3/30C11D3/28C11D3/20C11D3/06C11D3/04C11D3/60
Inventor 凌云凌天阳金可心夏戊君
Owner SUZHOU YOUJUN ENVIRONMENTAL SCI & TECH