Sustained-release tablet for promoting oral cavity and/or esophageal mucosa repair and preparation method thereof

Abstract

The present invention relates to a sustained-release tablet for promoting oral cavity and / or esophageal mucosa repair. The tablet includes a tablet base including edible gum, maltose or mannitol, xylitol, sorbitol, a flavouring agent and a plasticizer with the weight ratio of the edible gum, the maltose or mannitol, the xylitol, the sorbitol, the flavoring agent and the plasticizer being 20-30%: 15-25%: 20-30%: 15-25%: 3-5% : 5-10%; and functional component factors distributed in the tablet base and including a recombinant human granulocyte macrophage stimulating factor. The problem in the treatment of oral cavity and / or esophageal mucositis produced by chemotherapy is solved. The invention also relates to a preparation method of the sustained-release tablet, and the method is simple to operate.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a slow-release tablet for promoting mucosal repair and a preparation method thereof. Background technique [0002] Radiation therapy is one of the main treatment methods for head, neck and thoracic malignant tumors, especially in the treatment of nasopharyngeal carcinoma, lung cancer, esophageal cancer and other tumors, the role of radiotherapy is irreplaceable. While radiation therapy kills tumor cells, it will inevitably cause damage to normal tissues around the tumor tissue and along the path of the rays. The most common damage is to the mucosa, including the oral cavity, oropharynx, and esophagus. Depending on the degree of injury, it may manifest as simple localized inflammation, mucosal shedding to form ulcers, severe cases may be complicated by deep mucosal bacterial or fungal infection, perforation of the soft palate or hard palate in the oral cavity, and perforation of the esopha...

AI Technical Summary

Problems solved by technology

Intravenous administration, inconvenient to use, and obvious systemic reactions, including excessive blood, abnormal blood viscosity, low blood pressure, headache, nausea or vomiting, etc.

Therefore, the patient's compliance is reduced to a certain extent, which is not conducive to preventive and therapeutic use.

The deficiency of the gargle administration method is mainly that the gargle exists for a short time, and in order to maintain the concentration of the medicine in the gargle, the amount of the gargle is usually used in a large amount, and the economic benefit is poor.