Drug releasing method based on 4D printing shape memory polymer structure

A memory polymer and drug release technology, which is applied in the direction of making drugs into special physical or taking forms of devices, additive processing, etc., can solve the problems of low repeatability, high production cost, complex pharmaceutical process, etc. Strong repeatability, low preparation cost, overcoming the effect of complex pharmaceutical process

Active Publication Date: 2018-09-21
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of complex pharmaceutical process, high production cost and low repeatability in the existing sustained and controlled release drugs, and to provide a drug release method based on 4D printing shape memory polymer structure

Method used

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  • Drug releasing method based on 4D printing shape memory polymer structure
  • Drug releasing method based on 4D printing shape memory polymer structure
  • Drug releasing method based on 4D printing shape memory polymer structure

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specific Embodiment approach 1

[0025] Specific Embodiment 1: In this embodiment, a drug release method based on a 4D printed shape memory polymer structure is as follows: 1. Mix the shape memory polymer with the drug at room temperature to obtain a drug-loaded shape memory polymer; 2. The drug-loaded shape memory polymer is prepared by 4D printing technology to prepare the drug release structure of the initial configuration; 3. Heating the drug release structure of the initial configuration to the glass transition temperature, and then changing the drug release structure of the initial configuration into a temporary The drug release structure of the configuration, and then down to room temperature, the drug release structure of the temporary configuration is obtained; wherein the surface area of ​​the drug release structure of the temporary configuration is smaller than the drug release structure of the initial configuration; four, release the drug release structure of the temporary configuration In an envir...

specific Embodiment approach 2

[0031] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the mass percentage of the drug in the drug-loaded shape memory polymer in Step 1 is 0.5-15%. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0032] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the shape memory polymer is polylactic acid, polyvinyl alcohol, polyurethane, polycaprolactone, chitosan, cross-linked polyethylene, One or more of polynorbornene, trans polyisoprene or styrene-butadiene copolymer are combined in any ratio. Others are the same as in the first or second embodiment.

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Abstract

The invention relates to a drug releasing method based on a 4D printing shape memory polymer structure. The invention aims at solving the problems that according to an existing sustained-release drug,the drug preparation technology is complex, preparation cost is higher, and repeatability is lower. Shape memory polymers and a drug are mixed at the indoor temperature, a shape memory polymer carrying the drug is obtained, an initial constructed drug releasing structure is prepared through a 4D printing technology, the structure is heated to the glass transition temperature, the initial constructed drug releasing structure is converted to a temporary constructed drug releasing structure with a smaller superficial area, the temporary constructed drug releasing structure is placed in the environment which is prepared for simulating human body fluid, external motivators are given, the initial constructed drug releasing structure is recovered, and the whole process is completed. According tothe method, the preparation cost is low, the method is simple, and it is due to the fact that 4D printing process parameters are consistent, the repeatability is high. The method is applied to the field of intelligent drug releasing.

Description

technical field [0001] The invention relates to a drug release method based on a 4D printed shape memory polymer structure. Background technique [0002] The new drug delivery system has always been a hot research direction in the field of pharmacy, especially in the field of anti-tumor pharmacy, but its research progress is still slow, due to the limitations of traditional pharmaceutical technology, drug excipients and drug dosage forms, Traditional drug dosage forms still have many problems in terms of drug release, drug side effects, etc. For example, traditional drug dosage forms cannot precisely control the amount of drug release, nor can they control drug release at a precise time, and many anti-tumor drugs The toxicity to normal cells is still very large, and it cannot improve the efficacy of drugs and other issues. Traditional drug dosage forms often fail to exert the efficacy and function of drugs well, while better sustained-release drug dosage forms often have pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00
CPCA61J3/00B33Y10/00B33Y70/00B33Y80/00
Inventor 冷劲松张风华李春妍刘彦菊
Owner HARBIN INST OF TECH
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