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A Molecularly Imprinted Polymer with Controlled and Sustained Release Function

A technology of molecular imprinting and polymer, applied in the direction of active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, pharmaceutical formulations, etc. People's satisfaction and other issues, to achieve the effect of drug sustained release

Active Publication Date: 2018-04-06
BEIJING PURKINJE GENERAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the drug release rate of molecularly imprinted materials reported in the literature is not much different from that of non-imprinted materials, and the results are not satisfactory. Most of the molecularly imprinted materials are biocompatible with acrylic acid and acrylamide as functional monomers. and poor degradability

Method used

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  • A Molecularly Imprinted Polymer with Controlled and Sustained Release Function
  • A Molecularly Imprinted Polymer with Controlled and Sustained Release Function

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preparation example Construction

[0031] Preferably, the molecularly imprinted polymer as described above, the preparation method of the β-cyclodextrin modified methacrylic acid comprises:

[0032] 1), dissolving methacrylic acid and toluene diisocyanate in an aprotic polar solvent, and polymerizing under the catalysis of dibutyltin dilaurate;

[0033] 2) The aprotic polar solvent is added to the product obtained in step 1), and β-cyclodextrin is added for reaction, and the reaction product is obtained after washing, recrystallization and drying.

[0034] Preferably, in the above molecularly imprinted polymer, the molar ratio of methacrylic acid, toluene diisocyanate and β-cyclodextrin is (0.4-0.6):(0.8-1.2):(0.4-0.6).

[0035] More preferably, the toluene diisocyanate (TDI) is toluene-2,4-diisocyanate.

[0036] Methacrylic acid (MAA) and TDI were polymerized to form the backbone of molecularly imprinted polymer functional monomers.

[0037] Preferably, for the molecularly imprinted polymer as described abov...

Embodiment 1

[0052] (1) Synthesis of functionalized functional monomers:

[0053] Synthesized according to the stoichiometric ratio of 0.4M MAA:1.2M TDI:0.4Mβ-CD. Mix toluene-2,4-diisocyanate (TDI, 2.284mL, 0.4M), methacrylic acid (MAA, 1.018mL, 1.2M) and dissolve in 20mL dimethylacetamide (DMAC), stir, add 0.1% ( 0.02mL) of dibutyltin dilaurate (DBTDL) as catalyst. Nitrogen was blown for 10 min, and magnetic stirring was performed at room temperature for 1 h. The MAA-TDI system was analyzed by UV to confirm the reaction. Then β-cyclodextrin (β-CD, 0.4M, 454 mg) was added, supplemented with 5 mL of dimethylacetamide. Nitrogen blowing, stirring for 2h (TLC tracking reaction, developer: petroleum ether / ethyl acetate, 2 / 1 ~ 3 / 1, v / v). The obtained product MAA-β-CD was washed three times with ultrapure water, and recrystallized with methanol to obtain a white solid, which was vacuum-dried to constant weight.

[0054] (2) Preparation of atropine molecularly imprinted polymer by thermally i...

Embodiment 2

[0057] (1) Synthesis of functionalized functional monomers:

[0058] Synthesized according to the stoichiometric ratio of 0.6M MAA:0.8M TDI:0.6Mβ-CD. Mix toluene-2,4-diisocyanate (TDI, 3.426mL, 0.6M), methacrylic acid (MAA, 0.678mL, 0.8M) and dissolve in 20mL dimethylacetamide (DMAC), stir, add 0.1% ( 0.02mL) of dibutyltin dilaurate (DBTDL) as catalyst. Nitrogen was blown for 10 min, and magnetic stirring was performed at room temperature for 1 h. The MAA-TDI system was analyzed by UV to confirm the reaction. Then β-cyclodextrin (β-CD, 0.6M, 680 mg) was added, supplemented with 5 mL of dimethylacetamide. Nitrogen blowing, stirring for 2h (TLC tracking reaction, developer: petroleum ether / ethyl acetate, 2 / 1 ~ 3 / 1, v / v). The obtained product MAA-β-CD was washed 4 times with ultrapure water, and then recrystallized with methanol to obtain a white solid, which was dried in vacuo until constant weight.

[0059] (2) Preparation of atropine molecularly imprinted polymer by therm...

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Abstract

The invention relates to the field of sustained-release technologies for medicines, in particular to a molecularly imprinted polymer with a controllable sustained-release function. The molecularly imprinted polymer has the advantages that methacrylic acid modified by beta-cyclodextrin is used as a functional monomer, atropine sulfate is used as a template molecule, class specific characteristics of molecularly imprinted polymers are combined with a sustained-release function of the beta-cyclodextrin, and accordingly the molecularly imprinted polymer with the controllable sustained-release function has long-acting medicine release time; the molecularly imprinted polymer with the controllable sustained-release function is customized for medicine template molecules and accordingly is high in selectivity for the released medicine template molecules.

Description

technical field [0001] The present invention relates to the technical field of drug sustained release, in particular to a molecularly imprinted polymer with controllable sustained release function. Background technique [0002] Molecularly imprinted polymers (MIP) is a specific molecular recognition material designed and prepared artificially. Its high-efficiency recognition has a good selective enrichment effect on target molecules in complex sample matrices. Molecularly imprinted polymers have been widely used in the fields of purification, catalysis, and antibody simulation, but the research and application of sustained-release drug loading is still a relatively new field. [0003] There are two main advantages of using MIP in the drug sustained-release system: First, because there are multiple interaction sites and matching cavities between the drug template molecule and MIP, the adsorption capacity of MIP to the drug template molecule is higher than that of the traditio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/34C08F222/14C08J9/28C08J9/26A61K47/69A61K31/46
CPCA61K31/46C08F220/34C08F220/343C08J9/26C08J9/28C08J2333/14C08F222/14
Inventor 佘永新
Owner BEIJING PURKINJE GENERAL INSTR
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