A kind of preparation method of nitrofurantoin enteric-coated tablet
A technology for nitrofurantoin and enteric-coated tablets, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problem of high content of excipients, low bioavailability, and improve the production of nitrofurantoin enteric-coated tablets. Cost and other problems, to overcome the excessive content of excipients, reduce production costs, and improve the effect of bioavailability
Active Publication Date: 2020-09-01
JIANGSU SIHUAN BIOENGINEERING PHARM CO LTD
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AI Technical Summary
Problems solved by technology
The applicant noticed that this prior art has the defect of excessive content of excipients and low bioavailability, thus increasing the production cost of nitrofurantoin enteric-coated tablets
Method used
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Experimental program
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Embodiment Construction
[0025] The present invention will be described in detail below in conjunction with various embodiments, but it should be noted that these embodiments are not limitations of the present invention, and those of ordinary skill in the art can make functional, method, or structural equivalent transformations or replacements based on these embodiments. , all fall within the protection scope of the present invention.
[0026] A preparation method of nitrofurantoin enteric-coated tablets, comprising the following steps:
[0027] Step S1, sieve the nitrofurantoin, starch, lubricant, and sodium carboxymethyl starch with an 80-mesh sieve, put them into a wet granulator and dry mix for 10-15 minutes, add 10% starch slurry, and stir to granulate.
[0028] Step S2, place the prepared granules in a boiling dryer, boil and dry at 70°C-80°C for 30-40 minutes, sieve the dried granules, and add lubricant, sodium carboxymethyl starch, Silica, total mix 10 minutes.
[0029] Step S3, spraying the...
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The invention provides a method for preparing macrodantin enteric-coated tablets. The method comprises the following steps: screening macrodantin, starch, a lubricant and sodium carboxymethyl starch by using 80-mesh screening sieve, carrying out dry mixing for 10-15 minutes in a wet-method pelletizing machine, adding 10% starch slurry, and carrying out stirring pelletizing; carrying out boiling drying on obtained granules for 30-40 minutes at 70-80 DEG C in a boiling dryer, screening the dried granules, shaping granules, and mixing with the lubricant, the sodium carboxymethyl starch and silicon dioxide for 10 minutes in all; carrying out wet-method pelletization in a wet-method mixing pelletizing method so as to obtain wet granules; drying the wet granules, carrying out tabletting so as toobtain core balls; coating the surfaces of the core balls with a gelatin layer, an enteric-coated layer, a sub-coat layer and a sugar coating layer in sequence from inside to outside. By adopting themethod for preparing the macrodantin enteric-coated tablet, auxiliary materials for preparing the tablets are remarkably reduced, the defect that a conventional macrodantin enteric-coated tablet hastoo many auxiliary materials can be overcome, the bioavailability can be improved, and the production cost of the macrodantin enteric-coated tablets can be lowered.
Description
technical field [0001] The invention relates to the technical field of pharmacy, in particular to a preparation method of nitrofurantoin enteric-coated tablets. Background technique [0002] Nitrofurantoin is an excellent antibacterial drug with a broad antibacterial spectrum. After oral administration, it is rapidly and completely absorbed and excreted quickly. The excretion in urine can reach 40-50%. It is often used to treat urinary tract infections caused by various sensitive bacteria. . It has effects on Gram-negative and positive bacteria, and is mainly used for urinary tract infections caused by sensitive bacteria, especially for acute urinary tract infections caused by Escherichia coli and Proteus. It is clinically used for urinary system infection caused by sensitive bacteria, such as pyelonephritis, urinary tract infection, cystitis and prostatitis, etc. [0003] Northern Pharmacy 2006, Volume 3, Issue 4 provides research on the formulation and process of nitrofu...
Claims
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IPC IPC(8): A61K9/40A61K9/32A61K9/36A61K47/36A61K31/4178A61P31/04
CPCA61K9/2059A61K9/2826A61K9/2853A61K9/2873A61K9/2886A61K31/4178A61P31/04
Inventor 丁月萍沈振宇宋紫薇江永红
Owner JIANGSU SIHUAN BIOENGINEERING PHARM CO LTD