Anti-Ebola virus monoclonal antibody, its preparation method and use

A monoclonal antibody, Ebola virus technology, applied in the fields of immunology and molecular biology, to achieve high ADCC activity, good antigen binding activity and virus neutralization activity, and good clinical application prospects.
CN108570106BActive Publication Date: 2021-07-16BEIJING MABWORKS BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING MABWORKS BIOTECH
Publication Date
2021-07-16

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Abstract

The invention belongs to the fields of immunology and molecular biology, and relates to an anti-Ebola virus monoclonal antibody, its preparation method and application. Specifically, when it comes to anti-Ebola virus monoclonal antibodies or antigen-binding parts thereof, the amino acid sequences of the light chain and heavy chain variable regions are selected from a group of (1)-(3) as follows: (1 ) The amino acid sequence of the light chain variable region is shown in SEQ ID NO: 4, the amino acid sequence of the heavy chain variable region is shown in SEQ ID NO: 6; (2) the amino acid sequence of the light chain variable region is shown in SEQ ID NO As shown in: 10, the amino acid sequence of the heavy chain variable region is shown in SEQ ID NO: 12; (3) the amino acid sequence of the light chain variable region is shown in SEQ ID NO: 16, the amino acid sequence of the heavy chain variable region As shown in SEQ ID NO:18. The anti-Ebola virus monoclonal antibody of the invention has enhanced ADCC activity, good antigen binding activity and virus neutralization activity.
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Description

Technical field

[0001] The present invention belongs to the field of immunology, molecular biology, involving a monoclonal antibody against an Ebola virus, and methods and applications thereof. Background technique

[0002] Ebola Virus is translated as an Ibola virus. It is a very rare virus. In 1976, it was discovered in the southern part of Sudan and the Ebola River in the southern Congolese (Golden) (Old Werald). Wide attention and attention, "Ebola" is here. Ebola virus is a strong infectious disease virus that can cause Ebola bleeding in human and primate, biosafety grade is 4 (AIDS is 3, SARS is Level 3, and the larger level is more Strictly); Ebola virus is mainly transmitted through paths of blood, saliva, sweat and secretions, and the virus incubation period can reach 2 to 21 days, but usually only 5 days to 10 days; the patients with viral infections mortality at 50 % To 90%; the cause of death is mainly stroke, myocardial infarction, low blood volume shock or multiple ...

Claims

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