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Preparation method of self-repairing medical catheter coating

A medical catheter, self-healing technology, applied in the direction of catheter, coating, etc., can solve the problems of reducing the service life of medical catheter, limiting the scope of use of medical catheter, etc., and achieves the effect of simple operation, short time and good antibacterial performance.

Inactive Publication Date: 2018-09-28
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During use, it will be affected by a certain degree of external environment, such as mechanical wear, body fluid impact, strong acid and strong alkali corrosion, etc. These effects will limit the scope of use of medical catheters, reduce the service life of medical catheters and affect their use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] The preparation of self-repairing medical catheter coating comprises the following steps:

[0027] Step 1. Apply the positively charged chitosan (CS) solution dropwise on the medical catheter material; then immerse it in the negatively charged dialdehyde starch (DS) solution for a period of time, then take out the medical catheter and use distilled water Rinse several times; repeat the above process several times to obtain the self-repairing medical catheter coating, wherein the soaking time is 2-10 minutes.

Embodiment 1

[0029] The 10mg / mL chitosan (CS) solution was drip-coated on the medical catheter material; then the medical catheter was immersed in the 1 mg / mL dialdehyde starch (DS) solution for 5 minutes, and then the medical catheter was taken out and rinsed with distilled water for 5 minutes. times; repeat the above process 10 times to obtain the self-repairing medical catheter coating,

Embodiment 2

[0031] The 20mg / mL chitosan (CS) solution was drip-coated on the medical catheter material; then the medical catheter was immersed in the 2 mg / mL dialdehyde starch (DS) solution for 5 minutes, and then the medical catheter was taken out and rinsed with distilled water for 5 minutes. times; repeat the above process 5 times to obtain the self-repairing medical catheter coating.

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Abstract

The invention discloses a preparation method of a self-repairing medical catheter coating. A chitosan (CS) solution with positive charge is first applied to a medical catheter material by dripping, and then the medical catheter material is soaked into a dialdehyde starch (DS) solution with negative charge for a period of time, then a medical catheter is removed and rinsed with distilled water repeatedly, and chitosan and dialdehyde starch are assembled on the medical catheter repeatedly. As the reversible schiff base connection can be formed between an amino group of the chitosan and an aldehyde group of the dialdehyde starch, and the schiff base substance formed has good biological properties, the medical catheter coating prepared in a layer-by-layer self-assembly method has self-repairing properties and antibacterial effects. The preparation method is simple, effective and easy to operate and requires less time.

Description

technical field [0001] The invention relates to a preparation technology of a self-repairing medical catheter coating, belonging to the technical field of medical catheters. Background technique [0002] Medical catheter is a basic medical device product, which is a general term for lumen products that connect the inside and outside of the human body. There are different material products such as polyethylene terephthalate, fluororesin, stainless steel, superelastic alloy, polyvinyl chloride, polyurethane, etc., in diagnosis, drainage, treatment, drug administration, monitoring, gas delivery, blood transmission and rehabilitation is widely used. At this stage, China's medical and health system is relatively mature, and the aging situation is becoming more and more obvious. The demand for medical catheters is steadily increasing. [0003] The service life of medical catheters ranges from 24 hours to 90 days. During use, it will be affected by a certain degree of external e...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14A61L29/16
CPCA61L29/085A61L29/14A61L29/16A61L2300/232A61L2300/404A61L2420/06C08L5/08C08L3/10
Inventor 葛丽芹任姣雨宣红云
Owner SOUTHEAST UNIV
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