A use of Pistacia weinmannifolia for skin whitening and wrinkle improvement

A fragrance wood, wrinkle technology, applied in the field of skin external preparation composition, health functional food, skin whitening or wrinkle improvement cosmetic composition, it can solve the problems of unexpectable effect, small effect, limited usage, etc., and reach the skin Excellent whitening effect and wrinkle improvement effect

Active Publication Date: 2018-10-09
KOREA RES INST OF BIOSCI & BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when applied to the skin, there are problems in that the amount of use is limited due to safety issues such as irritation and redness, or the actual effect cannot be expected due to the small effect
However, except for such reports, nothing is known about the skin-whitening and wrinkle-improving activities of the extracts, isolates thereof, or compounds isolated therefrom.

Method used

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  • A use of Pistacia weinmannifolia for skin whitening and wrinkle improvement
  • A use of Pistacia weinmannifolia for skin whitening and wrinkle improvement
  • A use of Pistacia weinmannifolia for skin whitening and wrinkle improvement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Example 1: Cosmetic raw material screening of 14 kinds of plants and the activity of fenugreek

[0095] In order to select cosmetic raw materials, experiments were carried out on the anti-inflammatory, anti-oxidation, whitening, skin protection effects and wrinkle improvement effects of 14 kinds of plant extracts.

[0096] 1-1.14 Anti-inflammatory effects of plant extracts

[0097] 1-1-1. Determination of flavonoid content

[0098] It is known that flavonoids have antibacterial, anticancer, antiviral and anti-inflammatory activities, and play an antioxidant role in living organisms. In order to measure the amount of flavonoids, the absorbance of yellow flavan or water-soluble flavonol glycoside produced by treating the sample with alkali was measured. According to the standard curve, the total content of flavonoids in 14 kinds of plant extract samples was calculated.

[0099] As a result, the total flavonoid contents in 14 kinds of plant extracts were as follows f...

Embodiment 2

[0132] Embodiment 2: Fragrant wood shoot extract, isolate and compound manufacture

[0133] The anti-inflammation, anti-oxidation, whitening and wrinkle-improving effects of fenugreek, which showed remarkable effects among the 14 kinds of plants confirmed in Example 1 above, will be described more specifically.

[0134] 2-1. Manufacture of the extract of the aerial parts of fenugreek

[0135] Methanol extract of Pistacia weinmannifolia J.Poiss.Ex Franch was purchased from the Overseas Plant Extract Bank of the Overseas Biomaterials Herbal Medicine Center of the Korea Institute of Biotechnology.

[0136] The extraction process is as follows: collect 20kg of leaves of the fragrant wood, use a drier (50 to 55) to carry out natural drying (drying in the shade), remove water and then pulverize, based on the dry weight of the pulverized powder sample, after adding 30L of methanol , extracted at normal temperature, after that, after filtering and concentrating under reduced pressu...

Embodiment 3

[0149] Example 3: Confirmation of activity of fenugreek extract and isolate

[0150] 3-1. Anti-inflammatory activity of fenugreek extracts and isolates

[0151] 3-1-1. Cytotoxicity determination of fenugreek samples

[0152] In order to measure the cytotoxicity of the fenugreek sample, the macrophage RAW264.7 cells of the mouse were added to the DMEM (Dulbecco's Modified Eagle Medium, Gibco company) medium with 5% fetal bovine serum (Fetal Bovine Serum) as 1×10 5 / ml concentration suspension, inoculated on 96-well plate (96well plate) with the amount of 100 μl each time, make it adhere. After 4 hours, the fenugreek sample was treated to a concentration of 20 μg / ml. After culturing for 24 hours, add 10 μl of 5 mg / ml MTT solution to each well, and after further culturing for 4 hours, remove the supernatant, add 100 μl of DMSO each time, measure the absorbance at 570 nm, and treat the negative cells treated with DMSO 0.25%. The control group was set at 100% and the cell via...

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Abstract

The present invention relates to the use of Pistacia weinmannifolia for skin whitening and wrinkle improvement. The present invention also relates to a cosmetic composition comprising an extract of Pistacia weinmannifolia or an isolate thereof as an active ingredient. The composition comprises the extract of Pistacia weinmannifolia or an isolate thereof as an active ingredient and exhibiting tyrosine associated with melanin synthesis, enzyme activity inhibition, melanin production inhibition in melanocytes, cytoprotection against ultraviolet rays, inhibition of expression of MMP-1 and MMP-3 aswrinkle-related genes, promotion of expression of elastin genes, etc. Therefore, the Pistacia weinmannifolia is excellent in skin whitening effect and wrinkle improvement effect.

Description

technical field [0001] The present invention relates to a cosmetic composition comprising an extract or an isolate of Pistacia weinmannifolia as an active ingredient, and more specifically, to a skin whitening or wrinkle-improving composition comprising an extract or an isolate of Pistacia weinmannifolia as an active ingredient. Cosmetic composition, skin external preparation composition and health functional food. Background technique [0002] With the development of science and the extension of human life expectancy, attention to functional cosmetics is also increasing. Human skin is the first defense tissue and the largest immune organ that protects the body from various harmful environments. In order to protect it, it is required to develop functional cosmetics with effects such as whitening, UV protection, and wrinkle improvement. [0003] Human skin color is determined genetically by the concentration and distribution of melanin in the skin, but it is also affected by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/02A61Q19/08A23L33/105
CPCA61Q19/02A61Q19/08A23L33/105A61K8/9789A23V2002/00A61K2800/782A23V2200/318A23V2200/302
Inventor 吴世湸安境燮金泰荣李晚谊文柱明金航金斗英柳亨杬李尚雨崔常镐权玉京金正姬
Owner KOREA RES INST OF BIOSCI & BIOTECH
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