Photosensitive micro-needle, preparation method for same and controlled release method implemented by aid of photosensitive micro-needle

A micro-needle, photosensitive technology, applied in pharmaceutical formulations, medical preparations with inactive ingredients, metabolic diseases, etc., can solve the problems of short half-life, physical, mental and economic pressure of patients, long-term and frequent insulin injection, etc. Simple, easy to prepare in large batches, controlled release effect

Inactive Publication Date: 2018-10-09
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many deficiencies in this method of administration: for example, insulin has a short half-life in the blood (3 to 5 minutes), and only a small part of it can enter the liver to play a hypoglycemic effect through human blood circulation; long-term and frequent injections of insulin are required, thus Cause multiple physical, mental and economic pressures on patients
In recent years, the microneedle drug delivery system has made great progress, but there are still many challenges to realize its clinical application, such as: rapid and sensitive response release of drugs in microneedles; biocompatibility of microneedle materials, etc.

Method used

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  • Photosensitive micro-needle, preparation method for same and controlled release method implemented by aid of photosensitive micro-needle
  • Photosensitive micro-needle, preparation method for same and controlled release method implemented by aid of photosensitive micro-needle
  • Photosensitive micro-needle, preparation method for same and controlled release method implemented by aid of photosensitive micro-needle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Mix the liquid polydimethylsiloxane prepolymer (PDMS) and the curing agent at a mass ratio of 10:1, pour it on the PMMA microneedle male mold, then vacuumize to remove air bubbles, and then place it at normal pressure at 80°C Heating under ambient conditions for 6 hours, and finally demoulding to obtain a PDMS microneedle negative mold.

[0033] Get 0.5g polyvinylpyrrolidone (PVP) mixed with 0.1g calcium carbonate (CaCO 3 ), 0.3g metformin hydrochloride (Met) and 0.4g (0.044wt%) photothermal factor bismuth nano-quantum dots (Bi) were dissolved in 1mL deionized water and stirred evenly to obtain a needle mixture of drug-loaded microneedles. Wherein, the particle size of bismuth nano quantum dots is less than 10nm.

[0034] In addition, pure PVP hydrogel with a mass fraction of 40wt% needs to be configured as the microneedle matrix material.

[0035] Pipette 6 mg of the needle mixture of the drug-loaded microneedles and pour it into the cavity of the PDMS template, and ...

Embodiment 2

[0044] The preparation of the microneedle template is the same as in Example 1.

[0045] Get 0.6g polyvinylpyrrolidone (PVP) mixed with 0.05g calcium carbonate (CaCO 3 ), 0.3g metformin (Met) and 0.2g (0.022wt%) photothermal factor bismuth quantum dots (Bi) were dissolved in 1mL deionized water and stirred evenly to obtain a needle mixture of drug-loaded microneedles.

[0046] In addition, pure PVP hydrogel with a mass fraction of 30wt% needs to be configured as the microneedle matrix material.

[0047] Pipette 8 mg of the needle mixture of the drug-loaded microneedles and pour it into the cavity of the PDMS template, and then centrifuge at 8000 rpm for 10 min. Then pipette 30wt% PVP hydrogel and pour it into the cavity of the template again until it is completely filled, then centrifuge at 6000rpm for 10min, take out the whole mold and place it at room temperature to air dry naturally, and finally demould to obtain uncoated photosensitive microneedles Bi-Met / CaCO 3 / PVP.

...

Embodiment 3

[0050] The preparation of the microneedle template is the same as in Example 1.

[0051] Take 0.7g polyvinyl alcohol (PVA) mixed with 0.1g calcium carbonate (CaCO 3 ), 0.2g metformin and 0.8g (0.089wt%) photothermal factor bismuth quantum dots (Bi) were dissolved in 1mL deionized water and stirred evenly to obtain a needle mixture of drug-loaded microneedles.

[0052] In addition, pure PVA hydrogel with a mass fraction of 20 wt% needs to be configured as the microneedle matrix material.

[0053] Pipette 10 mg of the needle mixture of the drug-loaded microneedles and pour it into the cavity of the PDMS template, and then centrifuge at 8000 rpm for 8 min. Then pipette 20wt% PVA hydrogel and pour it into the inner cavity of the template again until it is completely filled, then centrifuge at 8000rpm for 10min, take out the whole mold and place it at room temperature to air dry naturally, and finally demould to obtain uncoated photosensitive microneedles Bi-Met / CaCO3 / PVP.

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Abstract

The invention belongs to the technical field of micro-needle transdermal medicine administration, and particularly relates to a photosensitive micro-needle, a preparation method for the same and a controlled release method implemented by the aid of the photosensitive micro-needle. The photosensitive micro-needle comprises a matrix and a plurality of needles. The needles are attached to the matrixand comprise main materials, medicine factors and photo-thermal conversion factors, and the main materials are mixed with the medicine factors and the photo-thermal conversion factors and are solidified; phase transformation materials with low melting points are coated on the needles. The photosensitive micro-needle, the preparation method and the controlled release method have the advantages thatthe phase transformation materials with the low melting points are used as surface coatings of the needles, near-infrared light can be absorbed by the photo-thermal conversion factors in the needlesand can be transformed into heat, accordingly, the coatings on the surfaces of the needles can be melted, body fluid can be absorbed by the needles and can be gradually dissolved or degraded, and themedicine factors embedded in the needles can be released.

Description

technical field [0001] The invention belongs to the technical field of microneedle transdermal drug delivery, and in particular relates to a photosensitive microneedle, a preparation method thereof, and a controllable release method. Background technique [0002] "Diabetes" is a chronic disease in which glucose in the blood tends to accumulate too much, and is clinically characterized by "hyperglycemia". The control of blood sugar accompanies diabetic patients throughout their life. Insufficient insulin secretion or insulin resistance leads to relative or absolute lack of insulin. Subcutaneous or intravenous injection of insulin is currently the most direct and effective way to control blood sugar levels in diabetic patients. However, there are many deficiencies in this method of administration: for example, insulin has a short half-life in the blood (3 to 5 minutes), and only a small part of it can enter the liver to play a hypoglycemic effect through human blood circulatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/12A61K47/34A61K47/32A61K47/02A61K47/36A61K31/155A61P3/10
CPCA61K9/0021A61K31/155A61K47/02A61K47/12A61K47/32A61K47/34A61K47/36A61P3/10
Inventor 江国华张洋刘德朋童再再杨玉慧马翩翩
Owner ZHEJIANG SCI-TECH UNIV
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