Noble metal nanoparticles modified by small drug molecules, preparation method and application thereof

A nanoparticle and small molecule technology, applied in the field of nanomaterials, can solve the problems of cumbersome post-processing of products, cumbersome reactions, etc., and achieve the effect of inhibiting the aggregation of amyloid protein, single particle size distribution, and good application prospects

Active Publication Date: 2021-01-05
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the preparation of precious metal nanoparticles modified by small drug molecules usually adopts the method of chemical synthesis, which has disadvantages such as cumbersome reactions, the need to add surfactants, and the resulting products require cumbersome post-processing.

Method used

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  • Noble metal nanoparticles modified by small drug molecules, preparation method and application thereof
  • Noble metal nanoparticles modified by small drug molecules, preparation method and application thereof
  • Noble metal nanoparticles modified by small drug molecules, preparation method and application thereof

Examples

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Embodiment 1

[0042] The embodiment of the present invention provides a kind of noble metal nanoparticles modified by small drug molecules. The specific preparation method is as follows: the noble metal target is placed in a 7 mL, 100 μg / mL aqueous solution of epigallocatechin gallate, and the focal length of the laser is 17.5 cm, ablate the gold target for 10 minutes under the energy of 100mJ, use 1500rpm magnetic stirring to assist to obtain a uniform solution, and dialyze the obtained solution for 48h.

[0043] figure 1 It is a TEM image of the epigallocatechin gallate-modified gold nanoparticles prepared in Example 1 of the present invention.

[0044] From figure 1 It can be seen from the results in that the prepared gold nanoparticles modified with epigallocatechin gallate have a single particle size distribution and good dispersion, and the particle size is about 2.78±0.51nm.

[0045] In addition, the ultraviolet-visible absorption spectrum of the noble metal nanoparticles modified ...

Embodiment 2

[0053] Example 2 of the present invention provides a noble metal nanoparticle modified with small drug molecules. Compared with Example 1, the only difference is that the noble metal target used is silver, and the laser energy is 50mJ.

[0054] image 3 TEM image of the silver nanoparticles modified with epigallocatechin gallate prepared in Example 2 of the present invention. It can be seen from the figure that the size distribution of the obtained nanoparticles is relatively uniform, about 9.24±2.91 nm, which is larger than that of the gold nanoparticles modified with epigallocatechin gallate.

[0055] The UV-absorption spectrum and infrared spectrum of the product obtained in Example 2 of the present invention were evaluated in the same manner as in Example 1 of the present invention. It can be seen from the results that epigallocatechin gallate was modified on the silver nanoparticles.

Embodiment 3

[0057] Example 3 of the present invention provides a noble metal nanoparticle modified with small drug molecules. Compared with Example 1, the only difference is that the noble metal target used is platinum.

[0058] Figure 4 TEM image of platinum nanoparticles modified with epigallocatechin gallate prepared in Example 3 of the present invention. It can be seen from the figure that the size distribution of the obtained nanoparticles is relatively uniform, about 1.69±0.42nm, which is smaller than that of the gold nanoparticles modified with epigallocatechin gallate.

[0059] The UV-absorption spectrum and infrared spectrum of the product obtained in Example 3 of the present invention were evaluated in the same manner as in Example 1 of the present invention. From the results, it can be known that epigallocatechin gallate was modified on platinum nanoparticles.

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Abstract

The invention discloses a noble metal nanoparticle modified by a small drug molecule and its preparation method and application. The preparation method comprises: placing a noble metal target material in a drug small molecule solution, and using a pulse laser to ablate the noble metal target material to prepare the drug Noble metal nanoparticles modified by small molecules; the particle size of the prepared noble metal nanoparticles modified by small drug molecules is 2-10nm, and the modification amount of small drug molecules is 0.05-0.8wt%; it can be applied to the preparation of treatment or prevention of neurodegeneration Drugs for the disease Alzheimer's disease. The preparation method provided by the present invention is simple in operation and quick in response, and the prepared noble metal nanoparticles modified by small drug molecules have the effect of significantly inhibiting the aggregation of amyloid Aβ, and have broad application prospects in the research and development of drugs for the treatment of Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and relates to a precious metal nanoparticle modified by small drug molecules, a preparation method and application thereof. Background technique [0002] There are many kinds of noble metal nanoparticles from a wide range of sources, including gold nanoparticles, silver nanoparticles and platinum nanoparticles, etc., and they have the advantages of stable performance and easy preparation; in addition, some noble metal nanoparticles can pass through the blood-brain barrier. Wide range of applications. However, limited by their poor biocompatibility, noble metal nanoparticles have certain limitations in the application of nanomedicine. [0003] Small pharmaceutical molecules that inhibit polypeptide aggregation include epigallocatechin gallate, pentagalloyl glucose, proanthocyanidin B, baicalein, and oleuropein, all of which can be extracted from plants, with abundant sources and easy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/52A61K47/69A61K31/353A61P25/28A61K31/7048B22F1/00B22F9/02B82Y40/00
CPCA61K47/52A61K47/6923A61P25/28A61K31/353A61K31/7048B82Y40/00B22F9/02B22F1/054
Inventor 杨蓉张雨飞韩秋森刘学良王新环王琛
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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