Nanometer gel preparation with dual slow release effect and preparation method thereof

A nano-gel, sustained-release technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, capsule delivery, etc. Change the problem of low ability to achieve the effect of benefiting the body's absorption, high encapsulation rate, and promoting absorption

Active Publication Date: 2018-10-19
EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the scheme described in the above-mentioned patent application, the components: digalactosyldiacylglycerol and other lipid substances can also form gel preparations during the mutual fusion process of polar solvents, but the lamellar liquid crystal structure viscosity of the gel High, causing its swelling step to be extremely slow, and the viscosity of its gel formulation is not changed by temperature changes. When the human body or other living organisms use in

Method used

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  • Nanometer gel preparation with dual slow release effect and preparation method thereof
  • Nanometer gel preparation with dual slow release effect and preparation method thereof
  • Nanometer gel preparation with dual slow release effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] This embodiment provides a nanogel preparation with double sustained release, which is prepared from the following raw materials in weight percentage:

[0046] Paclitaxel 10%

[0047] Liquid crystal material 40% (phospholipid: glycerol: co-solvent = 6: 1: 0.5)

[0048] Rheology modifier 50%

[0049] The preparation method of the nanogel preparation with double sustained release is as follows:

[0050] S1 Weigh phosphatidylcholine, diolein, ethanol and 10% paclitaxel in a weight ratio of 6:1:0.5 according to 40% of the total weight and mix and stir for 30 minutes;

[0051] S2 adding a small amount of water to the precursor solution obtained in S1 for high-shear dispersion, and then performing high-pressure homogenization of the obtained mixture to obtain drug-loaded liquid crystal nanoparticles;

[0052] S3, then add 50% of the total weight of poloxamer 407 to the mixed solution of S2, stir slowly for 2 hours, and control the temperature at about 4°C, so that the syst...

Embodiment 2

[0055] This embodiment is basically the same as Embodiment 1, the difference lies in the following aspects:

[0056] A nanogel preparation with double sustained release and a preparation method thereof, prepared from the following raw materials in percentage by weight:

[0057] Paclitaxel 10%

[0058] Liquid crystal material 40% (phospholipid: glycerol: co-solvent = 10: 4: 1.5)

[0059] Rheology modifier 50%

[0060] The release efficiency of the nanogel preparation prepared in this example with double sustained release was investigated, and the encapsulation rate was 82%, and the cumulative release rate within one week was 33%.

Embodiment 3

[0062] This embodiment is basically the same as Embodiment 1, the difference lies in the following aspects:

[0063] A nanogel preparation with double sustained release and a preparation method thereof, prepared from the following raw materials in percentage by weight:

[0064] Paclitaxel 10%

[0065] Liquid crystal material 40% (phospholipid: glycerol: co-solvent = 8: 2: 1)

[0066] Rheology modifier 50%

[0067] The release efficiency of the nanogel preparation prepared in this example with double sustained release was investigated, and the encapsulation rate was 86%, and the cumulative release rate within one week was 30%.

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Abstract

The invention relates to a nanometer gel preparation with a dual slow release effect and a preparation method thereof. The nanometer gel preparation is prepared from 0.001 to 10 weight percent of preloaded medicine, 40 to 70 weight percent of ingredient A liquid crystal materials and 20 to 50 weight percent of ingredient B rheology control agents. The nanometer gel preparation has the dual slow release effect, and has the advantages that the water solubility and the fat solubility of the medicine can be greatly improved; in addition, the rheology control agents are used, so that the gel viscosity can be obviously improved along the temperature rising; at the skin temperature, good viscosity can be maintained; the nanometer gel preparation is applicable to a transdermal drug delivery system; the formed gel preparation can realize the long release time in the body; the absorption speed of the medicine in the body can be obviously improved; the medicine bioavailability is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a nanogel preparation with double sustained-release effects and a preparation method thereof. Background technique [0002] Gel is a new drug dosage form that has emerged in recent years. The research abroad is earlier and the development is faster. Domestic development started from hospital preparations, and now a variety of gels have been approved by the state, showing more advantages and effects of gels. The more commonly used routes of administration for gels are transdermal administration, oral administration, eye administration, nasal cavity administration, vaginal administration and rectal administration. Different administration routes can receive high drug concentrations. , Satisfactory effect of duration of action. The gel has the characteristics of fast absorption, high bioavailability, good biocompatibility, and uniform texture, easy to spread ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/10A61K9/51A61K47/24A61K47/14A61K45/00
CPCA61K9/06A61K9/5123A61K31/337A61K45/00A61K47/10
Inventor 罗亮黄丽萍孟凡玲
Owner EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH
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