Nanometer gel preparation with dual slow release effect and preparation method thereof

Abstract

The invention relates to a nanometer gel preparation with a dual slow release effect and a preparation method thereof. The nanometer gel preparation is prepared from 0.001 to 10 weight percent of preloaded medicine, 40 to 70 weight percent of ingredient A liquid crystal materials and 20 to 50 weight percent of ingredient B rheology control agents. The nanometer gel preparation has the dual slow release effect, and has the advantages that the water solubility and the fat solubility of the medicine can be greatly improved; in addition, the rheology control agents are used, so that the gel viscosity can be obviously improved along the temperature rising; at the skin temperature, good viscosity can be maintained; the nanometer gel preparation is applicable to a transdermal drug delivery system; the formed gel preparation can realize the long release time in the body; the absorption speed of the medicine in the body can be obviously improved; the medicine bioavailability is improved.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a nanogel preparation with double sustained-release effects and a preparation method thereof. Background technique

[0002] Gel is a new drug dosage form that has emerged in recent years. The research abroad is earlier and the development is faster. Domestic development started from hospital preparations, and now a variety of gels have been approved by the state, showing more advantages and effects of gels. The more commonly used routes of administration for gels are transdermal administration, oral administration, eye administration, nasal cavity administration, vaginal administration and rectal administration. Different administration routes can receive high drug concentrations. , Satisfactory effect of duration of action. The gel has the characteristics of fast absorption, high bioavailability, good biocompatibility, and uniform texture, easy to spread ...

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