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Pediatric acetaminophen Huang Namin granule and preparation method thereof

A technology of children's aminophenol Huang Namin granules and acetaminophen, which is applied in the field of medicine, can solve problems such as the loss of artificial bezoar bilirubin and the impact on the efficacy of artificial bezoar, and is suitable for large-scale promotion and application, and improves medication compliance. The effect of sex and bilirubin loss is small

Active Publication Date: 2019-03-19
广东宏远集团药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods usually lead to the loss of bilirubin, the main medicinal component in artificial bezoar, during the process of inclusion or microencapsulation, which seriously affects the efficacy of artificial bezoar.

Method used

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  • Pediatric acetaminophen Huang Namin granule and preparation method thereof
  • Pediatric acetaminophen Huang Namin granule and preparation method thereof
  • Pediatric acetaminophen Huang Namin granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, artificial bezoar clathrate L1

[0028] S1, taking artificial bezoar and dissolving it in an ethanol solution with a volume fraction of 75%, to obtain an artificial bezoar ethanol solution;

[0029] S2. Take hydroxypropyl-β cyclodextrin with a degree of substitution of 6.4 and a degree of substitution of 9.2 and dissolve it in water to obtain an aqueous solution of a mixture of hydroxypropyl-β-cyclodextrin, wherein the hydroxypropyl-β-cyclodextrin mixture is substituted in the aqueous solution The proportion of hydroxypropyl-beta cyclodextrin with a degree of 9.2 is 8.5wt%;

[0030] S3. Take the artificial bezoar ethanol solution and add it dropwise to the aqueous solution of the hydroxypropyl-β-cyclodextrin mixture in a gradually decreasing manner, stir at 27°C for 45 minutes, and dry to obtain final product; among them, artificial bezoar and hydroxypropyl -The mass ratio of the β-cyclodextrin mixture is 1:3; wherein, adding in a gradually decreasing man...

Embodiment 2

[0047] Embodiment 2, children's paracetamol Huang Namin granules

[0048]

[0049] Preparation:

[0050] Fully mix artificial bezoar clathrate with acetaminophen and sucrose to obtain a mixed medicinal powder; dissolve the chlorpheniramine maleate in purified water to make an aqueous solution, add it to the mixed medicinal powder, stir for 25 minutes, add The purified water is made into a suitable soft material, and after granulation, drying and sizing, the pediatric acetaminophen huangnamin granules are obtained.

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Abstract

The invention belongs to the field of medicines, and particularly relates to a pediatric paracetamol and a preparation method thereof. The pediatric paracetamol is prepared from paracetamol, calculusbovis factitius clathrate compounds, chlorpheniramine maleate and the rest sucrose. Hydroxypropyl-beta cyclodextrin with different substitutions serves as a subject, calculus bovis factitius serves asan object, and the calculus bovis factitius clathrate compounds are prepared by the aid of an existing clathrate technique. The calculus bovis factitius clathrate compounds in the pediatric paracetamol is high in clathrate rate, the clathrate rate can reach 95% or more, bilirubin loss is low, bad smell is omitted, drug taste is remarkably improved as compared with the prior art, the drug compliance of a drug user is improved, and the pediatric paracetamol is suitable for large-scale popularization and application.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to infantile paracetamol huangnamin granules and a preparation method thereof. Background technique [0002] Pediatric paracetamol Huang Namin Granules are mainly used to relieve fever, headache, sore limbs, sneezing, runny nose and other symptoms caused by common cold and influenza in children. The prescription included in the national drug standard is: 125g of acetaminophen, 5g of artificial bezoar, 0.5g of chlorpheniramine maleate and appropriate amount of auxiliary materials. In this prescription, artificial bezoar is usually processed by mixing bovine gall powder, cholic acid, hyodeoxycholic acid, taurine, bilirubin, cholesterol and trace components. , stench and bitter taste, often lead to nausea, vomiting and other adverse reactions in children and infants when taking Pediatric Paracetamol Huang Namin Granules, which reduces the medication compliance of children and infan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/69A61K35/413A61P11/00A61P29/00A61K31/167A61K31/4402
CPCA61K9/1682A61K31/167A61K31/4402A61K35/413A61K47/6951A61P11/00A61P29/00A61K2300/00
Inventor 黄金维罗四通蒋琼毛锐强
Owner 广东宏远集团药业有限公司