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Clarithromycin capsule

A technology of clarithromycin and capsules, which is applied in the field of clarithromycin preparations, can solve the problems of large single tablet volume and difficulty in swallowing, and achieve the effects of safe taking, easy swallowing, and increased compliance

Inactive Publication Date: 2018-10-23
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the single tablet dosage of clarithromycin is relatively large, which is 250mg. In order to make tablets with stable content, a large amount of fillers need to be added, resulting in large single tablet volume and difficulty in swallowing, which increases the difficulty of taking medicine for patients, especially in the pharynx. patients with local infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A clarithromycin capsule, comprising 25 parts by weight of clarithromycin, 5 parts by weight of an adhesive, 15 parts by weight of a filler, 2 parts by weight of a glidant, and 3 parts by weight of a gastric-soluble coating premix. ;

[0030] The preparation method of clarithromycin capsule, comprises the following steps:

[0031] 1) Weigh 25 parts by weight of clarithromycin, 2 parts by weight of sodium carboxymethylcellulose, and 15 parts by weight of cornstarch, and place them in an extrusion spheronizer at 200-400r / min and mix for 1-2min;

[0032] 2) Add 3 parts by weight of sodium carboxymethylcellulose into purified water, add it to the mixture described in 1), and mix at 100-200r / min for 2-5min to make a soft material;

[0033] 3) Pass the soft material mentioned in 2) through a 20-30 mesh screen to make granules, and make pellet cores in a spheronizer at 1000-1500r / min;

[0034] 4) Put the pellet core described in step 3) into a fluidized bed pellet coating ma...

Embodiment 2

[0039] A clarithromycin capsule, comprising 25 parts by weight of clarithromycin, 5 parts by weight of an adhesive, 15 parts by weight of a filler, 2 parts by weight of a glidant, and 3 parts by weight of a gastric-soluble coating premix. ;

[0040] The preparation method of clarithromycin capsule, comprises the following steps:

[0041] 1) Weigh 25 parts by weight of clarithromycin, 2 parts by weight of copovidone, and 15 parts by weight of cornstarch, and place them in an extrusion spheronizer at 200-400r / min and mix for 1-2min;

[0042] 2) Add 3 parts by weight of copovidone into purified water, add it to the mixture described in 1), and mix at 100-200r / min for 2-5min to make a soft material;

[0043] 3) Pass the soft material mentioned in 2) through a 20-30 mesh screen to make granules, and make pellet cores in a spheronizer at 1000-1500r / min;

[0044] 4) Put the pellet core described in step 3) into a fluidized bed pellet coating machine, and fluidize and dry at 40-50°C...

Embodiment 3

[0049] A clarithromycin capsule, comprising 25 parts by weight of clarithromycin, 5 parts by weight of an adhesive, 15 parts by weight of a filler, 2 parts by weight of a glidant, and 3 parts by weight of a gastric-soluble coating premix. ;

[0050] The preparation method of clarithromycin capsule, comprises the following steps:

[0051] 1) Weigh 25 parts by weight of clarithromycin, 1 part by weight of sodium carboxymethyl cellulose, and 15 parts by weight of cornstarch, and place them in an extrusion spheronizer at 200-400r / min and mix for 1-2min;

[0052] 2) Add 4 parts by weight of sodium carboxymethylcellulose into purified water, add it to the mixture described in 1), and mix at 100-200r / min for 2-5min to make a soft material;

[0053] 3) Pass the soft material mentioned in 2) through a 20-30 mesh screen to make granules, and make pellet cores in a spheronizer at 1000-1500r / min;

[0054]4) Put the pellet core described in step 3) into a fluidized bed pellet coating mac...

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PUM

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Abstract

The invention relates to the technical field of clarithromycin preparations, in particular to a clarithromycin capsule. The clarithromycin capsule comprises clarithromycin, a filling agent, a binder,a flow aid, a medicinal hollow capsule shell and gastric-soluble coating premix. The clarithromycin capsule has the advantages that the clarithromycin, the filling agent and the binder are prepared into pellets with certain granularity, the stability and flowability of the pellets are increased through the gastric-soluble coating premix and the flow aid, the quality of the clarithromycin capsule is increased, and drug use safety is increased.

Description

technical field [0001] The invention relates to the technical field of clarithromycin preparations, in particular to a clarithromycin capsule. Background technique [0002] Clarithromycin (CLM, also known as erythromycin methoxy), its chemical structure is changed from -OH at the A6 position of erythromycin to -OCH 3 , is a new generation of macrolide antibiotics. In addition to having the microbiological activity of erythromycin and oral β-lactam drugs, it has stronger antibacterial activity against Haemophilus influenzae and atypical pathogens than the latter two In addition, after the hydroxyl group on the 6-position of the large lactone ring is replaced by a methoxy group, the pharmacokinetics show: stable to gastric acid, high oral bioavailability, long clearance half-life and strong tissue penetration. , thus correspondingly reducing the dose and administration frequency, relatively reducing toxicity and adverse reactions, thus obtaining excellent clinical evaluation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K9/50A61K47/38A61K47/32A61K31/7048A61P31/04
CPCA61K9/5026A61K9/5042A61K31/7048A61P31/04
Inventor 张汉华朱正标曹群闫海粟范小雪
Owner 江苏黄河药业股份有限公司
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