Substituted imidazolium compounds, and preparation method, pharmaceutical compositions and application thereof
A technology of compounds and substituents, applied in the fields of substituted imidazolium salt compounds, their preparation, pharmaceutical compositions and their applications, which can solve the problems of non-cell permeability and limited application
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[0194] In another aspect, the present invention also provides a method for preparing the compound described in any of the above technical schemes, comprising the following steps:
[0195]
[0196] Reaction conditions: (a) substitution reaction of brominated hydrocarbons; (b) substitution reaction of brominated hydrocarbons or
[0197]
[0198] Reaction conditions: (a) substitution reaction of brominated hydrocarbons under alkaline conditions (such as sodium hydride, sodium tert-butyl alkoxide, etc.); (b) substitution reaction of brominated hydrocarbons.
[0199] On the other hand, the present invention also provides the compound described in any of the above-mentioned technical schemes, its stereoisomer, its prodrug, or its pharmaceutically acceptable salt or pharmaceutically acceptable solvate and the compound containing the compound The pharmaceutical composition is used in the preparation of drugs for inhibiting cholesterol synthesis, drugs for reducing fatty acid syn...
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[0208] The implementation of the present invention will be described in detail below through specific examples, but they should not be construed as limiting the present invention in any case.
[0209]
[0210] The compounds of the above general formula are divided into two types of synthetic preparation.
[0211] The general formula of compound I
[0212]
[0213] in,
[0214] The synthetic method of compound IA-general formula
[0215]
[0216] Preparation of Compound 1
[0217]
[0218] The compound 2-methylimidazole (821mg, 10mmol) was dissolved in 10mL of ethanol, and bromoalkane (12mmol) was added to the solution and stirred in an oil bath at 70°C until the reaction of 2-methylimidazole was complete (LC-MS track). Stop the reaction, concentrate the system, and perform silica gel column chromatography (dichloromethane / methanol) to obtain compound 1-alkyl-2-methylimidazole (1).
[0219] Preparation of Compound IA
[0220]
[0221] Multi-substituted benz...
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