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Preparation method for resin used for antibiotics purification

A technology of antibiotics and resins, applied in the field of resin preparation, can solve the problem that the purification rate of resins is not greatly improved, etc.

Inactive Publication Date: 2018-10-26
安徽皖东树脂科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the domestic use of macroporous adsorption resins for separation, extraction, concentration, and purification of antibiotics covers all types of known antibiotics, but the purification rate of the resin used is not much improved compared with the traditional solvent extraction method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 5 parts of styrene, 100 parts of acrylic acid and 10 parts of divinylbenzene as monomers by weight ratio, add 10-% porogen isooctane of the monomer mass, and add 1% benzoyl oxide of the monomer mass As an initiator, fully mix and stir in a reactor for 10 hours to obtain an oil phase; get 50 parts of dispersant polyvinyl alcohol and add 700 parts of deionized water to form a water phase, and fully stir and mix the water phase and the oil phase in a reactor, Heat to 40°C, react for 2H, gradually heat to 70°C, react for 4H, then warm to 90°C, react for 8H, make the mixture gradually solidify into milky white particles, and obtain white balls; use chloromethylated solvent to obtain white balls Swell, react for 6H under the action of the catalyst ferric chloride, wash and dry to obtain chlorine spheres; move the obtained chlorine spheres into the elution column, pass in water vapor at a temperature of 140°C as the eluent, elute for 4H, and elute The remaining porogen in...

Embodiment 2

[0018] Take 10 parts of styrene, 200 parts of acrylic acid and 20 parts of divinylbenzene as monomers by weight ratio, add 10-15% porogen isooctane of the monomer mass, and add 2% oxybenzone of the monomer mass Acyl as an initiator, fully mixed and stirred in a reactor for 12 hours to obtain an oil phase; take 100 parts of dispersant polyvinyl alcohol and add 700 parts of deionized water to form a water phase, and fully stir and mix the water phase and oil phase in a reactor , heated to 50°C, reacted for 2H, gradually heated to 80°C, reacted for 4H, then heated to 100°C, reacted for 8H, so that the mixed solution gradually solidified into milky white particles, and white balls were obtained; the obtained white balls were chloromethylated The solvent expands, reacts for 6H under the action of the catalyst ferric chloride, and obtains chlorine spheres after washing and drying; move the obtained chlorine spheres into an elution column, and pass in water vapor at a temperature of 1...

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Abstract

The invention discloses a preparation method for resin used for antibiotics purification. The preparation method comprises the following steps that 1) an oil phase is prepared; 2) a water phase is prepared; 3) the oil phase reacts with the water phase to make mixed liquid gradually solidified into milk white particles, and white balls are obtained; 4) the obtained white balls are swelled by usingchloromethylation solvent, under the effect of a ferric chloride catalyst, the reaction lasts for 6 hours, after washing and drying, chlorine balls are obtained; 5) residual pore-foaming agent in thechlorine balls is eluted, and macropore cationic resin semi-finished products are prepared; 6) 100 ml of wet resin is added into 300 ml of caustic soda liquid with the concentration of 20-25%, the reaction lasts for 8-12 hours at 75-80 DEG C, after the reaction is finished, packing is conducted, the resin is washed with deionized water with the volume same with that of the resin, column chromatography isolation by using hydrochloric acid lasts for 4-5 hours, the resin is washed with deionized water to neutral, the macropore weakly acidic cation exchange resin is prepared, and by adopting the method, the purification rate of the prepared resin used for antibiotics purification is significantly improved.

Description

technical field [0001] The invention relates to the field of antibiotic purification, in particular to a method for preparing a resin used for antibiotic purification. Background technique [0002] Common separation and purification methods for antibiotics mainly include solvent extraction, adsorption, ion exchange, precipitation and crystallization, chromatographic separation, etc. Solvent extraction uses the difference in the distribution coefficient of the solute between two immiscible phases to make the It is a method of selectively transferring from one solvent to another to obtain purification or concentration. This method is simple to operate, but the purification rate is not very high; the adsorption method uses the molecular attraction between the adsorbent and the antibiotic to separate the antibiotic Adsorbed on the adsorbent, commonly used adsorbents include activated carbon, alumina, macroporous adsorption resin, etc. Macroporous adsorption resin is one of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08J7/02C08F220/06C08F212/08C08F212/36B01J20/26B01J20/30
CPCB01J20/261B01J2220/4812C08F220/06C08J7/02C08J9/28C08J2201/0502C08J2333/02C08F212/08C08F212/36
Inventor 薛兆能
Owner 安徽皖东树脂科技有限公司
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