25mg amitriptyline thin-film coating tablet prescription and technological procedure

A technology of amitriptyline and film coating, applied in the field of medicine, can solve the problems of difficulty in decomposing, regulating the mood of patients, and unfavorable absorption by patients, and achieve the effects of improving taste, improving mood, and being easy to decompose and absorb

Inactive Publication Date: 2018-11-02
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a 25mg amitriptyline film-coated tablet prescription and process regulations, which solves the problem that the existing amitriptyline film-coated tablet drug coagulates into a ta

Method used

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  • 25mg amitriptyline thin-film coating tablet prescription and technological procedure

Examples

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example 1

[0032] A 25mg amitriptyline film-coated tablet prescription is characterized in that: it is made of the following components by weight, tablet core: 84 parts by weight of calcium hydrogen phosphate dihydrate, 1 part by weight of cornstarch, 15 parts by weight of purified water, 20 parts by weight of amitriptyline hydrochloride, 5 parts by weight of lactose, 9 parts by weight of corn starch, 6 parts by weight of microcrystalline cellulose, 0.8 parts by weight of anhydrous silica gel, 0.5 parts by weight of stearic acid, and 0.2 parts by weight of magnesium stearate, Coating: 5 parts by weight of coating powder, 25 parts by weight of isopropanol, and 25 parts by weight of purified water.

[0033] A kind of technological specification of 25mg amitriptyline film-coated tablet prescription, comprises the following steps,

[0034] (1), lactose, cornstarch, microcrystalline cellulose, anhydrous silica gel, stearic acid, magnesium stearate, amitriptyline hydrochloride, calcium hydroge...

example 2

[0052] A 25mg amitriptyline film-coated tablet prescription is characterized in that: it is made of the following components by weight, tablet core: 85.5 parts by weight of calcium hydrogen phosphate dihydrate, 2 parts by weight of cornstarch, 15.5 parts by weight of purified water, 25 parts by weight of amitriptyline hydrochloride, 6 parts by weight of lactose, 10 parts by weight of corn starch, 6.5 parts by weight of microcrystalline cellulose, 1.3 parts by weight of anhydrous silica gel, 1 part by weight of stearic acid, 0.5 parts by weight of magnesium stearate, Coating: 5.5 parts by weight of coating powder, 30 parts by weight of isopropanol, and 30 parts by weight of purified water.

[0053] A kind of technological specification of 25mg amitriptyline film-coated tablet prescription, comprises the following steps,

[0054] (1), lactose, cornstarch, microcrystalline cellulose, anhydrous silica gel, stearic acid, magnesium stearate, amitriptyline hydrochloride, calcium hydr...

example 3

[0072] A 25mg amitriptyline film-coated tablet prescription is characterized in that: it is made of the following components by weight, tablet core: 87 parts by weight of calcium hydrogen phosphate dihydrate, 3 parts by weight of cornstarch, 16 parts by weight of purified water, 30 parts by weight of amitriptyline hydrochloride, 7 parts by weight of lactose, 11 parts by weight of cornstarch, 7 parts by weight of microcrystalline cellulose, 1.8 parts by weight of anhydrous silica gel, 1.5 parts by weight of stearic acid, 0.8 parts by weight of magnesium stearate, Coating: 6 parts by weight of coating powder, 35 parts by weight of isopropanol, and 35 parts by weight of purified water.

[0073] A kind of technological specification of 25mg amitriptyline film-coated tablet prescription, comprises the following steps,

[0074] (1), lactose, cornstarch, microcrystalline cellulose, anhydrous silica gel, stearic acid, magnesium stearate, amitriptyline hydrochloride, calcium hydrogen p...

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Abstract

The invention provides a 25mg amitriptyline thin-film coating tablet prescription and a technological procedure, and relates to the technical field of medicines. The 25mg amitriptyline thin-film coating tablet prescription is prepared from the following components in parts by weight: tablet cores: 85.49 parts of hydryoxyapetite, 1.84 parts of corn starch, 15.56 parts of purified water, 25 parts ofamitriptyline hydrochloride, 6 parts of lactose, 9.9 parts of corn starch, 6.5 parts of microcrystalline celluloses, 1.3 parts of anhydrous silica gel, 1 part of stearic acid and 0.5 part of magnesium stearate; and a coating: 5.54 parts of coating powder, 30 parts of isopropanol and 30 parts of purified water. The technological procedure comprises the steps of granulating a prepared granulating solution, drying, sieving and meshing; dry-method granulating; totally mixing, and tabletting to form table cores; and preheating the tablet cores, processing the coating and drying. The bitter taste is adjusted through the corn starch, the color of the outer surface is improved through the coating, the mood of a patient is improved favorably, by the anhydrous silica gel, the 25mg amitriptyline thin-film coating tablet prescription is easily decomposed and absorbed, and health of the patient is facilitated.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a prescription and a technical procedure of a 25mg amitriptyline film-coated tablet. Background technique [0002] Amitriptyline is commonly used as its hydrochloride, which is colorless crystals or white, off-white powder; odorless or almost odorless, bitter, burning sensation, followed by numbness. Soluble in water, methanol, ethanol or chloroform, almost insoluble in ether. The melting point is 195-199°C. Amitriptyline is the most commonly used clinical tricyclic antidepressant, its pharmacological effect is to block the reuptake of norepinephrine and 5-hydroxytryptamine in nerve endings, thereby increasing the concentration of transmitters in the synaptic cleft and promoting synaptic stimulation. Play an antidepressant effect by triggering the transmission function. Its antidepressant effect is similar to that of imipramine, which can improve the mood of patients with dep...

Claims

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Application Information

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IPC IPC(8): A61K9/30A61K31/135A61K47/36A61P25/24
CPCA61K9/282A61K31/135A61K47/36A61P25/24
Inventor 高煜
Owner HUAYI PHARMA ANHUI CO LTD
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