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Prunella vulgaris mulberry leaf chrysanthemum pharmaceutical preparation, preparation method and application thereof

A pharmaceutical preparation, the technology of Xiasangju, applied in the field of Xiasangju pharmaceutical preparations, can solve the problems of low extraction rate of active ingredients in medicinal materials, affecting the quality and curative effect of preparations, and high sugar content in Xiasangju granules, achieving short decoction time, convenient administration, and easy extraction. The effect of using less water

Inactive Publication Date: 2018-11-02
ARTEPHARM CO LTD CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high sugar content of Xia Sangju Granules, the dosage is large, so people with diabetes and obesity should not take it.
[0004] At present, the preparation process of Xiasangju granules basically follows the traditional process method. The medicinal materials are directly decocted and extracted with water without pretreatment. The extraction rate of active ingredients in the medicinal materials is low, and the extraction time of decoction is long. The quality and curative effect of preparations. With the continuous improvement of clinical requirements for drug quality and effect and the continuous development of pharmaceutical technology, the current technology can no longer meet the current needs. There is an urgent need for a preparation with higher active ingredients and less material loss. technology to better play the medicinal value of Xiasangju preparation

Method used

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  • Prunella vulgaris mulberry leaf chrysanthemum pharmaceutical preparation, preparation method and application thereof
  • Prunella vulgaris mulberry leaf chrysanthemum pharmaceutical preparation, preparation method and application thereof
  • Prunella vulgaris mulberry leaf chrysanthemum pharmaceutical preparation, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A medicinal preparation of mulberry chrysanthemum, comprising the following raw materials in parts by weight: 1500 parts of Prunella vulgaris, 525 parts of mulberry leaves, 240 parts of wild chrysanthemum, 40 parts of silicon dioxide and 1 part of magnesium stearate.

[0022] The preparation method of described Xia Sangju medicinal preparation, concrete steps are as follows:

[0023] Step 1: Spray Prunella vulgaris, mulberry leaves, and wild chrysanthemums with liquid nitrogen for cooling and embrittlement for 4 minutes, and pulverize them into coarse powder with an ultra-low temperature pulverizer;

[0024] Step 2, add wild chrysanthemum flour to water and the first compound enzyme, the first compound enzyme is a mixture of pectinase and hemicellulase with a mass ratio of 1:2, adjust the pH to 4.8, heat up to 50°C and soak for 42 Minutes, stirring once every 10 minutes to obtain the wild chrysanthemum enzymatic hydrolysis solution, then reflux extraction to collect the...

Embodiment 2

[0028] A medicinal preparation of Prunella vulgaris, comprising 2000g of Prunella vulgaris, 600g of mulberry leaves, 320g of wild chrysanthemum, 60g of silicon dioxide and 3g of magnesium stearate.

[0029] The preparation method of described Xia Sangju medicinal preparation, concrete steps are as follows:

[0030] Prunella vulgaris, mulberry leaves, and wild chrysanthemum were sprayed with liquid nitrogen at -196°C for cooling and embrittlement for 5 minutes (the weight ratio of medicinal materials to liquid nitrogen was 10:1), and they were pulverized into coarse powder with an ultra-low temperature pulverizer. Add 5 times the weight of water to wild chrysanthemum, add 5g of the first compound enzyme, add oxalic acid to adjust the pH to 5.0, raise the temperature to 50°C and soak for 30 minutes, stir once every 10 minutes, the first compound enzyme is a mass ratio of 1:2 The mixture of pectinase and hemicellulase is used to obtain the enzymatic hydrolyzate of the wild chrysa...

Embodiment 3

[0033] A medicinal preparation of Prunella vulgaris, comprising 2300g of Prunella vulgaris, 700g of mulberry leaves, 300g of wild chrysanthemum, 70g of silicon dioxide and 2g of magnesium stearate.

[0034] The preparation method of described Xia Sangju medicinal preparation, concrete steps are as follows:

[0035] Prunella vulgaris, mulberry leaves, and wild chrysanthemum were sprayed with liquid nitrogen at -196°C for cooling and embrittlement for 5 minutes (the weight ratio of medicinal materials to liquid nitrogen was 10:1), and were pulverized into coarse powder with an ultra-low temperature pulverizer. Add 5 times the weight of water to wild chrysanthemum, add 4.6g of the first compound enzyme, add acetic acid to adjust the pH to 5.0, raise the temperature to 50°C and soak for 40 minutes, stir once every 10 minutes, the mass ratio of the first compound enzyme is 1:2 The mixture of pectinase and hemicellulase to obtain the wild chrysanthemum hydrolyzate, and then reflux e...

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Abstract

The invention discloses a prunella vulgaris mulberry leaf chrysanthemum pharmaceutical preparation, a preparation method and application thereof. The pharmaceutical preparation comprises the followingraw materials by weight: 1 500-2500 parts of prunella vulgaris, 525-875 parts of mulberry leaf, 240-400 parts of wild chrysanthemum, 40-80 parts of silicon dioxide and 1-4 parts of magnesium stearate. The preparation method provided by the invention can minimize the effective ingredient loss of Chinese medicinal materials, performs ultra-low temperature crushing of the Chinese herbal materials, the effective ingredients of the Chinese medicinal materials cannot be lost due to high temperature degradation, compound enzymes are employed for extraction, so that effective ingredients in cells canbe dissolved out easily, the extraction rate of medicinal effective ingredients is high, the decoction time is short, at the same time, the viscosity of the extracted liquid is lowered, the filtration rate is increased, and the water hold rate of the herb residue is reduced. The product provided by the invention has more extensive target users, and is more convenient to take.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicinal preparation of xiasangju. Background technique [0002] Cold is the most common acute respiratory infectious disease, which is mostly self-limiting, but the incidence is relatively high. In addition to taking cold medicine for treatment when a cold occurs, people also take medicine to prevent colds. [0003] Xia Sangju Granules is a Chinese patent medicine widely used clinically to prevent and treat colds, clear away heat and detoxify. Because Xia Sangju Granules have mild and long-lasting effects, and have no side effects such as "sleepiness and fatigue" of western medicines for colds, they have been favored by the masses for a long time. People's favorite. However, due to the high sugar content of Xia Sangju Granules, the dosage is large, so people with diabetes and obesity should not take it. [0004] At present, the preparation process of Xiasangju gr...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61K9/20A61K9/48A61P29/00A61P9/12A61P11/04A61P1/08A61P27/16
CPCA61K9/1611A61K9/1617A61K9/2009A61K9/2013A61K36/287A61K36/536A61K36/605A61K2236/15A61K2236/19A61K2236/331A61K2236/39A61K2236/53A61P1/08A61P9/12A61P11/04A61P27/16A61P29/00A61K2300/00
Inventor 张志坚张加颂杨兆丽陈泽韩庄志梅
Owner ARTEPHARM CO LTD CHINA
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