Tissue sealing material and its preparation method and sealing product

Abstract

The invention provides a tissue occlusion material, a method for preparing the same and an occlusion product. The tissue occlusion material comprises a matrix and wet-state adhesion layers. Cellosilkwith the diameters ranging from 10 nm to 100 micrometers is interwoven to form the matrix, and the matrix is at least partially provided with porous structures; the wet-state adhesion layers are arranged on at least one surface of the matrix, the surfaces of the matrix are in contact with adhesion solution to form the wet-state adhesion layers, the adhesion solution comprises amino compounds and buffer solution, and the amino compounds are dissolved in the buffer solution. The tissue occlusion material, the method and the occlusion product have the advantages that the tissue occlusion materialis excellent in adhesion property and burst strength and appropriate in elongation at break, and can be effectively adhered with the surfaces of organisms or the surfaces of solid organs; the tissueocclusion material is further provided with porous network micro-structures formed by the cellosilk, and accordingly wound healing and tissue regeneration can be promoted.

Description

technical field [0001] The invention relates to a tissue plugging material, a preparation method thereof and a plugging product, belonging to the field of medical implant materials. Background technique [0002] Tissue closure, such as: hemostasis closure, interstitial fluid leakage closure, etc., is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. Effective hemostasis is the key to relieving patients' suffering and reducing mortality, and rapid and effective hemostasis has become the focus of solving this problem. In daily life, it is inevitable to encounter damage to body tissues caused by various unexpected accidents and disasters. [0003] At present, common hemostatic materials include microporous inorganic materials (zeolites), microporous starch, fibrin glue, gelatin sponge, carboxymethylcellulose soluble hemostatic gauze, α-cyanoacrylate tissue glue...

AI Technical Summary

Problems solved by technology

[0008] Based on the above-mentioned technical problems in the prior art, for example: the adhesion is poor, and it is easy to fall off from the wound; the temperature around the wound is raised to cause a burn wound, which is difficult to heal; the speed of hemostasis and the amount of hemostasis are still not enough for a large number of rapid bleeding Emergency treatment requirements; liquid leakage cannot be stopped quickly; bursting strength is low, etc.

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