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Method for preparing soybean phospholipid with high PC content

A soybean phospholipid content technology, applied in the direction of edible phospholipid composition, chemical instruments and methods, compounds of group 5/15 elements of the periodic table, etc., can solve the problem of limited operation scale or the use of toxic and harmful solvents, expensive equipment, Product purity can not be reached and other problems, to achieve the effect of high efficiency of production process, easier control of quality, and improvement of purification effect

Inactive Publication Date: 2018-11-06
JIANGXI GUOYAO PHARMA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purity of soybean lecithin extracted by traditional organic solvent method is not high, so it can only be applied to traditional industrial fields such as feed, food, cosmetics, etc.
Supercritical fluid extraction, mostly using CO 2 As an extraction agent, due to its poor solubility to lecithin, it is not conducive to the separation of phospholipids, and the equipment is expensive
These above-mentioned extraction methods, because the product purity does not reach the requirement of pharmaceutical grade soybean lecithin, or are limited by the operation scale of equipment or the use of toxic and harmful solvents, etc., all should not be used as pharmaceutical excipients for high-purity soybean lecithin for injection. Promoting and using large-scale production processes

Method used

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  • Method for preparing soybean phospholipid with high PC content
  • Method for preparing soybean phospholipid with high PC content
  • Method for preparing soybean phospholipid with high PC content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A preparation method of soybean lecithin with high PC content, comprising the following steps:

[0043] (1) Add 1 kg of soybean lecithin with a PC (phosphatidylcholine) content of 20%, and solvent I to the reaction kettle successively, the ratio of soybean lecithin to solvent I is 1g:1ml, stir and heat to 45°C and continue to stir for 15min, Cool down to 5°C, filter, wash the filter cake once with acetone, drain, and dry the drained filter cake under reduced pressure at a temperature of 25°C, a pressure of 0.001 MPa, and a drying time of 3 hours to obtain a yellow oil-removed crude product;

[0044] Solvent I is acetone;

[0045] (2) Add the oil-removed crude product and solvent II obtained in step (1) successively to the reaction kettle, the ratio of the oil-removed crude product to solvent II is 1g:1ml, heat to 40°C for leaching for 15min, stir, and cool down to 5°C, Filtrate, wash the filter cake once with solvent II, store the filtrate at a low temperature of 5°C t...

Embodiment 2

[0053] A preparation method of soybean lecithin with high PC content, comprising the following steps:

[0054] (1) Add 1 kg of soybean lecithin and solvent I with a PC (phosphatidylcholine) content of 20% into the reaction kettle successively, the ratio of soybean lecithin to solvent I is 1g:10ml, stir and heat to 50°C and continue to stir for 50min, Cool down to 10°C, filter, wash the filter cake twice with acetone, drain, and dry the drained filter cake under reduced pressure at a temperature of 40°C, a pressure of 0.005 MPa, and a drying time of 10 hours to obtain a yellow oil-removed crude product;

[0055] Solvent I volume ratio is 3:1 acetone and ethanol;

[0056] (2) Add the oil-removed crude product and solvent II obtained in step (1) successively to the reaction kettle, the ratio of the oil-removed crude product to solvent II is 1g:10ml, heat to 60°C for leaching for 60min, stir, cool to 15°C, Filtrate, wash the filter cake with solvent II for 3 times, store the filt...

Embodiment 3

[0064] A preparation method of soybean lecithin with high PC content, comprising the following steps:

[0065] (1) Add 1 kg of soybean lecithin and solvent I with a PC (phosphatidylcholine) content of 20% into the reaction kettle successively, the ratio of soybean lecithin to solvent I is 1g:15ml, stir and heat to 55°C and continue stirring for 90min, Cool down to 20°C, filter, wash the filter cake with acetone 5 times, drain, and dry the drained filter cake under reduced pressure at a temperature of 60°C, a pressure of 0.01 MPa, and a drying time of 15 hours to obtain a yellow oil-removed crude product;

[0066] Solvent I is ethanol;

[0067] (2) Add the oil-removed crude product and solvent II obtained in step (1) successively into the reaction kettle, the ratio of the oil-removed crude product and solvent II is 1g:15ml, heat to 80°C and extract for 120min, stir, cool to 25°C, Filtrate, wash the filter cake with solvent II for 6 times, store the filtrate at a low temperatur...

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Abstract

The invention discloses a method for preparing soybean phospholipid with high PC content. The preparation method comprises pretreating soybean phospholipid through acetone to remove oil, carrying outextraction through an alcohol solution, carrying out adsorption separation through a chromatographic column, carrying out purification through a reverse osmosis filtration process and carrying out vacuum concentration and vacuum low-temperature belt drying. The method has high production efficiency, realizes clean and intelligent production and has strong operability. Through the purification of soybean phospholipid powder, the quality of the finished product is more easily controlled. The soybean phospholipid product has phosphatidylcholine (PC) content of greater than 96%, phosphatidylethanolamine (PE) content of less than 1.5%, phosphatidylinositol (PI) content of less than 0.2%, heavy metal content of less than 5ppm, a peroxide value of 0, hexane-insoluble matter content of less than 0.05%, lysophosphatidylethanolamine and lysophosphatidylcholine total content of less than 1.5% and residual solvent content of less than 0.1% and satisfies requirements on high purity soybean phospholipid for pharmaceutical excipient injection.

Description

technical field [0001] The invention relates to a method for preparing soybean lecithin with high PC content, belonging to the technical field of pharmacy. Background technique [0002] Phospholipids are the basic components of human cells (cell membranes, membrane nuclei, and plastid membranes), and have important relationships with nerves, reproduction, hormones, etc., and have high nutritional and medical values. Phospholipid is a phosphorus-containing lipid substance. Its unique bipolar molecular structure endows it with many unique physical and chemical properties and physiological activities. It is widely used in the food and pharmaceutical industries. It is an ideal emulsifier and excipient for the preparation of various pharmaceutical preparations. raw material. [0003] Phosphatidylcholine (lecithin, PC), the main component of phospholipids, is a hydrophilic phospholipid, and phosphatidylethanolamine (cephalin, PE) is a lipophilic phospholipid. The ratio of PC / PE d...

Claims

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Application Information

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IPC IPC(8): C07F9/10
CPCC07F9/103
Inventor 刘威万义斌葛友群左飞鸿余承祥杨明王海峰张朝军廖时余于莲欣李恒农
Owner JIANGXI GUOYAO PHARMA LLC