A kind of high-strength and high-plastic biodegradable zn-mn-li series zinc alloy and its application

A biodegradable, zinc alloy technology, used in tissue regeneration, medical science, surgery, etc., can solve the problem of not providing zinc alloy yield strength, and achieve the effects of good cell compatibility, easy processing and excellent comprehensive mechanical properties.

Active Publication Date: 2020-06-19
北京尚宁科智医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

No data on the yield strength of the zinc alloy is provided in Patent Document 5

Method used

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  • A kind of high-strength and high-plastic biodegradable zn-mn-li series zinc alloy and its application
  • A kind of high-strength and high-plastic biodegradable zn-mn-li series zinc alloy and its application
  • A kind of high-strength and high-plastic biodegradable zn-mn-li series zinc alloy and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Composition, preparation and performance testing of high strength and high plasticity Zn-Mn-Li ternary zinc alloy.

[0052] The chemical compositions of the four inventive examples of the zinc alloy are shown in Table 1-1, and the balance is Zn. The preparation process of the zinc alloy is: vacuum induction smelting→homogenizing heat treatment→hot extrusion. The vacuum induction smelting uses high-purity Zn blocks and high-purity Mn and Li powders as raw materials, and the ingredients are added to the crucible according to the mass percentage, vacuumed to 5Pa and filled with argon protection, and the power is turned on, and the power is gradually increased to 5KW. After holding at 800°C for 5 minutes, pour it into a metal mold. The homogenization heat treatment is divided into two steps: first, the zinc alloy is kept at 250° C. for 2 hours, and then the furnace temperature is raised to 350° C. for 2 hours, and then air-cooled after being taken out of the furnace. The ...

Embodiment 2

[0066] Composition, preparation and performance testing of high strength and high plasticity Zn-Mn-Li-Mg quaternary alloy.

[0067] The zinc alloy contains 4 alloying elements, 3 of which are essential alloying elements: Zn, Mn and Li, and the 4th is a further added trace alloying element: Mg. The chemical compositions of the four inventive examples of the zinc alloy are shown in Table 2-1, and the balance is Zn. The preparation process of the zinc alloy is: vacuum induction smelting→homogenizing heat treatment→hot extrusion→cold rolling→intermediate heat treatment→drawing. The vacuum induction smelting uses high-purity Zn blocks and high-purity Mn, Li, Mg powders as raw materials, and the smelting is carried out according to the method provided in Example 1. Homogenizing heat treatment and hot extrusion are also carried out according to the method provided in Example 1. The cold rolling is carried out at room temperature with a deformation of 40%. The system of the interme...

Embodiment 3

[0076] Composition, preparation and performance testing of high-strength and high-plasticity Zn-Mn-Li series quinary alloys.

[0077] The zinc alloy contains 5 alloying elements, 3 of which are essential alloying elements: Zn, Mn and Li, and the 4th to 5th are further added alloying elements. The chemical compositions of the four examples of the zinc alloy are shown in Table 3-1, and the balance is Zn. The preparation process of the zinc alloy is: vacuum induction smelting→homogenizing heat treatment→hot extrusion. The vacuum induction smelting uses high-purity Zn block and high-purity Mn, Li, Mg, Cu, Ag powder as raw materials, and the preparation method is carried out according to the method provided in Example 1.

[0078] Samples were cut from the extruded rods of the zinc alloy to be tested for electrochemical corrosion, cytotoxicity and tensile mechanical properties at room temperature. The preparation and testing methods of the above samples were carried out according ...

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Abstract

Provided is high-strength high-plasticity biodegradable Zn-Mn-Li zinc alloy. The alloy comprises 0.01-0.8% of Mn and 0.005-0.4% of Li, wherein Mn is the main alloying element, Li is the minor alloyingelement, and the content of Mn is not lower than the content of Li in the alloy; at least one of Na, K, Ca, Sr, Ti, Mg, Fe, Cu and Ag is selected, wherein the content of Na and the content of K are both not higher than 0.1%, and the total content of Na, K and Li is not higher than 0.4%; the content of Ca, the content of Sr, the content of Ti and the content of Mg are all not higher than 0.2%, andthe total content of Ca, Sr, Ti and Mg is not higher than 0.2%; the content of Fe is not higher than 0.05%; the adding amount of Cu and the adding amount of Ag are not higher than 0.4%, and the totalcontent of Cu and Ag is not higher than 0.4%; and the total content of alloy elements added into the Zn-Mn-Li zinc alloy is not higher than 1.8%, and the balance Zn. The yield strength of the zinc alloy is 250-450 MPa, the tensile strength of the zinc alloy is 350-600 MPa, and the ductility is 20-60%; the degrading rate in simulated body fluid is not higher than 0.15 mm / year; the cytotoxicity tothe L929 cell is at the level 0 or level 1, and good cytocompatibility is presented. The zinc alloy is used for a degradable bracket or other medical implants.

Description

technical field [0001] The invention relates to the composition design, preparation method and application field of a high-strength and high-plastic biodegradable Zn-Mn-Li zinc alloy, belonging to the field of medical implant materials. Background technique [0002] At present, the materials used for medical implants mainly include medical stainless steel, cobalt-chromium alloy, titanium alloy, iron alloy and magnesium alloy. Among them, medical stainless steel, cobalt-chromium alloy, titanium alloy and iron alloy do not degrade or degrade very slowly in the human body, and the implant often needs to be removed through a second operation, which increases the physiological and economic burden of the patient; medical magnesium alloy degrades in the human body The speed is too fast to make it difficult to play the expected role. Zinc is one of the essential trace elements for the human body. An appropriate amount of zinc can enhance human immunity and promote the growth and de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C18/00A61L31/14A61L31/02A61L27/50A61L27/04
CPCA61L27/047A61L27/50A61L31/022A61L31/14A61L2430/02C22C18/00
Inventor 石章智刘雪峰王鲁宁于静
Owner 北京尚宁科智医疗器械有限公司
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