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Comprehensive cyclic production method of D-glucosamine hydrochloride

A technology of glucosamine hydrochloride and glucosamine, applied in amino sugar, sugar derivatives, sugar derivatives and other directions, can solve problems such as environmental pollution, resource waste, etc., to reduce production costs, reduce wastewater discharge, and reduce emissions Effect

Active Publication Date: 2018-11-16
SHANDONG YANGCHENG BIOLOGY TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the waste of resources and environmental pollution problems existing in the production of D-glucosamine hydrochloride by microbial fermentation methods, the present invention provides a comprehensive cycle production method of D-glucosamine hydrochloride, which improves the production of D-glucosamine hydrochloride. The hydrochloride extraction step improves product quality, reduces waste water discharge, fully utilizes various components in the fermentation broth, and avoids resource waste and environmental pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 10m³ fermentation broth, wherein the N-acetyl-D-glucosamine content is 1300kg. The fermented broth is processed as follows:

[0039] (1) Extraction of N-acetyl-D-glucosamine in the fermentation broth: Mix the last batch of ultrafiltration retentate (1m³) with this batch of fermentation broth and then remove impurities and bacteria through the microfiltration membrane. The pore size of the microfiltration process is 0.1 μm, the operating pressure of the microfiltration process is 0.08 MPa, and the operating temperature is 50 ° C; the bacterial suspension obtained by the microfiltration is dried as a feed additive or made into feed protein, and the clear liquid obtained by the microfiltration membrane passes through the ultrafiltration membrane. Filtrate to remove protein, add the ultrafiltration retentate (1m³) obtained by ultrafiltration membrane filtration into the next batch of fermentation broth for internal circulation, the ultrafiltration membrane pore size is...

Embodiment 2

[0044] Take 10m³ fermentation broth, wherein the N-acetyl-D-glucosamine content is 1300kg. The fermented broth is processed as follows:

[0045] (1) Extraction of N-acetyl-D-glucosamine in the fermentation broth: Mix the last batch of ultrafiltration retentate (1m³) with this batch of fermentation broth and then remove impurities and bacteria through the microfiltration membrane. The pore size of the microfiltration process is 0.05μm, the operating pressure of the microfiltration process is 0.1MPa, and the operating temperature is 30°C; the bacterial suspension obtained by the microfiltration is dried as a feed additive or made into feed protein, and the clear liquid obtained by the microfiltration membrane passes through the ultrafiltration membrane. Filtrate to remove protein, add the ultrafiltration retentate (1m³) obtained by ultrafiltration membrane filtration into the next batch of fermentation broth for internal circulation, the ultrafiltration membrane pore size is 800...

Embodiment 3

[0050] Take 10m³ fermentation broth, wherein the N-acetyl-D-glucosamine content is 1300kg. The fermented broth is processed as follows:

[0051] (1) Extraction of N-acetyl-D-glucosamine in the fermentation broth: Mix the last batch of ultrafiltration retentate (1m³) with this batch of fermentation broth and then remove impurities and bacteria through the microfiltration membrane. The pore size of the microfiltration process is 0.1 μm, the operating pressure of the microfiltration process is 0.05 MPa, and the operating temperature is 60 ° C; the bacterial suspension obtained by the microfiltration is dried as a feed additive or made into feed protein, and the clear liquid obtained by the microfiltration membrane passes through the ultrafiltration membrane. Filtrate to remove protein, add the ultrafiltration retentate (1m³) obtained by ultrafiltration membrane filtration into the next batch of fermentation broth for internal circulation, the ultrafiltration membrane pore size is...

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Abstract

The invention discloses a comprehensive cyclic production method of D-glucosamine hydrochloride. At first, N-acetyl-D-glucosamine in fermentation broth is extracted; then, N-acetyl-D-glucosamine crystals are hydrolyzed by hydrochloric acid, a crude product of D-glucosamine hydrochloride is produced; and finally the crude product is refined. During the extraction process, generated bacterial suspension is dried to produce a feed additive or feed proteins; and generated various mother liquors and trapped fluid are cycled and reused. The production method overcomes the shortages that in the priorart, the resources are not comprehensively utilized and wasted, and the environment is polluted; comprehensively and cyclically utilizes the resources, is accord with the green and environment-friendly idea, purifies the environment, promotes the ecological balance, reduces the production cost, and increases the social and economic benefits.

Description

technical field [0001] The invention relates to a method for producing D-glucosamine hydrochloride, in particular to a comprehensive cycle production method of D-glucosamine hydrochloride. Background technique [0002] Glucosamine exists widely in nature and is the basic unit of many important polysaccharides in biological cells, especially in the exoskeleton of crustaceans. Glucosamine can be used to maintain the health of bone tissue and bone joints, and can improve the homeostasis of endoplasmic reticulum proteins, thereby prolonging the life of cells. Glucosamine is the latest third-generation health-care functional food additive in chitin health food series. It can be used as a low-calorie sweetener, and can also be used as a food additive for anti-cancer, anti-cancer, lowering blood fat, and lowering blood pressure. It can also be used as a Food additives for diabetics. At the same time, the compound can also be used as an important precursor for synthesizing bifidit...

Claims

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Application Information

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IPC IPC(8): C07H1/06C07H5/06A23K20/00
CPCA23K20/00C07H1/06C07H5/06
Inventor 王东阳蔡传康刘朋朋高杰包栋材
Owner SHANDONG YANGCHENG BIOLOGY TECH CO LTD
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