Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for preparing kalii dehydrographolidi succinas freeze-dried powder injection

The technology of freeze-dried powder injection and Chuanhuning is applied in the field of preparation of Chuanhuning freeze-dried powder injection for injection, which can solve problems such as toxic and side effects, and achieve the effects of improving curative effect and safety, enhancing curative effect and good quality stability.

Inactive Publication Date: 2018-11-20
HAINAN GENERAL & KANGLI PHARMA
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Chuanhuning for injection prepared by the current method may still contain impurities that cause toxic and side effects, and these impurities mainly include high-molecular plant protein, products of hydrolysis and oxidation of Chuanhuning, and pigments, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0027] A preparation method of Chuanhuning freeze-dried powder injection for injection according to the present invention mainly comprises the following steps:

[0028] S1. Ingredients: Weigh a predetermined amount of Chuanhuning, sodium bicarbonate and water for injection according to the formula, and the amount of ingredients in the formula can be used to make 1000 tubes of 80 mg Chuanhuning freeze-dried powder for injection. Wherein the dosage of various components is: Chuanhuning is 80g, sodium bicarbonate is 24g, and the total amount of water for injection is 1200ml.

[0029] S2. Dispensing: First, inject 40-50% of the full amount of water for injection into the liquid preparation tank, add Chuanhuning and sodium bicarbonate prepared in step S1 respectively into the liquid preparation tank, stir fully to dissolve them completely, and then add The remaining water for injection is added to the full amount, and the medicinal solution A is obtained at this time.

[0030] S3....

Embodiment 1

[0041] A preparation method of 80 mg Chuanhuning freeze-dried powder for injection, mainly comprising the following steps:

[0042] S1. Ingredients: Weigh a predetermined amount of Chuanhuning, sodium bicarbonate and water for injection according to the formula, wherein the dosage of each component is: Chuanhuning is 80g, sodium bicarbonate is 24g, and the total amount of water for injection is 1200ml. The dosage of ingredients in the formula can be used to make 1000 sticks of Chuanhuning freeze-dried powder for injection.

[0043] S2. Dispensing: First, inject a full amount of 40% water for injection into the liquid preparation tank, add Chuanhuning and sodium bicarbonate prepared in step S1 into the liquid preparation tank respectively, stir fully to dissolve them completely, and then add the remaining Add water for injection to the full amount, and at this time, medicinal solution A is obtained.

[0044] S3. Filtration: including at least two processes of coarse filtration...

Embodiment 2

[0056] The difference between this embodiment and embodiment 1 is:

[0057] S2. Dispensing: First, inject 50% of the total amount of water for injection into the liquid preparation tank, add Chuanhuning and sodium bicarbonate prepared in step S1 into the liquid preparation tank respectively, stir fully to dissolve them completely, and then add the remaining Add water for injection to the full amount, and at this time, medicinal solution A is obtained.

[0058] S31 coarse filtration: adding a predetermined amount of activated carbon to the medicinal solution A obtained in step S3, the amount of activated carbon used is 0.05% (w / v) of the total volume of the configured medicinal solution A, after adding activated carbon, the Liquid A was fully stirred for 30 minutes, and then a filter element with a filter pore diameter of 0.45um was used to filter and decarburize to complete the coarse filtration.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing a kalii dehydrographolidi succinas freeze-dried powder injection and belongs to the field of medicine preparation. The method mainly comprises steps of preparing materials, blending medicines, filtering, storing, pre-freezing, drying, and the like, thereby finally obtaining a finished product of the kalii dehydrographolidi succinas freeze-dried powderinjection. The step of filtering comprises steps of uniformly stirring a medicine liquid A with a preset amount of activated carbon, and further carrying out at least two procedures of rough filtration with a filter element and further fine filtration with a filtering membrane; the step of drying comprises two times of heating treatment on a partition plate respectively. By adopting the method for preparing the kalii dehydrographolidi succinas freeze-dried powder injection, the obtained kalii dehydrographolidi succinas freeze-dried powder injection is stable and reliable in quality.

Description

technical field [0001] The invention relates to a pharmaceutical method, in particular to a preparation method of Chuanhuning freeze-dried powder for injection. Background technique [0002] Chuanhuning for injection is a drug for the immune system. It has a strong antipyretic effect on fever caused by bacterial endotoxin and can promote the disappearance of fever. It can be used to treat viral pneumonia, viral upper respiratory tract infection and other diseases. [0003] At present, Chuanhuning preparation products mainly include Chuanhuning injection and Chuanhuning freeze-dried powder for injection. Chuanhuning injection is unstable and valid for 30.5 days at room temperature. Because Chuanhuning is a diterpenoid lactone compound with a conjugated double bond in the molecule, it has high chemical activity and is prone to hydrolysis and oxidation reactions. To carry out high temperature sterilization, and promote the decomposition reaction. Pure Chuanhuning aqueous solu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/365A61P29/00A61P11/00A61P31/12
CPCA61K9/0019A61K9/19A61K31/365A61P11/00A61P29/00A61P31/12
Inventor 吴玉章杨杰钟海雄林小雪符永红王静
Owner HAINAN GENERAL & KANGLI PHARMA