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Preparation method of effective part of gentiana straminea with inflammation-diminishing and pain-relieving functions and medicine

An anti-inflammatory, analgesic, and effective part technology, which is applied in the field of separation of effective parts of traditional Chinese medicine, to achieve the effect of simple method, easy dissolution, and reasonable excipients

Inactive Publication Date: 2018-11-23
QINGHAI UNIV FOR NATITIES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current development of new drugs with active parts of traditional Chinese medicine, the confirmation methods for active ingredients are generally based on literature reports, and it is rare to extract one type or a mixture of several types of chemical components in a new drug of traditional Chinese medicine for efficacy tests. The one or several types of chemical composition mixture is effective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1) Collect the aboveground parts of Gentiana that are in flowering period from July to September every year and dry them in a cool and ventilated place;

[0026] 2) Grind the dried above-ground part of Gentiana twisted to obtain crushed material, the fineness of the crushed material is 80 mesh, then add water to the crushed material and extract by heat reflux, extract once, filter and constant volume, the extraction temperature is 68°C , the mass ratio of pulverized material to water is 1:12;

[0027] 3) After the filtrate after filtering the extract is adsorbed and separated by D101 macroporous resin, the pH value during the adsorption and separation process is 7, and the filtrate obtained by treating 0.3g of pulverized material per milliliter of D101 macroporous resin, the fraction collected per minute Equivalent to 1 / 10 of the column volume, when the concentration of the sample solution is 0.510mg / mL; then desorb from the macroporous resin to obtain the effective par...

Embodiment 2

[0031] 1) Collect the aboveground parts of Gentiana that are in flowering period from July to September every year and dry them in a cool and ventilated place;

[0032] 2) Grind the dried above-ground part of Gentiana twista to obtain crushed material, the fineness of the crushed material is 80 mesh, then add water to the crushed material and then extract it by heat reflux, extract once, filter to constant volume, and the extraction temperature is 70°C , the mass ratio of pulverized material to water is 1:11;

[0033] 3) After the filtrate after filtering the extract is adsorbed and separated by D101 macroporous resin, the pH value during the adsorption and separation process is 6.9, and the filtrate obtained by treating 0.29g of pulverized material per milliliter of D101 macroporous resin, the fraction collected per minute Equivalent to 1 / 10 of the column volume, when the concentration of the sample solution is 0.510 mg / mL; then desorb from the macroporous resin to obtain the...

Embodiment 3

[0037] 1) Collect the aboveground parts of Gentiana that are in flowering period from July to September every year and dry them in a cool and ventilated place;

[0038]2) Grind the dried above-ground part of Gentiana mahua to obtain crushed material, the fineness of the crushed material is 80 mesh, then add water to the crushed material and extract it by heat reflux, extract once, filter and constant volume, the extraction temperature is 69°C , the mass ratio of pulverized material to water is 1:14;

[0039] 3) After the filtrate after filtering the extract is adsorbed and separated by D101 macroporous resin, the pH value during the adsorption and separation process is 7.2, and the filtrate obtained by treating 0.31g of pulverized material with D101 macroporous resin per milliliter, the fraction collected per minute Equivalent to 1 / 10 of the column volume, when the concentration of the sample solution is 0.510 mg / mL; then desorb from the macroporous resin to obtain the effecti...

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Abstract

The invention relates to a preparation method of an effective part of gentiana straminea with inflammation-diminishing and pain-relieving functions and a medicine, and belongs to the technical field of separation of effective parts of traditional Chinese medicine. The preparation method is characterized by comprising the following preparation steps of collecting the ground part of the gentiana straminea in the flowering stage, putting at the shady and air-ventilating area, and drying; crushing the dried ground part of the gentiana straminea to obtain the crushed material, adding water into thecrushed material, and extracting by a heat reflux method, wherein the extracting temperature is 67 to 72 DEG C, and the mass ratio of the crushed material to the water is 1:(11 to 15); adsorbing andseparating the filtrate after filtering of the extracted solution by macroporous resin, and desorbing from the macroporous resin, so as to obtain the effective part; concentrating the effective part into cream, and mixing with soluble starch and sugar powder, so as to obtain particles. The preparation method has the advantages that the cost is low, and the residue of organic solvent is avoided; the effective part with higher content of effective components is extracted at higher extracting rate, and the prepared particles are uniform and are easy to dissolve.

Description

technical field [0001] The invention discloses a preparation method and medicament of an effective part of Gentiana japonica with anti-inflammatory and analgesic effects, and belongs to the technical field of separation of effective parts of traditional Chinese medicines. Background technique [0002] Gentiana straminea (Gentiana straminea Maxim.) is a traditional and authentic medicinal material, the main medicinal species of Gentiana straminea Maxim. in traditional Chinese medicine, and the main species of "Jieji" Tibetan medicine. Traditional Chinese medicine uses roots as medicine, and is mainly used to treat rheumatoid arthritis, tuberculosis, low-grade fever and night sweats, and icteric hepatitis. However, over-excavation over the years has not only caused serious damage to this resource, but also seriously endangered the fragile ecological environment of the Qinghai-Tibet Plateau. [0003] The effective part of traditional Chinese medicine refers to when the content...

Claims

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Application Information

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IPC IPC(8): A61K36/51A61K9/16A61P29/00
CPCA61K9/1623A61K9/1652A61K36/51A61K2236/15A61K2236/17A61K2236/331A61K2236/55A61P29/00
Inventor 林鹏程刘世珠王志波王敏王怡姚政王泽吴蕾
Owner QINGHAI UNIV FOR NATITIES
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