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Nano-drug carrier Au/MnO2 and preparation method and application thereof

A nano-drug carrier, gold nanorod technology, used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., to achieve the effect of inhibiting recurrence and transformation

Active Publication Date: 2018-11-30
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are few literature and patent reports on MnO 2 Based hybrid materials applied to entrapment of antitumor drugs

Method used

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  • Nano-drug carrier Au/MnO2 and preparation method and application thereof
  • Nano-drug carrier Au/MnO2 and preparation method and application thereof
  • Nano-drug carrier Au/MnO2 and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0044] The preparation of embodiment 1AuNRs

[0045] Dissolve 0.3645g of CTAB in 9.9mL of deionized water to prepare a CTAB solution with a concentration of 1mmol / L. After the CTAB is completely dissolved, add 100uL of HAuCl with a concentration of 25mmol / L to the CTAB solution 4 solution, the color of the solution changed from colorless and transparent to golden yellow, and was stirred in a constant temperature water bath at 28°C for 10 min. 0.6ml of NaBH with a concentration of 0.01mol / L 4 The solution was quickly added to the above mixed solution and stirred for 2 minutes. At this time, the color of the solution quickly changed from golden yellow to tea brown. The preparation of the seed solution was completed. The seed solution was kept in a constant temperature water bath at 28°C in the dark for 2 hours for later use. Add 3.645 g of CTAB to 100 mL of deionized water, stir in a constant temperature water bath at 30°C for 15 min, and add 2 mL of HAuCl with a concentration ...

Embodiment 2

[0047] The preparation of embodiment 2AuNRs

[0048] Dissolve 0.3 g of CTAB in 8.0 mL of deionized water to prepare a CTAB solution. After the CTAB is completely dissolved, add 40 uL of HAuCl with a concentration of 50 mmol / L to the CTAB solution 4 solution, the color of the solution changed from colorless and transparent to golden yellow, and was stirred in a constant temperature water bath at 28°C for 10 min. The 0.48ml concentration is the NaBH of 0.1mol / L 4 The solution was quickly added to the above mixed solution and stirred for 2 minutes. At this time, the color of the solution quickly changed from golden yellow to tea brown. The preparation of the seed solution was completed. The seed solution was kept in a constant temperature water bath at 28°C in the dark for 2 hours for later use. Add 3.0 g of CTAB to 90 mL of deionized water, stir in a constant temperature water bath at 30 °C for 15 min, and add 1 mL of HAuCl with a concentration of 50 mmol / L after the CTAB is co...

Embodiment 3

[0049] Example 3 Preparation of AuNRs

[0050] Dissolve 0.4 g of CTAB in 6.0 mL of deionized water to prepare a CTAB solution. After the CTAB is completely dissolved, add 70 uL of HAuCl with a concentration of 40 mmol / L to the CTAB solution 4 solution, the color of the solution changed from colorless and transparent to golden yellow, and was stirred in a constant temperature water bath at 28°C for 10 min. 2ml of NaBH with a concentration of 0.03mol / L 4 The solution was quickly added to the above mixed solution and stirred for 2 minutes. At this time, the color of the solution quickly changed from golden yellow to tea brown. The preparation of the seed solution was completed. The seed solution was kept in a constant temperature water bath at 28°C in the dark for 2 hours for later use. Add 4 g of CTAB to 95 mL of deionized water, stir in a constant temperature water bath at 30°C for 15 min, and add 20 mL of HAuCl with a concentration of 2.5 mmol / L after the CTAB is completely d...

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Abstract

The invention discloses a nano-drug carrier Au / MnO2. The nano-drug carrier is a core-shell structure with the gold nanorod AuNRs as the core and mesoporous manganese dioxide MnO2 as the shell. A preparation method comprises the following steps: firstly preparing AuNRs by a seed growing method, and then coating the surface of AuNRs with MnO2 having the mesoporous structure by the utilization of a reaction between potassium permanganate and anhydrous ethanol in an alkaline or neutral environment. Light and heat stability of AuNRs is raised, and the drug loading purpose is also achieved. By combining MnO2 and AuNRs, the synergistic treatment effect can be effectively enhanced. The original tumor is further killed. Through the reaction with GSH, H<+> and H2O2 existing in the tumor microenvironment for decomposition into water and oxygen, tumor hypoxia is alleviated and the tumor microenvironment is improved, growth of distal tumor is effectively inhibited. It shows that a MnO2-based hybridmaterial has a huge application potential in the field of tumor treatment.

Description

technical field [0001] The invention belongs to drug carrier technology, in particular to a nano drug carrier Au / MnO 2 And its preparation method and application. Background technique [0002] According to data released by the World Health Organization (WHO) in 2017, the total number of cancer deaths in countries around the world is as high as 8.8 million each year, accounting for about 1 / 6 of the total annual death toll, and there are as many as 14 million new cancer cases each year. It is estimated that by 2030 In 2009, the annual new cases will reach 21 million, and cancer is still one of the major diseases that seriously endanger human life, health and life expectancy. Whether it is the number of deaths or new cases, China ranks first in the world. [0003] Gold nanorods (AuNRs) have tunable surface plasmon resonance (SPR) properties and good biocompatibility in the visible or near-infrared (NIR) region, and can become localized through the photothermal conversion effe...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K31/704A61K41/00A61P35/00
CPCA61K9/5115A61K31/704A61K41/0052A61P35/00A61K2300/00
Inventor 吉远辉张政
Owner SOUTHEAST UNIV
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