Application of tyrosol in preparing drug for treating diabetic complication diabetic foot

A technology for diabetic foot and tyrosol, applied in the field of medicine, can solve problems such as low sensitivity, and achieve the effect of promoting the formation of vascular lumen in the lower extremities and achieving excellent therapeutic effect.

Inactive Publication Date: 2018-12-11
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are also research reports that the decrease of VEGFR2 on the cell surface under high glucose conditions prevents the signal transduction of the VEGF-VEGFR2 pathway, inhibits the vascular remodeling process such as the proliferation of ...

Method used

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  • Application of tyrosol in preparing drug for treating diabetic complication diabetic foot
  • Application of tyrosol in preparing drug for treating diabetic complication diabetic foot
  • Application of tyrosol in preparing drug for treating diabetic complication diabetic foot

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Experimental program
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Embodiment

[0065] 1. Effect of tyrosol in high glucose system on angiogenesis factors of skeletal muscle cells

[0066] C2C12, HUVECs and MOVAS cell lines were purchased from American Type Culture Collection (ATCC).

[0067] All cells were cultured in Dulbecco's modified Eagle medium basic (Gibco, Life Technologies, Grand Island, NY), and 10% fetal calf serum (Biological Industries, Israel) was added to the medium.

[0068] For the high glucose experiment, the cells were cultured with a medium containing 25 mM glucose (high glucose medium) for 24 h, and as a control, the cells were cultured in a medium with 5.5 mM glucose (low glucose medium).

[0069] After the skeletal muscle cells C2C12 were treated with tyrosol, the detection of the protein expression levels of PDGF-BB and VEGF-A proteins was carried out, including the following steps:

[0070] 1) Inoculate skeletal muscle cells C2C12 into a 6cm cell culture plate at an amount of 150,000 / well;

[0071] 2) After low sugar (5.5mM), h...

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Abstract

The invention discloses an application of tyrosol in preparing a drug for treating a diabetic complication diabetic foot and an accelerant for expressing and secreting an angiogenic factor. The effective component of the accelerant is tyrosol and the accelerant promotes expression and secretion of the angiogenic factor of a skeletal muscle cell. The angiogenic factor comprises PDG-BB and VEGF-A. The accelerant promotes expression and secretion of the angiogenic factor of the skeletal muscle cell in a high glucose condition. An accelerant for proliferating and migrating a skeletal muscle cell C2C12 is characterized in that the effective component of the accelerant is tyrosol. The accelerant promotes proliferation and migration of the skeletal muscle cell C2C12 in the high glucose condition.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of tyrosol in the preparation of medicines for treating diabetic complications and diabetic foot. Background technique [0002] Diabetic foot is one of the most common and serious complications of diabetes. Unsatisfactory blood sugar control leads to peripheral vascular disease of the lower limbs, which leads to insufficient blood supply of the lower limbs and hypoxia of the tissue cells of the lower limbs. In addition, the ability of tissue repair and wound healing is significantly reduced under high glucose conditions. In severe cases, tissue gangrene and tissue loss (tissue loss) or even death; clinically severe patients often require amputation. [0003] The ideal treatment method for Diabetic Foot is to improve the blood supply status. Currently, stents, bypass grafts, and balloon dilatation are used to treat vascular lesions. However, diabetic patients have a high...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P3/10A61P9/00
CPCA61K31/05A61P3/10A61P9/00
Inventor 江启慧吴寿荣张建琪徐爱枚
Owner CHONGQING UNIV
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