Preparation method of chlorhexidine-iodine nanometer complex

A nano-complex and chlorhexidine technology, which is applied to the active ingredients of iodine compounds, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of long-lasting effect, inability to achieve tight combination, and fast sterilization speed , to achieve the effect of controllable size, not easy to coalesce, and improve the sterilization effect

Inactive Publication Date: 2018-12-11
SHANGHAI LIKANG DISINFECTION HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The most commonly used method at present is the direct precipitation method, and it is impossible to prepare preparations with broad-spectrum sterilization, fast sterilization speed, long-lasting effect and low irritation
Such as the preparation of chlorhexidine iodine complex mentioned in the preparation of chlorhexidine iodine solution and the preliminary stability study of the 8th period of volume 31 in August 2012 of Medical Herald, the iodine aqueous solution and the chlorhexidine acetate aqueous solution are mixed fully Stirring, static filtration to obtain precipitate, vacuum drying to obtain chlorhexidine-iodine complex, the resulting chlorhexidine-iodine complex particle size is large, tight combination cannot be achieved between chlorhexidine and iodine, and poor affinity with skin

Method used

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  • Preparation method of chlorhexidine-iodine nanometer complex
  • Preparation method of chlorhexidine-iodine nanometer complex

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Embodiment 1

[0034] The preparation technology of described chlorhexidine iodine nano-complex is as follows:

[0035] (1) Take iodine 15g, potassium iodide 9g, add purified water 51g, stir and dissolve, make 20% iodine solution;

[0036] (2) Take chlorhexidine acetate 22g, add purified water 88g, stir and dissolve, make 20% chlorhexidine solution;

[0037] (3) Weigh 76g of Tween-80 and 54g of n-hexanol, add to 180g of isooctane, stir and mix to make an organic phase;

[0038] (4) the organic phase is divided into two parts on average, one part adds 20% iodine solution, stirs and emulsifies, makes iodine microemulsion; Adds 20% chlorhexidine solution in another part, stirs and emulsifies, makes chlorhexidine microemulsion ;

[0039] (5) Add the chlorhexidine microemulsion in the iodine microemulsion under the condition of vigorous stirring, continue to stir for 50min, after separating with a 40000r.min centrifuge for 10min, filter, rinse with acetone first, then rinse the precipitate with...

Embodiment 2

[0043] The preparation technology of described chlorhexidine iodine nano-complex is as follows:

[0044] (1) Take iodine 30g, potassium iodide 18g, add purified water 102g, stir and dissolve, make 20% iodine solution;

[0045] (2) Take by weighing 20% ​​chlorhexidine gluconate solution 75g;

[0046] (3) Weigh 124g of polyoxyethylene lauryl ether and 60g of n-butanol, add them to 220g of cyclohexane, stir and mix, and make an organic phase;

[0047] (4) the organic phase is divided into two parts on average, one part adds 20% iodine solution, stirs and emulsifies, makes iodine microemulsion; Adds 20% chlorhexidine solution in another part, stirs and emulsifies, makes chlorhexidine microemulsion ;

[0048] (5) Add the chlorhexidine microemulsion in the iodine microemulsion under the condition of vigorous stirring, continue to stir for 50min, after separating with a 40000r.min centrifuge for 10min, filter, rinse with acetone first, then rinse the precipitate with purified water...

Embodiment 3

[0052] The preparation technology of described chlorhexidine iodine nano-complex is as follows:

[0053] (1) Take iodine 45g, potassium iodide 27g, add purified water 153g, stir and dissolve, make 20% iodine solution;

[0054] (2) Take chlorhexidine acetate 12g, add purified water 48g, stir and dissolve, make 20% chlorhexidine solution;

[0055] (3) Weigh 140g of poloxamer 407 and 86g of n-pentanol, add it to 350g of isooctane, stir and mix to make an organic phase;

[0056] (4) the organic phase is divided into two parts on average, one part adds 20% iodine solution, stirs and emulsifies, makes iodine microemulsion; Adds 20% chlorhexidine solution in another part, stirs and emulsifies, makes chlorhexidine microemulsion ;

[0057] (5) Add the chlorhexidine microemulsion in the iodine microemulsion under the condition of vigorous stirring, continue to stir for 50min, after separating with a 40000r.min centrifuge for 10min, filter, rinse with acetone first, then rinse the prec...

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Abstract

The invention relates to a preparation method of a chlorhexidine-iodine nanometer complex. The prepared chlorhexidine-iodine nanometer complex is prepared from the following components in percentage by weight: 5-35 percent of chlorhexidine, 3-30 percent of iodine, 2-18 percent of potassium iodide, 10-30 percent of surfactant, 5-15 percent of cosurfactant, 25-45 percent of organic solvent and 4-30percent of purified water. The chlorhexidine-iodine nanometer complex prepared by utilizing the preparation method is relatively narrow in particle size distribution and liable to control; nanoparticles with uniform particle size can be relatively easily obtained; and by selecting different surface active molecules to perform wrapping and modification on particles, so that the particles are difficult to perform coalescence, and good stability is achieved. Compared with a product by adding an ordinary chlorhexidine-iodine complex in skin and mucosa disinfection hygienic products, by utilizing the chlorhexidine-iodine nanometer complex, a product is good in stability, small in irritation, strong in disinfection effect and safe and convenient to use and has the broad-spectrum antibacterial performance.

Description

technical field [0001] The invention belongs to the field of medical disinfection, and in particular relates to the preparation of chlorhexidine-iodine nano-complexes by adopting a microemulsion method. Background technique [0002] The preparation of nanoparticles by microemulsion method is a simple and intelligent new method, which is a research hotspot at present. It uses two immiscible solvents to form a thermodynamically stable, Isotropic, transparent or translucent uniform liquid dispersion system (diameter of dispersed phase is about 1-100nm), that is, microemulsion, and then the solid phase is precipitated from the microemulsion to prepare nanopowder with a certain particle size. Microemulsions generally consist of surfactants, co-surfactants, solvents and water. In this system, two immiscible continuous media are divided into tiny spaces by surfactant amphiphile molecules to form microreactors, the size of which can be controlled in the nanoscale range, and the rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K9/107A61P31/02A61P31/04A61P31/10A61K31/155
CPCA61K9/0014A61K9/1075A61K31/155A61K33/18A61P31/02A61P31/04A61P31/10A61K2300/00
Inventor 许芸张万国邹贤信卞雪莲
Owner SHANGHAI LIKANG DISINFECTION HIGH TECH
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