The present invention discloses an esomeprazole sodium 1,2-propylene glycol solvate and a preparation process thereof, wherein X-ray powder diffraction spectrogram has characteristic diffraction peaks when a diffraction angle 2theta is 5.84+ / -0.1, 10.88+ / -0.1, 11.78+ / -0.1, 15.58+ / -0.1, 20.36+ / -0.1, 20.98+ / -0.1,22.54+ / -0.1, 22.90+ / -0.1, 23.98+ / -0.1, 24.42+ / -0.1, 24.68+ / -0.1, 25.32+ / -0.1, 26.36+ / -0.1, 27.82+ / -0.1, 29.76+ / -0.1, 31.74+ / -0.1, and 32.40+ / -0.1. The starting material esomeprazole sodium is added to the 1,2-propylene glycol, the mixture is stirred at a temperature of 10 to 60 DEG C for 2 to 9 hours, and through filtering and drying, the esomeprazole sodium 1,2-propylene glycol solvate is obtained. The preparation process according to the present invention is simple, achieves a high yield, and obtains safe and nontoxic solvent. The obtained product esomeprazole sodium 1,2-propylene glycol solvate has a greater crystalline granularity, fails to be aggregated simply, and achieves a good stability.