Flavone acetylsalicylate solid dispersion and preparation method thereof

A technology of solid dispersion and acetaloflavone, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as incomplete absorption, increase the surface area, and prevent aggregation and aggregation, enhance the solubility of the effect

Inactive Publication Date: 2009-11-11
SHANGHAI UNIV OF T C M +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the situation of stripping and incomplete absorption caused by the water insolubility of flavone, and propose a solid dispersion of flavone, so that the insoluble flavone is highly dispersed in a strong hydrophilic carrier , not only can maintain a highly dispersed state of poorly soluble drugs, but also make the drugs have good wettability, so as to make preparations that can improve drug solubility, accelerate drug dissolution rate, and improve bioavailability

Method used

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  • Flavone acetylsalicylate solid dispersion and preparation method thereof
  • Flavone acetylsalicylate solid dispersion and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 (preparation of flavone solid dispersion)

[0018] Weigh 3 grams of acetaloflavone and 12 grams of poloxamer 188, dissolve them completely in 200ml of 80% ethanol, stir for 30 minutes, evaporate in a constant temperature water bath at 70°C until there is no alcohol smell, pour it out, and dry it in a water bath until it becomes viscous Semi-solid, frozen and solidified at -18~-22°C for 12 hours, taken out, dried overnight at 40°C, crushed to obtain aceflavone solid dispersion.

Embodiment 2

[0019] Embodiment 2 (preparation of dispersion capsule)

[0020] Components and their contents: 200 mg of flavone solid dispersion prepared in Example 1, 30 mg of dextrin, an appropriate amount of 10% starch slurry, and an appropriate amount of magnesium stearate.

[0021] Preparation method: Weigh acetaloflavone solid dispersion and dextrin, pass through a 80-mesh sieve, mix evenly, add 10% starch slurry, make soft material, pass through a 22-mesh sieve to granulate, dry at 40°C for 30 minutes, 22-30 mesh Sieve for granulation, add appropriate amount of magnesium stearate, and fill to obtain capsules.

Embodiment 3

[0022] Embodiment 3 (preparation of flavone solid dispersion)

[0023] Weigh 3 grams of acetaloflavone and 8 grams of polyethylene glycol-4000; heat the polyethylene glycol-4000 to a molten state, add the above-mentioned acetaloflavone, stir well (1 hour), and freeze at -18~-22°C After curing for 12 hours, take it out, dry at 40°C overnight, and pulverize to obtain the aceflavone solid dispersion.

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PUM

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Abstract

The invention discloses flavone acetylsalicylate solid dispersion. The dispersion is prepared by preparing the flavone acetylsalicylate and a hydrophilic carrier, wherein the weight ratio of the flavone acetylsalicylate and the hydrophilic carrier is between (1:1) and (1:10). The insoluble flavone acetylsalicylate is highly dispersed in the strong hydrophilic carrier, so the invention can not only maintain the highly-dispersed state of insoluble drugs, and but also enables the drugs to have good wettability to be produced to be the preparation capable of improving drug solubility, quickening drug dissolution velocity and improving bioavailability. In addition, the invention also discloses a method for preparing the flavone acetylsalicylate solid dispersion.

Description

technical field [0001] The invention relates to a flavone solid dispersion; in addition, the invention also relates to a preparation method of the dispersion. Background technique [0002] Total flavones of hippophae rhamnoides (THF) is the total flavones extracted from the fruit of Hippophae rhamnoides. Among them, the identified flavonoids mainly include quercetin and its glycosides, isorhamnetin and its glycosides. Acetaloflavone can directly scavenge superoxide free radicals, treat hypoxic heart disease, resist arrhythmia, relieve angina pectoris, reduce high blood pressure, reduce blood fat and blood viscosity, soften blood vessels; it can also improve the body's immune function and enhance the body's resistance to disease ability, has a certain anti-cancer effect. [0003] Solid dispersion refers to the highly dispersed drug in the state of molecules, colloids or ultrafine particles in the inert carrier, forming a dispersion system in the form of solid, also known as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K47/34A61K47/32A61K47/18A61K47/40A61P9/10A61P9/12A61P3/06A61P37/04A61P9/06A61P39/06A61K47/10
Inventor 谢燕王青春袁秀荣蔡贞贞李国文丁宁
Owner SHANGHAI UNIV OF T C M
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