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Preparation method of a zinc/magnesium composite MOF coating mediated antibacterial/anti-inflammatory/bone-promoting titanium-based implant material

An implant material and bone-promoting technology, applied in coatings, metal material coating processes, prostheses, etc., can solve problems such as poor stability, and achieve the effects of promoting bone-promoting properties, reducing normal cytotoxicity, and improving coating stability.

Active Publication Date: 2020-09-22
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In addition, the research conclusion also shows that common MOFs materials have poor stability in aqueous solution, and water molecules can induce rapid degradation of materials through coordination bond interference, and the degradation rate is more significant under acidic conditions.

Method used

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  • Preparation method of a zinc/magnesium composite MOF coating mediated antibacterial/anti-inflammatory/bone-promoting titanium-based implant material
  • Preparation method of a zinc/magnesium composite MOF coating mediated antibacterial/anti-inflammatory/bone-promoting titanium-based implant material
  • Preparation method of a zinc/magnesium composite MOF coating mediated antibacterial/anti-inflammatory/bone-promoting titanium-based implant material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The preparation method of AT-Mg implant material is characterized in that, comprises the following steps:

[0066] 1) Construction of nanosheet structured titanium-based surface by alkaline hot corrosion method;

[0067] 1.1) pretreating the titanium sheet;

[0068] 1.1.1) Use sandpaper to polish the titanium sheet (Ti); if figure 1 Shown in A, be the surface scanning electron microscope (SEM) figure of the titanium sheet after grinding and polishing;

[0069] The mesh number of described sandpaper is 400, 1000 and 2000 mesh;

[0070] 1.1.2) Ultrasonic cleaning the polished titanium sheet with ethanol, acetone and deionized water in sequence;

[0071] In the ultrasonic cleaning process: the time is 10 minutes, and the frequency is 40KHz.

[0072] 1.2) immerse the pretreated titanium sheet obtained in step 1.1) into a sodium hydroxide solution, and then corrode at different temperatures;

[0073] The concentration of the sodium hydroxide solution is 5M;

[0074] Th...

Embodiment 2

[0098] The preparation method of AT-Mg / Zn1 implant material is characterized in that, comprises the following steps:

[0099] 1) Construction of nanosheet structured titanium-based surface by alkaline hot corrosion method;

[0100] 1.1) pretreating the titanium sheet;

[0101] 1.1.1) Use sandpaper to polish the titanium sheet (Ti); if figure 1 Shown in A, be the surface scanning electron microscope (SEM) figure of the titanium sheet after grinding and polishing;

[0102] The mesh number of described sandpaper is 400, 1000 and 2000 mesh;

[0103] 1.1.2) Ultrasonic cleaning the polished titanium sheet with ethanol, acetone and deionized water in sequence;

[0104] In the ultrasonic cleaning process: the time is 10 minutes, and the frequency is 40KHz.

[0105] 1.2) immerse the pretreated titanium sheet obtained in step 1.1) into a sodium hydroxide solution, and then corrode at different temperatures;

[0106] The concentration of the sodium hydroxide solution is 5M;

[0107...

Embodiment 3

[0132] The preparation method of AT-Mg / Zn2 implant material is characterized in that, comprises the following steps:

[0133] 1) Construction of nanosheet structured titanium-based surface by alkaline hot corrosion method;

[0134] 1.1) pretreating the titanium sheet;

[0135] 1.1.1) Use sandpaper to polish the titanium sheet (Ti); if figure 1 Shown in A, be the surface scanning electron microscope (SEM) figure of the titanium sheet after grinding and polishing;

[0136] The mesh number of described sandpaper is 400, 1000 and 2000 mesh;

[0137] 1.1.2) Ultrasonic cleaning the polished titanium sheet with ethanol, acetone and deionized water in sequence;

[0138] In the ultrasonic cleaning process: the time is 10 minutes, and the frequency is 40KHz.

[0139] 1.2) immerse the pretreated titanium sheet obtained in step 1.1) into a sodium hydroxide solution, and then corrode at different temperatures;

[0140] The concentration of the sodium hydroxide solution is 5M;

[0141...

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Abstract

The invention discloses a method for preparing a zinc / magnesium composite MOF coating mediated antibacterial / anti-inflammation / bone shape promotion titanium-based implant material. The method comprises the following steps: firstly, forming a titanium dioxide nanosheet structure on the surface of a titanium material through alkali thermal treatment; putting alkali thermal treatment samples into a diluted hydrochloric acid solution and a magnesium nitrate solution in sequence so as to obtain magnesium titanate nanosheet coatings; finally, putting the samples into a high-pressure reaction kettlewith 2,5-dyhydroxy terephthalic acid, zinc nitrate and magnesium nitrate of different proportions, and carrying out a reaction for 24 hours at 125 DEG C. The obtained series of zinc / magnesium composite MOF coating modified samples have antibacterial, anti-inflammation and bone shape promotion properties of different degrees, and an AT / Mg / Zn3 sample has the most excellent comprehensive properties,and has good clinical application prospects.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing a zinc / magnesium composite MOF coating-mediated antibacterial / anti-inflammatory / bone-promoting titanium-based implant material. Background technique [0002] As a common implant material in orthopedics and dentistry, titanium has been proven to have superior mechanical properties and biocompatibility, but the biological inertia of the material itself will significantly hinder the effective integration between the implant and the surrounding bone tissue . Studies have shown that there is mostly "mechanical condensation" between titanium and bone tissue, and the loosening or displacement of the implant is very easy to occur. The above adverse phenomena are more common when bacterial infection occurs. [0003] With the development of surgical aseptic techniques, the rate of bacterial infection in the early postoperative period has been significantly reduc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/28A61L27/30A61L27/50A61L27/54C23C22/05C23C18/02
CPCA61L27/06A61L27/28A61L27/306A61L27/50A61L27/54A61L2300/404A61L2300/41A61L2300/412A61L2300/606A61L2420/02A61L2420/04A61L2430/02C23C18/02C23C22/05
Inventor 蔡开勇沈新坤张杨杨
Owner CHONGQING UNIV