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Preparation method of palladium carbon catalyst for meropenem

A technology of palladium-carbon catalyst and meropenem, which is applied in the field of preparation of palladium-carbon catalyst for meropenem, can solve the problems of environmental pollution, low utilization rate of palladium with active metal palladium crystallite content, etc. The effect of small distribution depth

Active Publication Date: 2021-03-23
CHONGQING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a method for preparing a palladium-carbon catalyst for meropenem, so as to solve the technical problems in the prior art such as the microcrystalline content of the active metal palladium, the low utilization rate of palladium, and environmental pollution.

Method used

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  • Preparation method of palladium carbon catalyst for meropenem
  • Preparation method of palladium carbon catalyst for meropenem

Examples

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Embodiment 1

[0034] 1) Weigh 100g of 767-type activated carbon for needles, add 800ml of water, add 66ml of 65% concentrated nitric acid, heat up to 90-95°C and stir for 3 hours, cool down to room temperature, filter, wash with purified water until neutral, and dry at 105°C for 3 hours hours, the activated charcoal is obtained for subsequent use.

[0035] 2) Weigh 12.5g of aspartic acid and 9g of sodium hydroxide, add them to 800ml of water, fully stir to dissolve, then add 100g of activated carbon obtained in step 1), then add 28g of concentrated hydrochloric acid, adjust the pH to 2-5 In between, filter and wash with purified water until neutral to obtain activated carbon carrier.

[0036] 3) Dissolve 14.7 g of concentrated hydrochloric acid and 6.4 g of 30% hydrogen peroxide in 1000 ml of water, then add 8.35 g of palladium chloride, stir and dissolve to obtain a palladium salt impregnation solution.

[0037] 4) Add the activated carbon carrier prepared in step 2) to the palladium salt...

Embodiment 2

[0040] 1) Weigh 100g of 767-type activated carbon for needles, add 800ml of water, add 66ml of 65% concentrated nitric acid, heat up to 90-95°C and stir for 3 hours, cool down to room temperature, filter, wash with purified water until neutral, and dry at 105°C for 3 hours hours, the activated charcoal is obtained for subsequent use.

[0041] 2) Weigh 8.3g of alanine and 5.6g of sodium hydroxide, add them into 800ml of water, fully stir and dissolve, then add 100g of activated carbon obtained in step 1), then add 17.5g of concentrated hydrochloric acid, adjust the pH to 2~ 5, filtered, washed with purified water until neutral, and activated carbon carrier was obtained.

[0042] 3) Dissolve 14.7 g of concentrated hydrochloric acid and 21 g of 20% sodium hypochlorite in 1000 ml of water, then add 8.35 g of palladium chloride, stir and dissolve to obtain a palladium salt impregnation solution.

[0043] 4) Add the activated carbon carrier prepared in step 2) to the palladium salt...

Embodiment 3

[0046] 1) Weigh 100g of 767-type activated carbon for needles, add 800ml of water, add 66ml of 65% concentrated nitric acid, heat up to 90-95°C and stir for 3 hours, cool down to room temperature, filter, wash with purified water until neutral, and dry at 105°C for 3 hours hours, the activated charcoal is obtained for subsequent use.

[0047] 2) Weigh 7g of glycine and 9g of sodium hydroxide, add them to 800ml of water, fully stir to dissolve, then add 100g of activated carbon obtained in step 1), then add 28g of concentrated hydrochloric acid, adjust the pH to between 2 and 5, and filter , washed with purified water to neutral to obtain activated carbon carrier.

[0048] 3) Dissolve 14.7 g of concentrated hydrochloric acid and 6.4 g of 30% hydrogen peroxide in 1000 ml of water, then add 10.8 g of palladium nitrate, stir and dissolve to obtain a palladium salt impregnation solution.

[0049] 4) Add the activated carbon carrier prepared in step 2) to the palladium salt impregn...

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Abstract

The invention discloses a preparation method of a palladium-carbon catalyst for meropenem. The preparation method specifically comprises the following steps: enabling a filler to be dissolved in waterin an alkaline condition, adding activated active carbon, enabling the filler to immerge internal gaps of the active carbon along with solution, and adjusting a pH to 2-5 by using acid, separating out the filler and occupying the internal gaps of the active carbon, adding palladium salt impregnation liquid, adjusting the pH to 9-10 by using alkali, warming to 90-95 DEG C, heat-preserving for 1-2hours, finally performing a reduction reaction, aging, filtering and washing to be neutral by purified water, preparing the palladium-carbon catalyst. The prepared palladium-carbon catalyst is high inmicrocrystal content, most of palladium is mainly distributed on the surface of the active carbon, and activity, selectivity and stability of the palladium-carbon catalyst are effectively improved.

Description

technical field [0001] The invention belongs to the field of chemical catalyst preparation, and more specifically relates to a method for preparing a palladium-carbon catalyst for meropenem. Background technique [0002] Meropenem is the second-generation carbapenem antibiotic launched by Sumitomo Corporation of Japan in 1994 after imipenem. It is 2-6 times more resistant to Gram-positive bacteria and anaerobic bacteria than imipenem. The stability to renal hydrogenase is 4 times higher than that of amipenem, and it is resistant to the kidney and can be used alone. It has excellent characteristics in terms of antibacterial effect, antibacterial activity, pharmacokinetics, and indications. As the first second-generation carbapenem antibiotic, it has changed the history that carbapenem antibiotics cannot be used alone, and is a new milestone in the history of antibiotic development. [0003] During the chemical synthesis of meropenem, the intermediate MAP and the side chain a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J23/44
CPCB01J23/44
Inventor 沟引宁
Owner CHONGQING UNIV OF TECH
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