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Separating extracting method of feed-level niacin

An extraction method and feed-grade technology are applied in the field of separation and extraction of feed-grade niacin, which can solve the problems of difficulty in niacin, greater environmental harm, and high production costs, and achieve the advantages of protecting the environment, improving the purity rate, and saving production costs. Effect

Inactive Publication Date: 2018-12-21
张刘兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main methods of current industrial production of nicotinic acid include: liquid-phase oxidation and gas-phase oxidation. The gas-phase oxidation will produce a large amount of sewage and waste gas, the production cost is very high, and the harm to the environment is relatively large. Difficult to deal with; in order to meet the market demand for hydrochloric acid, develop a new method for the synthesis of nicotinic acid that is more efficient and environmentally friendly. For this reason, the present invention proposes a separation and extraction method for feed-grade nicotinic acid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A method for separating and extracting feed grade niacin, the specific steps of the method are as follows:

[0020] (1) Select the immobilized cells of Bacillus subtilis as a catalyst, and use 3-cyanopyridine with a concentration of 4g / L as a substrate to carry out biotransformation to prepare a transformation liquid containing nicotinic acid, and then uniformly heat the transformation liquid to 80°C, centrifuged at 700r / min for 20min, the centrifugal transformation liquid;

[0021] (2) Gradually drop an acid solution into the centrifuged transformation solution for precipitation, adjust the pH of the transformation solution to 3.7, centrifuge at a speed of 700r / min for 5 to 6 minutes, and use microfiltration to remove the particulate matter in the transformation solution. The cake is dried to obtain crystals;

[0022] (3) After adding 10 times of deionized water to the crystal for dissolving, add 0.3% gac powder of the total solution quality, adopt microfiltration, ul...

Embodiment 2

[0027] A method for separating and extracting feed grade niacin, the specific steps of the method are as follows:

[0028] (1) Select the immobilized cells of Bacillus subtilis as a catalyst, and use 3-cyanopyridine with a concentration of 5 g / L as a substrate to carry out biotransformation to prepare a transformation solution containing nicotinic acid, and then uniformly heat the transformation solution to 75° C., centrifuged at 600r / min for 25min, the centrifugal transformation liquid;

[0029] (2) Gradually dropwise add acid solution to the centrifuged transformation solution for precipitation, adjust the pH of the transformation solution to 3.8, centrifuge at a speed of 700r / min for 5 to 6 minutes, use microfiltration to remove particulate matter in the transformation solution, and filter the obtained The cake is dried to obtain crystals;

[0030] (3) After dissolving the above-mentioned crystals in 12 times of deionized water, add 0.4% gac powder of the total solution qu...

Embodiment 3

[0035] A method for separating and extracting feed grade niacin, the specific steps of the method are as follows:

[0036] (1) Select the immobilized cells of Bacillus subtilis as a catalyst, and use 3-cyanopyridine with a concentration of 6 g / L as a substrate to carry out biotransformation to prepare a transformation liquid containing nicotinic acid, and then uniformly heat the transformation liquid to 76 ° C, centrifuged at 650r / min for 30min, the centrifugal transformation liquid;

[0037] (2) Gradually drop an acid solution into the centrifuged transformation solution for precipitation, adjust the pH of the transformation solution to 4, centrifuge at a speed of 600r / min for 5 to 6 minutes, use microfiltration to remove particulate matter in the transformation solution, and filter the obtained The cake is dried to obtain crystals;

[0038] (3) After adding 15 times of deionized water to the crystal for dissolving, add 0.5% gac powder of the total solution quality, adopt mi...

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Abstract

The invention discloses a separating extracting method of feed-level niacin, and relates to the field of biochemical engineering. The method specifically comprises the following steps: selecting bacillus subtilis immobilized cells as a catalyst; treating 3-cyanopyridine as a substrate; performing biotransformation to prepare niacin-containing transformation liquid; uniformly heating the transformation liquid; centrifuging; gradually dropwise adding an acid solution to the centrifuged transformation liquid to precipitate; regulating the pH of the transformation liquid; centrifuging; performingmicrofiltration; adding the obtained crystal to deionized water to dissolve; then adding activated carbon powder; performing microfiltration, ultrafiltration and nanofiltration three-stage membrane separating method to remove soluble impure protein, pigment and other impurities; and then drying to obtain the niacin product. The method for separating and extracting niacin is stable to catalyze, high in speed, and high in yield; in addition, the pollution is reduced; exhaust is avoided; the production cost is reduced; the environment is protected; the purity of the niacin is increased and is upto 99.99%; and the method has a wide application prospect in massive production of the niacin.

Description

technical field [0001] The invention relates to the field of biochemical industry, in particular to a method for separating and extracting feed-grade niacin. Background technique [0002] Nicotinic acid, also known as vitamin B3, is converted into nicotinamide in the body. Niacinamide is a component of coenzyme I and coenzyme II, and participates in lipid metabolism in the body, the oxidation process of tissue respiration and the process of anaerobic decomposition of carbohydrates. Niacin promotes the health of the digestive system, maintains the health of the nervous system and the normal functioning of the brain, and it is prone to allergies and brain damage when it is deficient. The main methods of current industrial production of nicotinic acid include: liquid-phase oxidation and gas-phase oxidation. The gas-phase oxidation will produce a large amount of sewage and waste gas, the production cost is very high, and the harm to the environment is relatively large. Difficul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P17/12C07D213/80C07D213/803
CPCC07D213/80C07D213/803C12P17/12
Inventor 张刘兵
Owner 张刘兵
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