Multifunctional drug carrier, and preparation method and application thereof
A drug and carrier technology, applied in the field of materials science, can solve the problem of limited cancer effect and achieve good photothermal effect
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Embodiment 1
[0033] The drug carrier provided in this example comprises a metal organic framework ZIF-90 outer layer, a polydopamine middle layer and Fe 3 o 4 Granular core. The preparation method of the drug carrier comprises the following steps:
[0034] (1) 0.71g ferric chloride hexahydrate (FeCl 3 ·6H 2 O), 1.54g sodium citrate (C 6 h 5 Na 3 o 7 ), 0.63g urea (CH 4 N 2 O), 0.52g of polyacrylamide (PAM) was added to 70mL of deionized water and ultrasonically dissolved until it was completely dissolved to obtain a clear solution; then, the clear solution was transferred to a 100mL hydrothermal kettle, and after hydrothermal treatment at 180°C for 10 hours at room temperature Cooling; centrifuge at 8000rpm to collect the black precipitate, wash the black precipitate with deionized water, and dry it in vacuum at 60°C to obtain Fe 3 o 4 particles.
[0035] (2) 68mg Fe 3 o 4 Add the particles into 200mL of Tris buffer solution with pH=8.5, and disperse them evenly under ultraso...
Embodiment 2
[0040] Get the Fe that 30mg embodiment 1 prepares 3 o 4@PDA@ZIF-90 particles were dispersed in 12mL of doxorubicin (DOX) drug in PBS buffer solution (DOX concentration 0.5mg / mL), the above mixture was shaken at room temperature for 24 hours in a light-proof shaker, then centrifuged, PBS buffer Washed several times with liquid solution, and finally freeze-dried to obtain Fe loaded with DOX drug 3 o 4 @PDA @ZIF-90-DOX particles.
[0041] figure 2 For the Fe prepared in Example 1 and Example 2 3 o 4 , Fe 3 o 4 @PDA、Fe 3 o 4 @PDA @ZIF-90 and Fe 3 o 4 The thermogravimetric curve of @PDA@ZIF-90-DOX particles. The concentration of DOX drug on Fe was determined by thermogravimetric analysis. 3 o 4 The loading on @PDA@ZIF-90 particles is about 15%, which has a higher loading of anticancer drug DOX.
[0042] image 3 Fe prepared for Example 2 3 o 4 DOX release curves of @PDA@ZIF-90-DOX particles at pH 7.4, pH 6.0 and pH 4.5, and temperature 37°C.
[0043] The Fe that...
Embodiment 3
[0046] Figure 4 For the Fe prepared in Example 1 3 o 4 The magnetocaloric effect curve of @PDA@ZIF-90 particles under the action of alternating magnetic field.
[0047] Fe prepared by embodiment 1 3 o 4 @PDA@ZIF-90 particles were dispersed in deionized water to a concentration of 10 mg / mL, and the magnetocaloric effect of the drug carrier was measured using a DM100 magnetocaloric effect analyzer (Spanish nanoscale biomagnetics company). When the magnetic field strength is set to 180Gauss, the magnetic field frequency is 409kHz, and the particle solution (10mg / mL) volume is 1mL, the alternating magnetic field acts for 10 minutes to make the solution temperature rise from 28°C to 46°C.
[0048] The result is as Figure 4 As shown, 1mL of particle solution (10mg / mL) is rapidly heated under the action of an alternating magnetic field (magnetic field strength 180Gauss, magnetic field frequency 409kHz), and can rise from 28°C to 46°C within 10 minutes. Illustrate the Fe prepa...
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