Multifunctional drug carrier, and preparation method and application thereof

A drug and carrier technology, applied in the field of materials science, can solve the problem of limited cancer effect and achieve good photothermal effect

Active Publication Date: 2018-12-28
HUANGGANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a multifunctional drug carrier with magnetothermal therapy and photothermal therapy functions and its preparation method and application, so as to solve the technical problem of the limited effect of drugs in the treatment of cancer in the prior art

Method used

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  • Multifunctional drug carrier, and preparation method and application thereof
  • Multifunctional drug carrier, and preparation method and application thereof
  • Multifunctional drug carrier, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] The drug carrier provided in this example comprises a metal organic framework ZIF-90 outer layer, a polydopamine middle layer and Fe 3 o 4 Granular core. The preparation method of the drug carrier comprises the following steps:

[0034] (1) 0.71g ferric chloride hexahydrate (FeCl 3 ·6H 2 O), 1.54g sodium citrate (C 6 h 5 Na 3 o 7 ), 0.63g urea (CH 4 N 2 O), 0.52g of polyacrylamide (PAM) was added to 70mL of deionized water and ultrasonically dissolved until it was completely dissolved to obtain a clear solution; then, the clear solution was transferred to a 100mL hydrothermal kettle, and after hydrothermal treatment at 180°C for 10 hours at room temperature Cooling; centrifuge at 8000rpm to collect the black precipitate, wash the black precipitate with deionized water, and dry it in vacuum at 60°C to obtain Fe 3 o 4 particles.

[0035] (2) 68mg Fe 3 o 4 Add the particles into 200mL of Tris buffer solution with pH=8.5, and disperse them evenly under ultraso...

Embodiment 2

[0040] Get the Fe that 30mg embodiment 1 prepares 3 o 4@PDA@ZIF-90 particles were dispersed in 12mL of doxorubicin (DOX) drug in PBS buffer solution (DOX concentration 0.5mg / mL), the above mixture was shaken at room temperature for 24 hours in a light-proof shaker, then centrifuged, PBS buffer Washed several times with liquid solution, and finally freeze-dried to obtain Fe loaded with DOX drug 3 o 4 @PDA @ZIF-90-DOX particles.

[0041] figure 2 For the Fe prepared in Example 1 and Example 2 3 o 4 , Fe 3 o 4 @PDA、Fe 3 o 4 @PDA @ZIF-90 and Fe 3 o 4 The thermogravimetric curve of @PDA@ZIF-90-DOX particles. The concentration of DOX drug on Fe was determined by thermogravimetric analysis. 3 o 4 The loading on @PDA@ZIF-90 particles is about 15%, which has a higher loading of anticancer drug DOX.

[0042] image 3 Fe prepared for Example 2 3 o 4 DOX release curves of @PDA@ZIF-90-DOX particles at pH 7.4, pH 6.0 and pH 4.5, and temperature 37°C.

[0043] The Fe that...

Embodiment 3

[0046] Figure 4 For the Fe prepared in Example 1 3 o 4 The magnetocaloric effect curve of @PDA@ZIF-90 particles under the action of alternating magnetic field.

[0047] Fe prepared by embodiment 1 3 o 4 @PDA@ZIF-90 particles were dispersed in deionized water to a concentration of 10 mg / mL, and the magnetocaloric effect of the drug carrier was measured using a DM100 magnetocaloric effect analyzer (Spanish nanoscale biomagnetics company). When the magnetic field strength is set to 180Gauss, the magnetic field frequency is 409kHz, and the particle solution (10mg / mL) volume is 1mL, the alternating magnetic field acts for 10 minutes to make the solution temperature rise from 28°C to 46°C.

[0048] The result is as Figure 4 As shown, 1mL of particle solution (10mg / mL) is rapidly heated under the action of an alternating magnetic field (magnetic field strength 180Gauss, magnetic field frequency 409kHz), and can rise from 28°C to 46°C within 10 minutes. Illustrate the Fe prepa...

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Abstract

The invention discloses a multifunctional drug carrier, and a preparation method and application thereof, and belongs to the field of materialogy. The multifunctional drug carrier has the functions ofmagnetic heat therapy and photo-thermal therapy, and comprises a metal organic frame ZIF-90 outer layer, a polydopamine interlayer and a Fe3O4 particle core. Superpara magnetism Fe3O4 particles are taken as a core, polydopamine coated Fe3O4 particles (Fe3O4@PDA) are formed through auto polymerization in a dopamine alkaline condition, and Zn<2+> is taken as metal ions to be assembled with organicligand imidazole-2-formaldehyde (ICA) to compound Fe3O4@PDA particles so as to prepare the multifunctional drug carrier Fe3O4@PDA@ZIF-90 particles. According to the multifunctional drug carrier disclosed by the invention, anti-cancer drugs can be loaded at high content, and the cancer therapy of drug chemotherapy with the functions of magnetic heat therapy and photo-thermal therapy can be realized.

Description

technical field [0001] The invention belongs to the field of materials science and relates to a drug carrier, specifically a multifunctional drug carrier with magnetothermal therapy and photothermal therapy functions, a preparation method and application thereof. Background technique [0002] The incidence of cancer is increasing year by year, and the mortality rate is high. Cancer has become the second largest mortality disease after cardiovascular and cerebrovascular diseases in developing countries. At present, the clinical cure rate of cancer is low, even if it is cured, the recurrence rate of cancer is extremely high, and it is easy to transfer. Therefore, cancer treatment has become an urgent problem in today's world. [0003] The current cancer treatment methods include surgery, radiation therapy, drug chemotherapy, gene therapy and hyperthermia. Although surgical treatment can remove most of the tumor tissue or inhibit the growth of tumor cells, it is relatively tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/34A61K47/02A61K47/22A61K31/704A61P35/00
CPCA61K9/5115A61K9/5123A61K9/5146A61K31/704A61K41/0052A61P35/00A61K2300/00
Inventor 朱钰方田正芳刘加星阮志军陈砚美
Owner HUANGGANG NORMAL UNIV
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