Multifunctional drug carrier, and preparation method and application thereof

A drug and carrier technology, applied in the field of materials science, can solve the problem of limited cancer effect and achieve good photothermal effect
CN109091674AActive Publication Date: 2018-12-28HUANGGANG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUANGGANG NORMAL UNIV
Publication Date
2018-12-28

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Abstract

The invention discloses a multifunctional drug carrier, and a preparation method and application thereof, and belongs to the field of materialogy. The multifunctional drug carrier has the functions ofmagnetic heat therapy and photo-thermal therapy, and comprises a metal organic frame ZIF-90 outer layer, a polydopamine interlayer and a Fe3O4 particle core. Superpara magnetism Fe3O4 particles are taken as a core, polydopamine coated Fe3O4 particles (Fe3O4@PDA) are formed through auto polymerization in a dopamine alkaline condition, and Zn<2+> is taken as metal ions to be assembled with organicligand imidazole-2-formaldehyde (ICA) to compound Fe3O4@PDA particles so as to prepare the multifunctional drug carrier Fe3O4@PDA@ZIF-90 particles. According to the multifunctional drug carrier disclosed by the invention, anti-cancer drugs can be loaded at high content, and the cancer therapy of drug chemotherapy with the functions of magnetic heat therapy and photo-thermal therapy can be realized.
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Description

technical field

[0001] The invention belongs to the field of materials science and relates to a drug carrier, specifically a multifunctional drug carrier with magnetothermal therapy and photothermal therapy functions, a preparation method and application thereof. Background technique

[0002] The incidence of cancer is increasing year by year, and the mortality rate is high. Cancer has become the second largest mortality disease after cardiovascular and cerebrovascular diseases in developing countries. At present, the clinical cure rate of cancer is low, even if it is cured, the recurrence rate of cancer is extremely high, and it is easy to transfer. Therefore, cancer treatment has become an urgent problem in today's world.

[0003] The current cancer treatment methods include surgery, radiation therapy, drug chemotherapy, gene therapy and hyperthermia. Although surgical treatment can remove most of the tumor tissue or inhibit the growth of tumor cells, it is relatively tr...

Claims

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