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A kind of medical compound coating agent, its preparation method and application

A coating agent and compound technology, applied in the field of medical compound coating agent, can solve the problems of difficult degradation and metabolism, large toxic and side effects of medical coatings, etc.

Active Publication Date: 2020-09-25
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the technical problem to be solved by the present invention is to provide a medical composite coating agent, its preparation method and application, which are used to solve the problems of large toxic and side effects and difficult degradation and metabolism of existing medical coatings, with higher safety

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  • A kind of medical compound coating agent, its preparation method and application
  • A kind of medical compound coating agent, its preparation method and application
  • A kind of medical compound coating agent, its preparation method and application

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preparation example Construction

[0035] The present invention also provides a method for preparing the above-mentioned medical composite coating agent, comprising the following steps:

[0036] The aqueous solution of bio-based ionic surfactant is mixed with the aqueous solution of bio-based ionic polymer, and reacted at 10-80° C. for 0.5-24 hours to obtain a medical composite coating agent.

[0037]The bio-based ionic surfactant is selected from triacetylcholic acid 2-hydroxyethyltrimethylammonium chloride, tributyrylcholic acid 2-hydroxyethyltrimethylammonium chloride, stearic acid 2- Hydroxyethyltrimethylammonium chloride, sodium N-deoxycholate-2-aminoethanesulfonate, sodium N-stearyl-2-sulfamate, and N-monocholesterylsuccinate-2- One of sodium taurine sulfonate.

[0038] The bio-based ionic surfactant can be self-made, or generally commercially available. In certain embodiments of the present invention, the bio-based ionic surfactant is commercially available sodium N-deoxycholic acid acyl-2-taurine (TCA...

Embodiment 1

[0110] Commercially available sodium N-deoxycholate-2-aminoethanesulfonate (TCA) was used as the biobased ionic surfactant. 6.00g TCA (0.0115mol anion) was dissolved in 100mL deionized water to obtain a TCA aqueous solution with a concentration of 6wt%, and 1.64g molecular weight was 15000~30000g / mol poly-L-lysine hydrochloride (PLS, 0.01 mol cation) was dissolved in 82mL of deionized water to obtain a PLS aqueous solution with a concentration of 2wt%. In a water bath at 80°C, the TCA aqueous solution was added dropwise to the PLS aqueous solution, fully stirred for 4h, and the time for adding was 30min. Afterwards, the white precipitate at the bottom was collected, fully washed 5 times with deionized water at 50° C., and dried in vacuum to obtain a PLS / TCA medical composite coating agent. The biological acid involved in the coating agent has 24 carbon atoms, and the solubility of the coating agent in ethanol and isopropanol is greater than 5%.

Embodiment 2

[0112] First prepare the bio-based ionic surfactant N-stearyl-2-sulfamate sodium (STA):

[0113] Dissolve 0.05mol 2-aminoethanesulfonic acid in tetrahydrofuran / water solution (the volume ratio of tetrahydrofuran and water is 80:20) to obtain a 5wt% 2-aminoethanesulfonic acid solution, and dissolve 0.025mol stearyl chloride in In tetrahydrofuran, a stearyl chloride solution with a concentration of 5 wt % was obtained. Add 0.05mol NaOH solid in the 2-aminoethanesulfonate sodium solution, after the NaOH solid dissolves, under room temperature, drop stearyl chloride solution, control the rate of addition, ensure that the dropwise addition is completed within 0.5h, and then continue After reacting for 12 hours, the solvent was removed and dried to prepare sodium N-stearyl-2-sulfamate (STA).

[0114] Dissolve 7.82g of sodium N-stearyl-2-sulfamate (STA, 0.02mol) in 100mL of deionized water to obtain an aqueous STA solution with a concentration of 7.82wt%, and dissolve 1.64g of PLS ​...

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Abstract

The invention relates to the technical field of anticoagulant and antibacterial coatings for medical devices, in particular to a medical composite coating agent, its preparation method and application. The medical composite coating agent provided by the invention consists of a bio-based ionic polymer It is prepared from the raw material of bio-based ionic surfactant; the bio-based ionic surfactant is selected from triacetylcholic acid 2-hydroxyethyl trimethylammonium chloride, tributyrylcholic acid 2-hydroxyethyl Trimethylammonium Chloride, 2-Hydroxyethyltrimethylammonium Stearate, Sodium N-Deoxycholic Acid-2-Suramic Acid, N-Stearyl-2-Sulphamic Acid One of sodium and sodium N-monocholesterol succinoyl-2-taurate. The specific bio-based ionic surfactant and the bio-based ionic polymer act synergistically, and the prepared medical composite coating has higher safety, and the medical coating has less toxic side effects and is easy to degrade and metabolize.

Description

technical field [0001] The invention relates to the technical field of anticoagulant and antibacterial coatings for medical devices, in particular to a medical composite coating agent, its preparation method and application. Background technique [0002] The use of interventional catheters is often accompanied by hospital-acquired infection and blood coagulation at the intervention site. According to reports, the proportion of infection in long-term indwelling urinary catheters can reach 50%, and the incidence of central venous catheter-related bloodstream infection increases at a rate of 0.44% per day, which significantly increases the survival risk and medical burden of patients. In most cases, germs enter the human body through the outer surface of the catheter at the wound site, and then adhere and multiply on the surface of the catheter, causing nosocomial infection. In addition, catheters, as guest materials, inevitably lead to coagulation when in contact with blood, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D177/00C09D105/08C09D105/10C09D7/63C08J7/04C08L75/04C08L23/06
CPCC08J7/0427C08J2323/06C08J2375/04C08J2405/08C08J2405/10C08J2477/00C09D7/63C09D105/08C09D105/10C09D177/00C08K5/42C08K5/19
Inventor 杨华伟栾世方陈家悦石恒冲殷敬华宋凌杰闫顺杰
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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