Preparation method of mitoxantrone supported nano-particle taking fluorinated graphene as carrier

A technology of fluorinated graphene and mitoxantrone, which is applied in the field of medicine, can solve the problems of limiting the application of fluorinated graphene, poor biocompatibility, cumbersome synthesis steps, etc., and achieve improved biocompatibility, convenient operation, and preparation The effect of simple process

Inactive Publication Date: 2019-01-04
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, poor biocompatibility due to its hydrophobicity, harsh preparation conditions and tedious synthesis steps severely limit the application of fluorinated graphene in the biological field.

Method used

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  • Preparation method of mitoxantrone supported nano-particle taking fluorinated graphene as carrier

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1) Cool the beaker to 0 °C in an ice-water bath, add a magnet, measure 20 mL of concentrated sulfuric acid with a graduated cylinder and add it to a 250 mL beaker; then weigh 0.5 flake graphite powder and 0.2 sodium nitrate into the beaker; then perform ultrasound , for 20 min;

[0038] 2) Place the beaker in step 1) in a magnetic stirring water bath, stir at 400 rpm for 20 min, keep the reaction temperature below 10 °C, then weigh 2 g of potassium permanganate on an electronic balance, within 25 min Slowly add in batches; this stage reacts for 1.5 h;

[0039] 3) Raise the temperature of the water bath in step 2) to 35 °C and react for 25 min;

[0040] 4) Measure 70mL of deionized water, cool it down to 0 ℃ in an ice-water bath, and slowly add it to the beaker in step 3); then adjust the temperature of the water bath in step 3) to about 90 ℃, and continue the reaction for 25 minutes with the assistance of stirring min;

[0041] 5) Add 50 mL of distilled water to the ...

Embodiment 2

[0051] 1) Cool the beaker to 0 °C in an ice-water bath, add a magnet, and add 23 mL of concentrated sulfuric acid to a 250 mL beaker with a graduated cylinder; then weigh 0.1 g flake graphite powder and 0.5 g sodium nitrate into the beaker; then Perform ultrasound for 5 minutes;

[0052] 2) Place the beaker in step 1) in a magnetic stirring water bath, stir at 600 rpm for 30 min, keep the reaction temperature below 10 °C, then weigh 3 g of potassium permanganate on an electronic balance, and weigh it at 28 Slowly add in batches within 1 min; react for 2 h at this stage;

[0053] 3) Raise the temperature of the water bath in step 2) to 38 °C and react for 30 min;

[0054] 4) Measure 100 mL of deionized water, cool it down to 0 ℃ in an ice water bath, and slowly add it to the beaker in step 3); then adjust the temperature of the water bath in step 3) to about 93 ℃, and continue the reaction with the assistance of stirring 27 minutes;

[0055] 5) Add 60 mL of distilled water t...

Embodiment 3

[0065] 1) Cool the beaker to 0 °C in an ice-water bath, add a magnet, measure 25 mL of concentrated sulfuric acid with a graduated cylinder and add it to a 250 mL beaker; then weigh 2 g flake graphite powder and 1 g sodium nitrate into the beaker; then Perform ultrasound for 30 min;

[0066] 2) Place the beaker in step 1) in a magnetic stirring water bath, stir at 800 rpm for 40 min, keep the reaction temperature below 10 °C, then weigh 4 g of potassium permanganate on an electronic balance, and weigh it at 30 Slowly add in batches within 1 min; react at this stage for 2.5 h;

[0067] 3) Raise the temperature of the water bath in step 2) to 40°C and react for 30 minutes;

[0068] 4) Measure 120 mL of deionized water, cool it down to 0 ℃ in an ice-water bath, and slowly add it to the beaker in step 3); then adjust the temperature of the water bath in step 3) to about 95 ℃, and continue the reaction with the assistance of stirring 30 minutes;

[0069] 5) Add 70 mL of distille...

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Abstract

The invention relates to the field of medicines, and discloses a preparation method of a mitoxantrone supported nano-particle taking fluorinated graphene as a carrier. The method includes the steps: taking flake graphite as a raw material to prepare graphene oxide; fluorinating the graphene oxide by diethylaminosulphur trifluoride; converting parts of oxygen-containing groups into fluorine-containing groups to prepare part of fluorinated graphene; dispersing the part of fluorinated graphene into phosphate buffering solution with pH (potential of hydrogen) of 7.4 to obtain part of fluorinated graphene solution; performing reaction on the part of fluorinated graphene solution and the mitoxantrone to obtain the nano-particle. The surface of the part of fluorinated graphene has a lot of oxygen-containing hydrophilic functional groups, medicines are loaded by hydrogen bonds, and biocompatibility is improved. According to the nano-particle prepared by the method, cells cannot be remarkably affected in later experiment process, scientificity of experimental results cannot be affected, experimental processes are simple and convenient to operate, and harsh reaction conditions and special reaction devices are omitted.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for preparing nanoparticles loaded with mitoxantrone by using fluorinated graphene as a carrier. Background technique [0002] Fluorinated graphene has been widely concerned as a new derivative of graphene since it was successfully prepared by the Geim research group for the first time in 2010. It is similar to it and still has good mechanical properties. At the same time, it introduces fluorine Atoms, thus obtaining many unique and excellent properties. It has excellent electronic, optical and mechanical properties, as well as the effect of reducing interfacial energy, as well as good thermal stability and oxidation resistance. This makes the main research hotspots of fluorinated graphene in the fields of optics, electronics and theoretical calculation. [0003] Fluorinated graphene not only inherits the excellent properties of graphene materials, but also has significant ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/52A61K31/136A61P35/00C01B32/198C01B32/194
CPCA61K9/1611A61K31/136A61P35/00C01B32/194C01B32/198C01P2002/82
Inventor 王秉金小康黄芊蔚胡锦华陈碧玲
Owner ZHEJIANG SCI-TECH UNIV
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