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A green and controllable synthesis method of gold nanoparticles and its one-step peptide functionalization method

A synthesis method and nano-gold technology, applied in the field of nano-materials, can solve problems such as hindering experimental research, difficulty in predicting and accurately controlling the particle size of nano-gold, harming the human body and the environment, and achieving environmental friendliness, good ionic strength stability and The effect of pH stability and simple steps

Active Publication Date: 2022-02-08
LINGNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the synthesis and preparation of nano-gold has entered a relatively mature stage. Although individual methods can change the particle size of nano-gold to a certain extent by changing the ratio of materials in the reaction, it is difficult for these methods to predict and predict the particle size of nano-gold. Precise control, thus hampering further experimental studies
In addition, most of the existing synthetic methods require high-temperature reactions, while a few room-temperature preparation methods require the use of hydroxylamine hydrochloride (NH 2 OH·HCl), sodium borohydride (NaBH 4 ) and other dangerous reagents, causing great harm to the human body and the environment

Method used

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  • A green and controllable synthesis method of gold nanoparticles and its one-step peptide functionalization method
  • A green and controllable synthesis method of gold nanoparticles and its one-step peptide functionalization method
  • A green and controllable synthesis method of gold nanoparticles and its one-step peptide functionalization method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1 Nano gold synthesis

[0069] Nano gold is synthesized, and its steps are as follows:

[0070] (1) It is 0.5 mg / mL to configure the concentration of tyrosine with a sodium hydroxide solution (pH value of 12.7) of 0.05 mol / L, and dilute chloroauric acid with ultrapure water to be 2.94 mmol / L;

[0071] (2) Mix 1 mL of tyrosine and 0.5 mL of chloroauric acid (the volume ratio of tyrosine to chloroauric acid is 2:1), and react at 37° C. for 120 minutes to obtain gold nanoparticles.

[0072] The synthesis step is simple and easy, the required equipment and reagents are easily obtained, the energy consumption is low, the method is environmentally friendly, and conforms to the concept of sustainable development.

Embodiment 2

[0073] Embodiment 2 nanometer gold is synthesized

[0074] Nano gold is synthesized, and its steps are as follows:

[0075] (1) It is 0.5 mg / mL to configure the concentration of tyrosine with a sodium hydroxide solution (pH value of 12.7) of 0.05 mol / L, and dilute chloroauric acid with ultrapure water to be 2.94 mmol / L;

[0076] (2) Mix 0.6 mL of tyrosine and 1 mL of chloroauric acid (the volume ratio of tyrosine to chloroauric acid is 0.6:1), and react at 37° C. for 120 minutes to obtain gold nanoparticles.

Embodiment 3

[0077] Embodiment 3 nanometer gold is synthesized

[0078] Nano gold is synthesized, and its steps are as follows:

[0079] (1) It is 0.5 mg / mL to configure the concentration of tyrosine with a sodium hydroxide solution (pH value of 12.7) of 0.05 mol / L, and dilute chloroauric acid with ultrapure water to be 2.94 mmol / L;

[0080] (2) Mix 1.5 mL of tyrosine and 0.5 mL of chloroauric acid (the volume ratio of tyrosine to chloroauric acid is 3:1), and react at 37° C. for 120 minutes to obtain gold nanoparticles.

[0081] Experiments have found that when the volume ratio of tyrosine to chloroauric acid is 0.6 to 3:1, nano-gold can be prepared under experimental conditions, and the effect is better; among them, when the volume ratio of tyrosine to chloroauric acid When the ratio is 2:1, the reproducibility of nano gold synthesis is good and the yield is high; while if the volume ratio of tyrosine to chloroauric acid is low, the reproducibility of the experimental effect will be poo...

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Abstract

The invention discloses a green controllable synthesis method of nano gold and a one-step peptide functionalization method thereof. The method comprises the following steps: first, use an alkaline buffer solution with a pH value of 8.0 to 12.7 to prepare a tyrosine solution with a concentration of 0.15 to 0.5 mg / mL; then mix the tyrosine solution and the chloroauric acid solution; By reacting at ~41°C for 0.5-14 h, nano-gold with controllable particle size can be obtained. The green controllable synthesis method of nano-gold of the present invention is simple in operation and mild in conditions, and it is convenient to couple the preparation process of nano-gold with the biological functionalization process, and the particle size of nano-gold shows a good linear relationship with the pH value, and the particle size can be precisely controlled. High practicability; the preparation method of functionalized gold nanoparticles of the present invention can be functionalized in one step on the basis of synthesizing gold nanoparticles, saving time; and the functionalized gold nanoparticles prepared by the present invention are better coated and have good ionic strength stability and pH stability.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials. More specifically, it relates to a green and controllable synthesis method of nano gold and its one-step peptide functionalization method. Background technique [0002] In recent years, noble metal nanomaterials have been developed rapidly. Among them, gold nanoparticles are widely used in optical sensing, electrochemical sensing, biological analysis, chemical analysis, self-assembly and nano-devices. In various research fields, there are special requirements for the particle size of gold nanoparticles. Therefore, finding a preparation method of nano-gold with controllable particle size is of great significance to promote the application of nano-gold. [0003] Currently, the methods used to prepare gold particles include physical and chemical methods. The physical method is mainly to directly convert gold into nanoparticles through various dispersion techniques, mainly including v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B82Y40/00B22F1/054B22F1/102G01N33/68
CPCG01N33/68B82Y40/00B22F9/24B22F1/102
Inventor 周国华闫小宁
Owner LINGNAN NORMAL UNIV
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