A bioceramic slurry for photocuring 3D printing and its preparation method, bone tissue engineering scaffold and its application
A bioceramic and 3D printing technology, applied in the field of ceramic materials, achieves fine and controllable pore structure, good fluidity, and promotes bone regeneration
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
preparation example Construction
[0030] The present invention also provides a method for preparing bioceramic slurry described in the above technical solution, comprising the following steps:
[0031] Mixing lithium-made stone nanopowder and β-tricalcium phosphate powder by wet ball milling for 12 to 36 hours and then drying to obtain a solid phase;
[0032] Mix the photosensitive resin, photoinitiator and dispersant with magnetic force, mechanical force or microwave for 10-60 minutes to obtain a liquid phase;
[0033] The solid phase is added to the liquid phase, and mixed by magnetic force, mechanical force or microwave for 10-60 minutes to obtain a bioceramic slurry.
[0034] In the invention, the lithium-made stone nanometer powder and the beta-tricalcium phosphate powder are mixed and then dried to obtain a solid phase.
[0035] In the present invention, the mixing medium of the lithium-made stone nanopowder and β-tricalcium phosphate powder is preferably dehydrated alcohol; the mixing method is prefera...
Embodiment 1
[0046] According to the weight content, wet ball milling of 5% lithium-made stone nanopowder and 53% β-tricalcium phosphate powder in absolute ethanol for 18 hours, and drying at 60° C. for 24 hours to obtain a solid phase;
[0047] 40% photosensitive resin, 1% photoinitiator and 1% dispersant were magnetically stirred for 20 minutes to obtain a liquid phase;
[0048] Adding the solid phase to the liquid phase, stirring mechanically for 40 minutes, to obtain a bioceramic slurry;
[0049] The obtained bioceramic slurry was prepared by photocuring 3D printing, high-temperature degreasing and high-temperature sintering to obtain bone tissue engineering scaffolds. Light-curing 3D printing conditions: the light source is ultraviolet light, the wavelength is 400nm, the thickness of the light-curing layer is 50μm, and the exposure intensity is 100mJ / cm 2 , exposure time 2s; high temperature degreasing conditions: degreasing temperature 500°C, heating rate 5°C / min, degreasing time 30...
Embodiment 2
[0052] According to the method of Example 1, bioceramic slurry and bone tissue engineering scaffold were prepared. The content by weight of the bioceramic slurry is: 0.1% lithium-made stone nano powder, 58% β-tricalcium phosphate powder, 40% photosensitive resin, 1% photoinitiator and 0.9% dispersant.
[0053] Light-curing 3D printing conditions: the light source is ultraviolet light, the wavelength is 400nm, the thickness of the light-curing layer is 50μm, and the exposure intensity is 100mJ / cm 2 , exposure time 2s; high temperature degreasing conditions: degreasing temperature 500°C, heating rate 5°C / min, degreasing time 30h, cooling with the furnace; high temperature sintering conditions: sintering temperature 1250°C, heating rate 10°C / min, sintering After 3 hours of cooling in the furnace, the bone tissue engineering scaffold was prepared.
[0054] After testing, the prepared bioceramic bone tissue engineering scaffold has a compressive strength of 22 MPa; a porosity of 8...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle diameter | aaaaa | aaaaa |
| particle diameter | aaaaa | aaaaa |
| particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More