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Preparation method of fluoroquinolone antibiotic adsorbent

A technology of fluoroquinolones and quinolones, which is applied in the field of preparation of cobalt sulfate-UIO materials to remove fluoroquinolone antibiotics adsorbents, achieving the effects of large adsorption capacity, uniform particle size, and high adsorption efficiency

Inactive Publication Date: 2019-01-18
HENAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in practical applications, the removal efficiency of UIO series framework materials for fluoroquinolone antibiotics can only reach about 50%.

Method used

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  • Preparation method of fluoroquinolone antibiotic adsorbent
  • Preparation method of fluoroquinolone antibiotic adsorbent
  • Preparation method of fluoroquinolone antibiotic adsorbent

Examples

Experimental program
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Embodiment 1

[0022] A preparation method of fluoroquinolone antibiotic adsorbent, comprising the following steps:

[0023] 1), according to the molar ratio of 1:1, zirconium tetrachloride and terephthalic acid were dissolved in 40mL of N,N-dimethylformamide to obtain A solution;

[0024] 2) Transfer solution A into a hydrothermal reactor, react at 120°C for 24 hours, cool to room temperature, centrifuge, wash, and dry at 80°C for 24 hours to obtain an intermediate product;

[0025] 3) Dissolve the intermediate product and cobalt sulfate in methanol at a mass ratio of 1:0.5 to obtain solution B, and magnetically stir solution B at 40°C for 1 hour;

[0026] 4) Cool to room temperature, centrifuge, and dry at 80°C for 24 hours to obtain the fluoroquinolone antibiotic adsorbent.

Embodiment 2

[0028] A preparation method of fluoroquinolone antibiotic adsorbent, comprising the following steps:

[0029] 1), according to the molar ratio of 1:2, zirconium tetrachloride and terephthalic acid were dissolved in 40mL of N,N-dimethylformamide to obtain A solution;

[0030] 2) Transfer solution A into a hydrothermal reactor, react at 120°C for 24 hours, cool to room temperature, centrifuge, wash, and dry at 80°C for 24 hours to obtain an intermediate product;

[0031] 3) Dissolve the intermediate product and cobalt sulfate in methanol at a mass ratio of 1:1 to obtain solution B, and magnetically stir solution B at 40°C for 1 hour;

[0032] 4) Cool to room temperature, centrifuge, and dry at 80°C for 24 hours to obtain the fluoroquinolone antibiotic adsorbent.

Embodiment 3

[0034] A preparation method of fluoroquinolone antibiotic adsorbent, comprising the following steps:

[0035] 1), according to the molar ratio of 1:3, zirconium tetrachloride and terephthalic acid were dissolved in 40mL of N,N-dimethylformamide to obtain A solution;

[0036] 2) Transfer solution A into a hydrothermal reactor, react at 120°C for 24 hours, cool to room temperature, centrifuge, wash, and dry at 80°C for 24 hours to obtain an intermediate product;

[0037] 3) Dissolve the intermediate product and cobalt sulfate in ethanol at a mass ratio of 1:0.8 to obtain solution B, and magnetically stir solution B at 25°C for 1 hour;

[0038] 4) Cool to room temperature, centrifuge, and dry at 60°C for 24 hours to obtain the fluoroquinolone antibiotic adsorbent.

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Abstract

The invention discloses a preparation method of a fluoroquinolone antibiotic adsorbent. The preparation method comprises the following steps: 1) dissolving metal salt and an organic ligand in N,N-dimethylformamide to obtain a solution A; 2) transferring the solution A into a hydrothermal reaction kettle, and reacting for 20-30h at 100-160 DEG C; cooling to room temperature; performing centrifugation, washing and drying to obtain an intermediate product; 3) dissolving the intermediate product and cobalt sulfate in an organic solvent, performing magnetic stirring and cooling to room temperature;performing centrifugation and drying to obtain the quinolone antibiotic adsorbent. The pore diameter of the adsorbent is 1.5-3.2nm, and the specific surface area is 698-1,143m<2> / g. The preparation method disclosed by the invention has the advantages of simple preparation steps, low cost, high removal efficiency of quinolone antibiotic pollutants and broad application prospect.

Description

technical field [0001] The invention relates to the application of metal-organic framework (MOF) materials, in particular to the technical field of preparation of a cobalt sulfate-UIO material for removing fluoroquinolone antibiotic adsorbents. Background technique [0002] Fluoroquinolone antibiotics are a kind of synthetic antibacterial drugs, which are widely used in clinic because of their good antibacterial effect, strong effect and easy absorption. As a common drug, fluoroquinolone antibiotics cannot be completely absorbed once ingested by humans or animals, and most of the remaining part enters the environment through human waste in the form of protozoa, causing pollution. Due to the long-term irrational use of such drugs, it will remain and accumulate in the environment, thereby endangering ecological health. Therefore, the adsorption and removal of fluoroquinolone pollutants will inevitably become a new trend. [0003] Metal-organic framework materials are a new t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/22B01J20/28B01J20/30C02F1/28C02F101/38C02F101/36C02F101/34
CPCB01J20/226B01J20/28011B01J20/28016B01J20/3085C02F1/285C02F2101/34C02F2101/36C02F2101/38
Inventor 朱桂芬陈乐田王醒程国浩逯通李宛宛王利芳苏现伐茹祥莉樊静
Owner HENAN NORMAL UNIV
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