Method of preparing 3-isopropyl-5-cresol and carvacrol with 3-carene

A technology of isopropyl and carvacrol, applied in chemical instruments and methods, preparation of carbon-based compounds, preparation of organic compounds, etc., can solve the problems of low selectivity of single products, difficult to separate, etc., and achieves the realization of reusable, High utilization rate of raw materials and easy recovery
CN109232193AActive Publication Date: 2019-01-18INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
Publication Date
2019-01-18

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Abstract

The invention discloses a method of preparing 3-isopropyl-5-cresol and carvacrol with 3-carene. The method comprises the following steps that 3-carene is reacted with oxygen at a room temperature to produce a product I under the catalysis of CrO3-Al2O3, wherein the product I is prepared from the main components including 5-carone, 2-carone and 4-carone with the selectivity ratio being about 10.8 to 3.5 to 1.0; the product I is distilled to recover 3-carene, wherein the recovery rate is larger than 80 percent, and the recovery purity is larger than 94 percent; the residual components are converted to a product II at 230 DEG C under catalysis of a 13X type molecular sieve, and reduced pressure distillation is performed on the product II to obtain a mixed phenol product with the purity largerthan 96 percent, wherein the product II is prepared from the main components including 3-isopropyl-5-cresol and carvacrol, the raw material conversion rate is 100 percent, the total selectivity of phenolic products can reach 98 percent, and the selectivity ratio of the two phenolic products is about 2.2 to 1.0; and column chromatography isolation is performed on the product II to obtain 3-isopropyl-5-cresol and carvacrol with the purities larger than 97 percent respectively.
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Description

technical field

[0001] The invention relates to a method for preparing 3-isopropyl-5-cresol and carvacrol from 3-carene, in particular to a method for preparing 3-isopropyl-5-cresol and carvacrol through oxidation and isomerization of 3-carene respectively. - Cresol and carvacrol method. Background technique

[0002] 3-isopropyl-5-cresol, also known as 5-isopropyl-3-cresol, 5-thymol, m-thymol, etc., is isomers with thymol and carvacrol, and has Special aroma similar to thymol. 3-isopropyl-5-cresol itself has biological activities such as anti-corrosion, anti-oxidation, antibacterial and insecticidal, and is also a key precursor for the synthesis of other active substances, such as carbamate derivatives of alkyl-substituted cresols It is an important class of pesticides, and due to the meta-substitution activity > ortho > para, secondary alkyl activity > tertiary alkyl > n-alkyl, 4-carbon chain > 3-carbon chain or 5-carbon chain > other carbon chains , so...

Claims

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